Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Louis Matty"'
Autor:
John Y. L. Chung, Louis Matty, George Zhou, Fuh-Rong Tsay, Michael H. Kress, Raymond Cvetovich, M. David Weingarten, Joseph S. Amato, Zhen Li
Publikováno v:
The Journal of Organic Chemistry. 70:8560-8563
A practical synthesis of benzisoxazole 1 and its conversion to α-aryloxyisobutyric acid 2 using 1,1,1-trichloro-2-methyl-2-propanol (chloretone) was developed. Benzisoxazole 1 was formed in high yields by the action of either methanesulfonyl chlorid
Autor:
Karen M. Conrad, Edward G. Corley, D. L. Hughes, Jacqueline H. Smitrovich, Jerry A. Murry, Genevieve N. Boice, Cecile G. Savarin, Louis Matty
Publikováno v:
Tetrahedron. 60:11367-11374
In this manuscript, an efficient synthesis of a functionalized 4-arylpiperidine is disclosed. Several synthetic approaches towards formation of the key aryl-piperidine sp3 carbon–carbon bond are discussed, including a scalable route to the piperidi
Autor:
Louis Matty, Kozo Gbewonyo, Wenjie Li, Hu Essa H, Paul J. Reider, Michel Chartrain, Daniel R. Sidler, Russell Boyd, Edward G. Corley, Jeffrey S. Campbell, Nori Ikemoto, Robert D. Larsen, Richard G. Ball, Nancy Barta
Publikováno v:
Canadian Journal of Chemistry. 80:646-652
The convergent synthesis of a potent α1A-selective adrenoceptor antagonist is described. Salient features of the synthesis include the enzymatic resolution of a racemic dihydropyrimidinone and the use of a palladium coupling reaction in the synthesi
Autor:
Ian W. Davies, Paul J. Reider, Louis Matty, Mark Taylor, Jimmy Ming-Tai Wu, David Hughes, Jean-François Marcoux
Publikováno v:
Tetrahedron Letters. 41:8021-8025
Hydrogen bromide has been demonstrated to provide optimal cis -selectivity in the reduction of 4-chromanone α-hydroxyoxime (25:1 cis / trans ) in 94% yield. This reaction is pivotal in the synthesis of cis -aminochromanol.
Autor:
Raymond J, Cvetovich, John Y L, Chung, Michael H, Kress, Joseph S, Amato, Louis, Matty, M David, Weingarten, Fuh-Rong, Tsay, Zhen, Li, George, Zhou
Publikováno v:
The Journal of organic chemistry. 70(21)
A practical synthesis of benzisoxazole 1 and its conversion to alpha-aryloxyisobutyric acid 2 using 1,1,1-trichloro-2-methyl-2-propanol (chloretone) was developed. Benzisoxazole 1 was formed in high yields by the action of either methanesulfonyl chlo
Autor:
Jacqueline H. Smitrovich, Mark A. Huffman, Joseph F. Payack, Louis Matty, Jonathan D. Rosen, James M. McNamara, Todd D. Nelson, Bridgette Craig
Publikováno v:
ChemInform. 36
Publikováno v:
The Journal of organic chemistry. 70(1)
An efficient synthesis of the potent KDR inhibitor 3-[5-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-1H-indole-2-yl]quinolin-2(1H)-one (1) is described. The process features a noncryogenic indole boronation and a dicyclohexylamine-mediated Suzuki coupl
Autor:
Mark A. Huffman, Todd D. Nelson, Jacqueline H. Smitrovich, James M. McNamara, Bridgette Craig, Joseph F. Payack, Louis Matty, Jonathan D. Rosen
Publikováno v:
Organic letters. 7(1)
The concise synthesis of a stereochemically rich hNK-1 receptor antagonist is described. The synthesis is highlighted by an S(N)2 reaction of an enantiomerically pure alpha-alkoxy sulfonate (orthogonally protected butane triol), which was prepared by
Publikováno v:
Journal of the American Chemical Society. 123(41)
Autor:
Lawrence B. Ebert, Louis Matty
Publikováno v:
Synthetic Metals. 4:345-361
Although both the true intercalation compound “C 13 CrO 3 ” and the commercially available Seloxcette graphite/chromium trioxide mixture are reduced by various inorganic reagents, only the Seloxcette is efficacious in oxidizing primary alcohols t