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Autor:
Jin-Jun Liu, Christophe Michoud, Feng Chi, Yang Wen, Qing Xiang, Nam T. Le, Shaoqing Chen, Nicole Jackson, Jian Ping Lou, Li Chen, Chunlin Zhao, Achyutharao Sidduri, Louis Portland, Lyubomir T. Vassilev, Fred Konzelmann, Yingsi Chen, Christian Tovar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2134-2138
A novel series of quinolinyl-methylene-thiazolinones has been identified as potent and selective cyclin-dependent kinase 1 (CDK1) inhibitors. Their synthesis and structure activity relationships (SAR) are described. Representative compounds from this