Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Louis P. Conway"'
Autor:
Snehangshu Kundu, Muhammad Akhtar Ali, Niklas Handin, Louis P. Conway, Veronica Rendo, Per Artursson, Liqun He, Daniel Globisch, Tobias Sjöblom
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-19 (2021)
Abstract Background Genes in the Ras pathway have somatic mutations in at least 60 % of colorectal cancers. Despite activating the same pathway, the BRAF V600E mutation and the prevalent mutations in codon 12 and 13 of KRAS have all been linked to di
Externí odkaz:
https://doaj.org/article/c6b41f70605140fe8ae77d5c5efb4251
Autor:
Olga Eguaogie, Patrick F. Conlon, Francesco Ravalico, Jamie S. T. Sweet, Thomas B. Elder, Louis P. Conway, Marc E. Lennon, David R. W. Hodgson, Joseph S. Vyle
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 87-92 (2017)
Vibration ball-milling in a zirconia-lined vessel afforded clean and quantitative nucleophilic displacement reactions between 4-methoxybenzylthiolate salts and nucleoside 5′-halides or 5′-tosylates in five to 60 minutes. Under these conditions, c
Externí odkaz:
https://doaj.org/article/6d3b6b6007ef41de80e4fea654d64978
Autor:
Zhi-P. Cai, Louis P. Conway, Ying Y. Huang, Wen J. Wang, Pedro Laborda, Ting Wang, Ai M. Lu, Hong L. Yao, Kun Huang, Sabine L. Flitsch, Li Liu, Josef Voglmeir
Publikováno v:
Molecules, Vol 24, Iss 7, p 1368 (2019)
Sialic acids are a family of acidic monosaccharides often found on the termini of cell surface proteins or lipid glycoconjugates of higher animals. Herein we describe the enzymatic synthesis of the two isotopically labeled sialic acid derivatives d3-
Externí odkaz:
https://doaj.org/article/b7c2d064f1d940e59a4963ec6361cbba
Publikováno v:
J Am Chem Soc
Heme is an essential cofactor for many human proteins as well as the primary transporter of oxygen in blood. Recent studies have also established heme as a signaling molecule, imparting its effects through binding with protein partners rather than th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682c34afb5f37b80473abb33f733434d
https://doi.org/10.1021/jacs.2c06104
https://doi.org/10.1021/jacs.2c06104
Publikováno v:
Angewandte Chemie (International Ed. in English)
The microbiome has a fundamental impact on the human host's physiology through the production of highly reactive compounds that can lead to disease development. One class of such compounds are carbonyl‐containing metabolites, which are involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c33c1e2703f4fd8116cf53b05ab2755
https://doi.org/10.1002/anie.202107101
https://doi.org/10.1002/anie.202107101
Publikováno v:
Cell Chemical Biology. 28:371-393
The ID of disease-modifying, chemically accessible targets remains a central priority of modern therapeutic discovery. The phenotypic screening of small-molecule libraries not only represents an attractive approach to identify compounds that may serv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f2092fb60f0d9c0438f8ee8cf9d8b8
https://doi.org/10.1016/j.chembiol.2021.01.012
https://doi.org/10.1016/j.chembiol.2021.01.012
Autor:
Mário S. P. Correia, Louis P. Conway, Daniel Globisch, Ingvar A. Bergdahl, Tobias Sjöblom, Veronica Rendo
Publikováno v:
Angewandte Chemie (International Ed. in English)
N‐Acetyltransferases play critical roles in the deactivation and clearance of xenobiotics, including clinical drugs. NAT2 has been classified as an arylamine N‐acetyltransferase that mainly converts aromatic amines, hydroxylamines, and hydrazines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0797f4b8fc9827d54a0998bf787a67dc
https://doi.org/10.1002/anie.202005915
https://doi.org/10.1002/anie.202005915
Autor:
Appaso M Jadhav, Weichao Li, Louis P. Conway, Christopher G. Parker, Rick A Homan, Richard Hawkins, R. Michael Lawrence, Juanita Sanchez Rubiano
Publikováno v:
Chemical Science
The use of photo-affinity reagents for the mapping of noncovalent small molecule–protein interactions has become widespread. Recently, several ‘fully-functionalized’ (FF) chemical tags have been developed wherein a photoactivatable capture grou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef11534f31b91b416843ed42a018f06
https://pubmed.ncbi.nlm.nih.gov/34168837
https://pubmed.ncbi.nlm.nih.gov/34168837
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:955-962
Sulfatases hydrolyze sulfated metabolites to their corresponding alcohols and are present in all domains of life. These enzymes have found major application in metabolic investigation of drugs, doping control analysis and recently in metabolomics. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06eebf8df1535f146157c13970e20c89
https://doi.org/10.1016/j.bmc.2019.01.031
https://doi.org/10.1016/j.bmc.2019.01.031
Autor:
Khyle C. Richards-Corke, Seong Ho Hong, Daniel Yoo, Paramjit S. Arora, Christopher G. Parker, Louis P. Conway
Publikováno v:
Proc Natl Acad Sci U S A
Aberrant Ras signaling is linked to a wide spectrum of hyperproliferative diseases, and components of the signaling pathway, including Ras, have been the subject of intense and ongoing drug discovery efforts. The cellular activity of Ras is modulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047679ab34e65011c00d78e0154c34e5
https://pubmed.ncbi.nlm.nih.gov/33926964
https://pubmed.ncbi.nlm.nih.gov/33926964