Identification of growth hormone receptor as a relevant target for precision medicine in low‐EGFR expressing glioblastoma

Autor: Maïté Verreault, Irma Segoviano Vilchis, Shai Rosenberg, Nolwenn Lemaire, Charlotte Schmitt, Jérémy Guehennec, Louis Royer‐Perron, Jean‐Léon Thomas, TuKiet T. Lam, Florent Dingli, Damarys Loew, François Ducray, Sophie Paris, Catherine Carpentier, Yannick Marie, Florence Laigle‐Donadey, Audrey Rousseau, Natascha Pigat, Florence Boutillon, Franck Bielle, Karima Mokhtari, Stuart J. Frank, Aurélien deReyniès, Khê Hoang‐Xuan, Marc Sanson, Vincent Goffin, Ahmed Idbaih

Publikováno v: Clinical and Translational Medicine, Vol 12, Iss 7, Pp n/a-n/a (2022)

Abstract Objective New therapeutic approaches are needed to improve the prognosis of glioblastoma (GBM) patients. Methods With the objective of identifying alternative oncogenic mechanisms to abnormally activated epidermal growth factor receptor (EGF

Externí odkaz: https://doaj.org/article/eda0001ce8334a88897701a1bbcf3626

Primary CNS lymphoma patient-derived orthotopic xenograft model capture the biological and molecular characteristics of the disease

Autor: Justine Guegan, Emmanuelle Menet, Mailys Daniau, Louis Royer-Perron, Frederic Davi, Matthieu Peyre, Khê Hoang-Xuan, Frederic Pouzoulet, Karima Mokhtari, Anne Schnitzler, Franck Assayag, Carole Soussain, Agusti Alentorn, Magali Le Garff-Tavernier, Dalila Labiod

Publikováno v: Blood Cells, Molecules, and Diseases. 75:1-10

Primary CNS lymphomas (PCNSL) are rare and poor prognosis diffuse large B-cell lymphomas. Because of the brain tumor environment and the restricted distribution of drugs in the CNS, specific PCNSL patient-derived orthotopic xenograft (PDOX) models ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f7e12ca8a36ffd5db247c1d864dd27
https://doi.org/10.1016/j.bcmd.2018.11.005

Management of primary central nervous system lymphoma

Autor: Louis Royer-Perron, Khê Hoang-Xuan

Publikováno v: La Presse Médicale. 47:e213-e244

A rare tumor, primary central nervous system lymphoma can affect immunocompetent and immunocompromised patients. While sensitive to radiotherapy or chemotherapy crossing the blood-brain barrier, it often recurs. Modern treatment consists of high-dose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2453a58a0fe3fbbd7a6e11c5922f4e0a
https://doi.org/10.1016/j.lpm.2018.04.016

Targeting the immune system in glioblastoma

Autor: Louis Royer-Perron, Agusti Alentorn, Khê Hoang-Xuan, Jean-Yves Delattre, Ahmed Idbaih, Marc Sanson, Maria Jose Ibañez-Julia, Ludovic Nguyen Them, Alberto Duran-Peña

Publikováno v: Expert Review of Precision Medicine and Drug Development. 2:121-131

Introduction: Glioblastoma (GBM) is the most aggressive primary brain cancer in adults. The standard of care of newly diagnosed GBM, including radiotherapy with concurrent and adjuvant chemotherapy with temozolomide, was established more than 10 year

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94a21876eb8d5878b7917c4041042733
https://doi.org/10.1080/23808993.2017.1309256

Identification of novel recurrent ETV6-IgH fusions in primary central nervous system lymphoma

Autor: Dominique Figarella-Branger, Franck Bielle, Clovis Adam, Louis Royer-Perron, Guillaume Gauchotte, David Meyronet, Aurélie Bruno, Chiara Villa, Amithys Rahimian, Blandine Boisselier, Carole Soussain, Fabrice Chrétien, Khê Hoang-Xuan, Caroline Houillier, Sandrine Eimer, Mailys Daniau, Frederic Davi, Karima Mokhtari, Karim Labreche, Justine Guegan, Pierre de la Grange, Agusti Alentorn, Marc Polivka, Audrey Rousseau, Frédéric Lemoine

Publikováno v: Neuro-Oncology
Neuro-Oncology, 2018, 20 (8), pp.1092-1100. ⟨10.1093/neuonc/noy019⟩
Neuro-Oncology, Oxford University Press (OUP), 2018, 20 (8), pp.1092-1100. ⟨10.1093/neuonc/noy019⟩

International audience; Background: Primary central nervous system lymphoma (PCNSL) represents a particular entity within non-Hodgkin lymphomas and is associated with poor outcome. The present study addresses the potential clinical relevance of chime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5cc9f95aaa08e9662341fc6bbe9c176
https://hal-pasteur.archives-ouvertes.fr/pasteur-02862388