Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Louis Nickolaus Jungheim"'
Autor:
Zahid Quyoom Bonday, Bomie Han, Louis Nickolaus Jungheim, Aiping Zhang, Marijane Russell, Kenneth Weichert, Brandon Doyle, Tarun Gheyi, Francis S. Willard, Stephen Antonysamy, J. Michael Sauder, S. Emtage, Zhanna Druzina, Charles Rauch, Robert M. Campbell, Yuewei Qian, S.R. Wasserman
Publikováno v:
Proceedings of the National Academy of Sciences. 109:17960-17965
Protein arginine methyltransferases (PRMTs) play important roles in several cellular processes, including signaling, gene regulation, and transport of proteins and nucleic acids, to impact growth, differentiation, proliferation, and development. PRMT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1554e67a125730c36253e471198761
https://doi.org/10.1073/pnas.1209814109
https://doi.org/10.1073/pnas.1209814109
Autor:
Tracy D. Self, Peter Ambrose Lander, Bryan H. Norman, Louis Nickolaus Jungheim, Jeffrey Daniel Cohen, Joseph Michael Gruber, Donald C. Paul, James J. Starling, Julian Stanley Kroin, Linda B. Tabas, Anne H. Dantzig, Daniel C. Williams, Kevin L. Law
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:5526-5530
Structure–activity relationship (SAR) studies on the tricyclic isoxazole series of MRP1 modulators have resulted in the identification of potent and selective inhibitors containing cyclohexyl-based linkers. These studies ultimately identified compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba6718b48f4849b7ad7923e0d77603d
https://doi.org/10.1016/j.bmcl.2005.08.075
https://doi.org/10.1016/j.bmcl.2005.08.075
Autor:
Brian Stephen Muehl, Silke Voelkers, Gerd Ruehter, Kenneth Jeff Thrasher, Dirk Hankotius, Hans-Juergen Mest, Soenke Petersen, Martina Berg, Grit Riedel-Herold, Jeffrey Alan Dodge, Louis Nickolaus Jungheim, Britta Evers, Mark Joseph Tebbe, Ulrike Hary, Eva-Maria Martin de la Nava, Birgit Sommer, Michael Mohr
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:6748-6762
A series of growth hormone secretagogues (GHSs) based on 2,3-dihydroisothiazole has been synthesized in the search for a potential treatment of growth hormone deficiency or frailty in the elderly. This paper describes the evaluation of the SAR of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cb0b8715764efe2ecc019ecfaafadd
https://doi.org/10.1016/j.bmc.2005.07.070
https://doi.org/10.1016/j.bmc.2005.07.070
Autor:
Robert B. Johnson, Jeffrey Daniel Cohen, Q. May Wang, Louis Nickolaus Jungheim, Elcira C. Villarreal
Publikováno v:
Antimicrobial Agents and Chemotherapy. 42:916-920
The 2A and 3C proteases encoded by human rhinoviruses (HRVs) are attractive targets for antiviral drug development due to their important roles in viral replication. Homophthalimides were originally identified as inhibitors of rhinovirus 3C protease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b408ce863e3329dd304ba93baa3db3b3
https://doi.org/10.1128/aac.42.4.916
https://doi.org/10.1128/aac.42.4.916
Autor:
Quiping Wang, JM Richardson, Robert B. Johnson, Jeffrey Daniel Cohen, GT Voy, Louis Nickolaus Jungheim
Publikováno v:
Antiviral Chemistry and Chemotherapy. 8:303-310
Rhinovirus 3C protease is an attractive target for therapeutic intervention owing to its important role in virion maturation and infectivity. In order to facilitate the identification of potential 3C protease inhibitors, we have developed a continuou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b3088d58250e03eaa3340619af80970
https://doi.org/10.1177/095632029700800402
https://doi.org/10.1177/095632029700800402
Autor:
Loncharich Richard James, Louis Nickolaus Jungheim, Q. May Wang, Jeffrey Daniel Cohen, Mark Wakulchik, Robert B. Johnson, Elcira C. Villarreal
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1589-1594
Homophthalimides 2a and 3a were found to be inhibitors of Rhinovirus 3C protease through a blind screening effort. SAR studies resulted in compound 3g, which exhibited improved enzyme inhibition, in addition to whole cell antiviral activity. Molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bed0983fcd69b332c8d045a47f21492
https://doi.org/10.1016/s0960-894x(97)00268-0
https://doi.org/10.1016/s0960-894x(97)00268-0
Autor:
S. D. Hatch, Mark A. Muesing, Penny P. Lubbehusen, Jeffrey A. Burgess, Angela J. Baxter, Louis Nickolaus Jungheim, Timothy Alan Shepherd, M. Wiskerchen
Publikováno v:
Journal of Medicinal Chemistry. 39:96-108
Noncoded D-amino acids have been designed to replace the quinaldic amide-asparaginyl moiety (P 2 /P 3 ligand) found in several potent human immunodeficiency virus (HIV) protease inhibitors such as LY289612. The substituted nitrogen, optimally an N-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a9f9eb79313b0990a7476a26a1e638
https://doi.org/10.1021/jm950576c
https://doi.org/10.1021/jm950576c
Autor:
Timothy Alan Shepherd, Angela J. Baxter, Kristina M. Campanale, Kenneth S. Su, M. Wiskerchen, John E. Munroe, J. M. Colacino, William Joseph Hornback, Mark A. Muesing, Louis Nickolaus Jungheim, S. D. Hatch
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2897-2902
Novel noncoded D-amino acids have been combined with decahydroisoquinoline, octahydrothienopyridine, and urea hydroxyethylamine isosteres to provide potent HIV-1 protease inhibitors with excellent HIV-1 antiviral activity. LY314613 shows a promising
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e306e0ed02e9c41f84a300cac5c5be94
https://doi.org/10.1016/0960-894x(95)00508-q
https://doi.org/10.1016/0960-894x(95)00508-q
Publikováno v:
Chemical Reviews. 94:1553-1566
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d31734363d3f94a6c6034067d1fc9ab
https://doi.org/10.1021/cr00030a004
https://doi.org/10.1021/cr00030a004
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1391-1396
Noncoded D-amino acids have been synthesized which effectively replace the P2/P3 ligands of the HIV-1 protease inhibitor LY289612. Several analogues are shown to have potent enzyme inhibitory and antiviral activities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7188a5eb46549ab11de228f7d831acc0
https://doi.org/10.1016/s0960-894x(01)80368-1
https://doi.org/10.1016/s0960-894x(01)80368-1