Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Louis O'Dea"'
Autor:
Shiangtung W. Jung, Li Jung Tai, Márcia Waddington-Cruz, William J. Litchy, Sotirios Tsimikas, Peter J. Dyck, Cecilia Monteiro, Gustavo Buchele, Julian D. Gillmore, Michela Brambatti, John L. Berk, Eugene Schneider, Yukio Ando, Teresa Coelho, Morie A. Gertz, Merrill D. Benson, Nicholas J. Viney, Louis O'Dea, Richard S. Geary, Brett P. Monia, Sami Khella, Laura Obici
Publikováno v:
Neurology and therapy, vol 10, iss 1
Neurology and Therapy
Neurology and Therapy
Introduction AKCEA-TTR-LRx is a ligand-conjugated antisense (LICA) drug in development for the treatment of hereditary transthyretin amyloidosis (hATTR), a fatal disease caused by mutations in the transthyretin (TTR) gene. AKCEA-TTR-LRx shares the sa
Autor:
Louis O'Dea, Richard S. Geary, Eunju Hurh, Veronica J. Alexander, Kristin Balogh, Lynnetta Watts, Ewa Karwatowska-Prokopczuk, Sotirios Tsimikas
Publikováno v:
Nucleic Acid Therapeutics. 30:198-206
The aim of this study was to assess the effect of volanesorsen on the corrected QT (QTc) interval. This thorough QT study enrolled 52 healthy male and female subjects who were randomized at a singl...
Autor:
Linda C. Hemphill, Alberto Yataco, John P. Kane, Qingqing Yang, S.G. Hughes, Sotirios Tsimikas, Joseph L. Witztum, Robert A. Hegele, Manuel Castro-Cabezas, Robert Dufour, Steven Martin, Clinton Corder, Ulrich Julius, Seth J. Baum, Michel Krempf, James Powell, Mark Cervi, Steven Hamstead, Lawrence Galitz, Patrick M. Moriarty, Frank L.J. Visseren, Basil Issa, Traci Turner, Pankaj Vyas, Daniel Gaudet, Eunju Hurh, Erik S.G. Stroes, Peter P. Toth, Christie M. Ballantyne, Bruno Vergès, Cynthia Huffman, Jean Bergeron, Craig Thompson, Richard Shultzaberger, Ioanna Gouni-Berthold, Louis O'Dea, Cecil Murray Farrington, René Valéro, Eric Bruckert, Elisabeth Steinhagen-Thiessen, Abhay Agarwal, Letitia Thompson-Hargrave, Gordon A. Francis, Veronica J. Alexander, Richard Burdick
Publikováno v:
The Lancet Diabetes and Endocrinology, 9(5), 264-275. Elsevier BV
The Lancet. Diabetes & Endocrinology
The Lancet. Diabetes & Endocrinology, 2021, 9 (5), pp.264-275. ⟨10.1016/S2213-8587(21)00046-2⟩
The Lancet. Diabetes & Endocrinology
The Lancet. Diabetes & Endocrinology, 2021, 9 (5), pp.264-275. ⟨10.1016/S2213-8587(21)00046-2⟩
Background: Volanesorsen is an antisense oligonucleotide that targets hepatic apolipoprotein C-III synthesis and reduces plasma triglyceride concentration. The aim of this study was to explore the safety and efficacy of volanesorsen in patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0bbc0c3b73435049e18dbae3f86ae1
https://pure.amc.nl/en/publications/efficacy-and-safety-of-volanesorsen-in-patients-with-multifactorial-chylomicronaemia-compass-a-multicentre-doubleblind-randomised-placebocontrolled-phase-3-trial(2a99109c-0aba-417c-98a2-6f552441ac78).html
https://pure.amc.nl/en/publications/efficacy-and-safety-of-volanesorsen-in-patients-with-multifactorial-chylomicronaemia-compass-a-multicentre-doubleblind-randomised-placebocontrolled-phase-3-trial(2a99109c-0aba-417c-98a2-6f552441ac78).html
Autor:
Cecilia Monteiro, Qingqing Yang, Nick Viney, Arnt V. Kristen, Merrill D. Benson, Rodney H. Falk, Louis O'Dea, Brett P. Monia, Li Tai, Eugene Schneider, Mathew S. Maurer, Gustavo Buchele, Sotirios Tsimikas, Brambatti Michela, Richard S. Geary
Publikováno v:
Heart & Lung. 50:565-566
Background Transthyretin amyloidosis cardiomyopathy (ATTR-CM) is a fatal condition, leading to heart failure (HF) and ultimately death. ATTR-CM is caused by misfolding and aggregation of transthyretin (TTR), a protein produced by the liver. Depending
Autor:
Anatoly Tiulpakov, Elif Arioglu Oral, Eunju Hurh, Hartmut Schmidt, Lynnetta Watts, Louis O'Dea, Brant Hubbard, Joseph Tami, A. Garg, Ann Mertens, Veronica J. Alexander
Publikováno v:
Endocrine Abstracts.
Autor:
Hartmut Schmidt, Eunju Hurh, Louis O'Dea, Brant Hubbard, Elif Arioglu Oral, Anatoly Tiulpakov, Joseph Tami, Veronica J. Alexander, Ann Mertens, A. Garg, Lynnetta Watts
Publikováno v:
Endocrine Abstracts.
Autor:
Joyce Kingsbury, Amparo L Figueroa, Joseph L. Witztum, Walter Singleton, Louis O'Dea, Daniel Gaudet, Philip Piscitelli, Ewa Karwatowska-Prokopczuk, Sotirios Tsimikas, Seth J. Baum, Vupanorsen Study Investigators, Eunju Hurh, Richard S. Geary, Victoria J Bartlett
Publikováno v:
European heart journal. 41(40)
Aims Loss-of-function mutations in ANGPTL3 are associated with beneficial effects on lipid and glucose metabolism and reduced risk of coronary artery disease. Vupanorsen (AKCEA-ANGPTL3-L Rx ) is an N-acetyl galactosamine-conjugated antisense oligonuc
Autor:
Lynnetta M, Watts, Ewa, Karwatowska-Prokopczuk, Eunju, Hurh, Veronica J, Alexander, Kristin, Balogh, Louis, O'Dea, Richard S, Geary, Sotirios, Tsimikas
Publikováno v:
Nucleic Acid Therapeutics
The aim of this study was to assess the effect of volanesorsen on the corrected QT (QTc) interval. This thorough QT study enrolled 52 healthy male and female subjects who were randomized at a single site in a four-way crossover study. Subjects were r
Autor:
Michael Stevenson, Louis O'Dea, Handrean Soran, Marcello Arca, Paul D. Rosenblit, Andrew Hsieh
Publikováno v:
Expert Review of Cardiovascular Therapy. 16:537-546
Volanesorsen, an investigational inhibitor of apoC-III synthesis, significantly reduced triglyceride levels in clinical trials in patients with familial chylomicronemia syndrome (FCS), a rare genetic disorder characterized by marked chylomicronemia l
Autor:
Joseph L. Witztum, Richard S. Geary, Veronica J. Alexander, Eunju Hurh, Louis O'Dea, Steven G. Hughes, Sotirios Tsimikas, Shuting Xia
Publikováno v:
European heart journal, vol 40, iss 33
Aims Elevated apolipoprotein C-III (apoC-III) levels are associated with hypertriglyceridaemia and coronary heart disease. AKCEA-APOCIII-LRx is an N-acetyl galactosamine-conjugated antisense oligonucleotide targeted to the liver that selectively inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da80371eb776bf7f12691b6b57e0143f
https://escholarship.org/uc/item/9vj5m52w
https://escholarship.org/uc/item/9vj5m52w