Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Louis Y. P. Luk"'
Publikováno v:
ACS Bio & Med Chem Au, Vol 4, Iss 1, Pp 68-76 (2023)
Externí odkaz:
https://doaj.org/article/e5e53445b0674d59aeffdd1c31d5f6f9
Autor:
Alexander J. Lander, Laura Domínguez Mercado, Xuefei Li, Irshad Maajid Taily, Brandon L. Findlay, Yi Jin, Louis Y. P. Luk
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-7 (2023)
Abstract Tryptophan is frequently found on the surface of membrane-associated proteins that interact with the lipid membrane. However, because of their multifaceted interactions, it is difficult to pinpoint the structure-activity relationship of each
Externí odkaz:
https://doaj.org/article/6d0f8cfe77604de78e87727469801653
Autor:
Heather C. Hayes, Louis Y. P. Luk
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Agitation is a commonly encountered stress for enzymes during all stages of production and application, but investigations that aim to improve their tolerance using topological engineering have yet to be reported. Here, the plastic-degrading
Externí odkaz:
https://doaj.org/article/447f669f62184947a3b7dbb3723fdf77
Publikováno v:
Biomolecules, Vol 12, Iss 5, p 725 (2022)
Despite continuous advances, anticancer therapy still faces several technical hurdles, such as selectivity on cellular and subcellular targets of therapeutics. Toward addressing these limitations, we have combined the use of proapoptotic peptides, tr
Externí odkaz:
https://doaj.org/article/45f54fc5eb294ea8949ac11ff8bf3a6f
Autor:
Shu-Jung Lai, I-Fan Tu, Wan-Ling Wu, Jhih-Tian Yang, Louis Y. P. Luk, Mei-Chin Lai, Yu-Hsuan Tsai, Shih-Hsiung Wu
Publikováno v:
BMC Microbiology, Vol 17, Iss 1, Pp 1-10 (2017)
Abstract Background Phosphorylation of amino acid residues on proteins is an important and common post-translational modification in both eukaryotes and prokaryotes. Most research work has been focused on phosphorylation of serine, threonine or tyros
Externí odkaz:
https://doaj.org/article/de6916a616f64711a82baa0b91c9172e
Publikováno v:
Molecules, Vol 25, Iss 10, p 2457 (2020)
In this report, the streptavidin-biotin technology was applied to enable organocatalytic aldol addition. By attaching pyrrolidine to the valeric motif of biotin and introducing it to streptavidin (Sav), a protein-based organocatalytic system was crea
Externí odkaz:
https://doaj.org/article/e8fd71f06ee84763b6be624edde1b410
Publikováno v:
Wellcome Open Research, Vol 3 (2018)
Background: Identification of organocatalysts functioning in aqueous environments will provide methods for more sustainable chemical transformations and allow tandem reactions with biocatalysts, like enzymes. Here we examine three water-soluble carba
Externí odkaz:
https://doaj.org/article/4ad8eb4ccde54bf0810f055b9cad5685
Autor:
Jiahn-Haur Liao, Cheng-Han Tsai, Sanjay G. Patel, Jhih-Tian Yang, I-Fan Tu, Matteo Lo Cicero, Magdalena Lipka-Lloyd, Wan-Ling Wu, Wen-Jie Shen, Meng-Ru Ho, Chi-Chi Chou, Garima R. Sharma, Hiroki Okanishi, Louis Y. P. Luk, Yu-Hsuan Tsai, Shih-Hsiung Wu
Publikováno v:
Frontiers in Molecular Biosciences, Vol 4 (2017)
Lysine acetylation is a prevalent post-translational modification in both eukaryotes and prokaryotes. Whereas this modification is known to play pivotal roles in eukaryotes, the function and extent of this modification in prokaryotic cells remain lar
Externí odkaz:
https://doaj.org/article/c599542e17e942acba43c254224341a9
Autor:
Miquel À. Galmés, Alexander R. Nödling, Kaining He, Louis Y. P. Luk, Katarzyna Świderek, Vicent Moliner
Publikováno v:
Repositori Universitat Jaume I
Universitat Jaume I
Universitat Jaume I
While there has been emerging interest in designing new enzymes to solve practical challenges, computer-based options to redesign catalytically active proteins are rather limited. Here, a rational QM/MM molecular dynamics strategy based on combining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d717b21af7e55c8cca313d4af299760
https://doi.org/10.1039/d2sc00778a
https://doi.org/10.1039/d2sc00778a
Autor:
Raquel Cruz‐Samperio, Robert J. Mart, Louis Y. P. Luk, Yu‐Hsuan Tsai, Arwyn T. Jones, Rudolf K. Allemann
Publikováno v:
ChemBioChem. 23
Protein therapeutics offer exquisite selectivity in targeting cellular processes and behaviors, but are rarely used against non-cell surface targets due to their poor cellular uptake. While cell-penetrating peptides can be used to deliver recombinant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ea382c7860d3e648fd2e2614ac6562
https://doi.org/10.1002/cbic.202200115
https://doi.org/10.1002/cbic.202200115