Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Louis-Alexandre Fournier"'
Autor:
Emily Yun-Chia Chang, Shuhe Tsai, Maria J. Aristizabal, James P. Wells, Yan Coulombe, Franciele F. Busatto, Yujia A. Chan, Arun Kumar, Yi Dan Zhu, Alan Ying-Hsu Wang, Louis-Alexandre Fournier, Philip Hieter, Michael S. Kobor, Jean-Yves Masson, Peter C. Stirling
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Accumulations of R-loops can lead to genome instability. Here the authors reveal a role for the MRN complex in suppressing R-loops and associated DNA damage at transcription–replication conflicts.
Externí odkaz:
https://doaj.org/article/a6da048a2a604ec29f09e5727eff77ce
Autor:
Shuhe Tsai, Louis-Alexandre Fournier, Emily Yun-Chia Chang, James P Wells, Sean W Minaker, Yi Dan Zhu, Alan Ying-Hsu Wang, Yemin Wang, David G Huntsman, Peter C Stirling
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009238 (2021)
ARID1A is a core DNA-binding subunit of the BAF chromatin remodeling complex, and is lost in up to 7% of all cancers. The frequency of ARID1A loss increases in certain cancer types, such as clear cell ovarian carcinoma where ARID1A protein is lost in
Externí odkaz:
https://doaj.org/article/330f9ddec6dc43c09ea6f032eae0dc87
Publikováno v:
G3 Genes|Genomes|Genetics. 12
In the past decade, there has been a growing appreciation for R-loop structures as important regulators of the epigenome, telomere maintenance, DNA repair, and replication. Given these numerous functions, dozens, or potentially hundreds, of proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23eb3507cd36d40cecacef084b1fd2f4
https://doi.org/10.1093/g3journal/jkac142
https://doi.org/10.1093/g3journal/jkac142
Autor:
David G. Huntsman, Yemin Wang, Alan Ying-Hsu Wang, Peter C. Stirling, James P. Wells, Yi Dan Zhu, Emily Yun-Chia Chang, Sean W. Minaker, Shuhe Tsai, Louis-Alexandre Fournier
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 4, p e1009238 (2021)
PLoS Genetics, Vol 17, Iss 4, p e1009238 (2021)
ARID1A is a core DNA-binding subunit of the BAF chromatin remodeling complex, and is lost in up to 7% of all cancers. The frequency of ARID1A loss increases in certain cancer types, such as clear cell ovarian carcinoma where ARID1A protein is lost in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80302d90787bea7c6821ea9e572c10b5
http://europepmc.org/articles/PMC8055027
http://europepmc.org/articles/PMC8055027
Autor:
Edmund Su, Theodore Smith, Peter C. Stirling, Arun Kumar, Martin Hirst, Louis-Alexandre Fournier, Michelle Moksa
Publikováno v:
SSRN Electronic Journal.
In the past decade there has been a growing appreciation for R-loop structures as important regulators of the epigenome, telomere maintenance, DNA repair and replication. Given these numerous functions, dozens, or potentially hundreds, of proteins co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5297e01793b12b4220f51117744eb2
https://doi.org/10.2139/ssrn.3931637
https://doi.org/10.2139/ssrn.3931637
Autor:
Arun Kumar, Yan Coulombe, Maria J. Aristizabal, Jean-Yves Masson, Shuhe Tsai, Yi Dan Zhu, Peter C. Stirling, Louis-Alexandre Fournier, Emily Yun-Chia Chang, Philip Hieter, Yujia Alina Chan, Michael S. Kobor, Franciele F. Busatto, Alan Ying-Hsu Wang, James P. Wells
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Ectopic R-loop accumulation causes DNA replication stress and genome instability. To avoid these outcomes, cells possess a range of anti-R-loop mechanisms, including RNaseH that degrades the RNA moiety in R-loops. To comprehensively identify anti-R-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345515403689908d285f14a420445d7d
https://doi.org/10.1038/s41467-019-12271-w
https://doi.org/10.1038/s41467-019-12271-w
Autor:
Philip Hieter, Yi Dan Zhu, Yujia Alina Chan, Jean-Yves Masson, James P. Wells, Peter C. Stirling, Shu-Huei Tsai, Emily Yun-Chia Chang, Louis-Alexandre Fournier, Yan Coulombe
SUMMARYEctopic R-loop accumulation causes DNA replication stress and genome instability. To avoid these outcomes, cells possess a range of anti-R-loop mechanisms, including RNaseH that degrades the RNA moiety in R-loops. To comprehensively identify a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a9e28e5f7f4fdc361c9cc9dc9e4521
Publikováno v:
Genes
Genes, Vol 9, Iss 12, p 622 (2018)
Genes, Vol 9, Iss 12, p 622 (2018)
Eukaryotic DNA replication occurs in the context of chromatin. Recent years have seen major advances in our understanding of histone supply, histone recycling and nascent histone incorporation during replication. Furthermore, much is now known about
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021f0987710959d79708f67844f23bca
https://pubmed.ncbi.nlm.nih.gov/30544989
https://pubmed.ncbi.nlm.nih.gov/30544989