Výsledky vyhledávání - "Louis St L, O'Dea"

Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk

Autor: Jean-Claude Tardif, Ewa Karwatowska-Prokopczuk, Eric St Amour, Christie M Ballantyne, Michael D Shapiro, Patrick M Moriarty, Seth J Baum, Eunju Hurh, Victoria J Bartlett, Joyce Kingsbury, Amparo L Figueroa, Veronica J Alexander, Joseph Tami, Joseph L Witztum, Richard S Geary, Louis St L O’Dea, Sotirios Tsimikas, Daniel Gaudet

Publikováno v: European heart journal, vol 43, iss 14

Aims Hypertriglyceridaemia is associated with increased risk of cardiovascular events. This clinical trial evaluated olezarsen, an N-acetyl-galactosamine-conjugated antisense oligonucleotide targeted to hepatic APOC3 mRNA to inhibit apolipoprotein C-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab435f70ddb9874ac3d5d38b0c089f7
https://escholarship.org/uc/item/52k3p81s

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T-SPOT.TB Interferon-γ Release Assay Performance in Healthcare Worker Screening at Nineteen U.S. Hospitals

Autor: Chris P. Kadlecek, Kathy Murray, Philip Adamo, Pamela Drewry, Albert F. Rielly, John Balser, Peter Wrighton-Smith, Janet Matsubara, Thomas C. King, Mark Upfal, Marcie DeWitt, Andrew Gottlieb, Frances Humphrey-Carothers, Edward J Bernacki, Jeffrey G. Jones, Louis St. L. O'Dea

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 192:367-373

Rationale: Interferon-γ release assays have significant advantages over tuberculin skin testing in many clinical situations. However, recent studies have called into question their reliability in serial testing of healthcare workers because of repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c9108186ff211bf8c7e3e8cee6835b7
https://doi.org/10.1164/rccm.201501-0199oc

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Effects of Abaloparatide, a Human Parathyroid Hormone-Related Peptide Analog, on Bone Mineral Density in Postmenopausal Women with Osteoporosis

Autor: Jose R. Zanchetta, Louis St. L. O’Dea, C. Richard Lyttle, Kathleen Banks, Benjamin Z. Leder, Gary Hattersley, Prasana Kumar, Kathleen McKay

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 100:697-706

Abaloparatide is a novel synthetic peptide analog of parathyroid hormone-related protein (PTHrP) that is currently being developed as a potential anabolic agent in the treatment of postmenopausal osteoporosis.This study sought to assess the effects o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158dabbf360a372220cdd1d96f8d9c6c
https://doi.org/10.1210/jc.2014-3718

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Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140

Autor: John A. Katzenellenbogen, Matthew S. Burge, C. Richard Lyttle, Kyla Gallacher, Jennifer L. Green, Gary Hattersley, Maysoun Shomali, Alexei Tchesnokov, Dottie Paquin, Louis St. L. O’Dea, Dennis R. Compton, Hillary Herendeen, Bishwabhusan Sahoo, Chris P. Miller, Sean Kerrigan, Michael Nickels

Publikováno v: ACS Medicinal Chemistry Letters. 2:124-129

This report describes the discovery of RAD140, a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). The characterization of RAD140 in several preclinical models of anabolic androgen action is also described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49883bca23cc766e3a9dc26159dd75b
https://doi.org/10.1021/ml1002508

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Sex Steroid Control of Gonadotropin Secretion in the Human Male. I. Effects of Testosterone Administration in Normal and Gonadotropin-Releasing Hormone-Deficient Men*

Autor: David A. Schoenfeld, Joel S. Finkelstein, William F. Crowley, Louis St. L. O’Dea, Christopher Longcope, Randall W. Whitcomb

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 73:609-620

The precise sites of action of the negative feed-back effects of gonadal steroids in men remain unclear. To determine whether testosterone (T) administration can suppress gonadotropin secretion directly at the level of the pituitary, the pituitary re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e5a5861099b189799850b9d99065e4
https://doi.org/10.1210/jcem-73-3-609

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Follicular development induced by recombinant luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in anovulatory women with LH and FSH deficiency: evidence of a threshold effect

Autor: Fanny O’Brien, Karen Currie, G. Hemsey, Louis St. L. O’Dea

Publikováno v: Current medical research and opinion. 24(10)

To assess the requirement for luteinizing hormone (LH) in women deficient in LH and follicle-stimulating hormone (FSH).A prospective, randomized, parallel-group, multicentre study was carried out in tertiary care and academic medical centres. Women w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea435b0e4d69351baec7694c66cf80fb
https://pubmed.ncbi.nlm.nih.gov/18727841

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Stimulation of spermatogenesis with recombinant human follicle-stimulating hormone (follitropin alfa; GONAL-f): long-term treatment in azoospermic men with hypogonadotropic hypogonadism

Autor: Thomas Weber, J Brentzel, Alvin M. Matsumoto, Peter J. Snyder, Louis St. L. O’Dea, Kathryn A. Martin, Shalender Bhasin, Stephen J. Winters, Daniel I. Spratt

Publikováno v: Fertility and sterility. 92(3)

Objective To demonstrate the efficacy and safety of follitropin alfa administered with hCG on spermatogenesis in adult male hypogonadotropic hypogonadism (HH) patients. Design Phase III, multicenter, open-label, noncomparative. Setting Seven US medic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4f4f3324088da0f935105f2ca2e50d
https://pubmed.ncbi.nlm.nih.gov/18930190

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Utility of Freeα-Subunit as an Alternative Neuroendocrine Marker of Gonadotropin-Releasing Hormone (GnRH) Stimulation of the Gonadotroph in the Human: Evidence from Normal and GnRH-Deficient Men*

Autor: Louis St. L. O’Dea, Randall W. Whitcomb, William F. Crowley, Denise M. Heavern, Joel S. Finkelstein

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 70:1654-1661

To examine the hypothesis that the secretion of free alpha-subunit (FAS) can serve as an alternative to LH as a neuroendocrine marker of gonadotroph stimulation by GnRH in euthyroid humans, we have investigated the relationship of pulsatile FAS secre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f520536611b49519fe215d14238b67
https://doi.org/10.1210/jcem-70-6-1654

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