Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Louis Malspeis"'
Publikováno v:
Cancer Chemotherapy and Pharmacology. 48:202-208
Chloroethylnitrosoureas are among the most widely used chemotherapeutic agents for the treatment of brain tumors. SarCNU (1-(2-chloroethyl)3-sarcosinamide-1-nitrosourea) is an investigational nitrosourea analogue that has shown greater antitumor acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192aedb6d3b76db3dc3553b17277ed43
https://doi.org/10.1007/s002800100326
https://doi.org/10.1007/s002800100326
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 23:395-402
Zinc finger motifs have been found to be important in a variety of protein structures including transcription factors and viral nucleocapsid proteins. Recently, it was demonstrated that various aromatic disulfides effectively remove the metal ion fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04fc28e153f3d79258880fd05ba47a91
https://doi.org/10.1016/s0731-7085(00)00311-3
https://doi.org/10.1016/s0731-7085(00)00311-3
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 16:1301-1309
Breflate is a water soluble prodrug developed to facilitate parenteral administration of the investigational antineoplastic agent brefeldin A (BFA). Previously, using analytical methods based upon reversed-phase high performance liquid chromatography
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f63866e864e23e9fdc6c8fd7107f008
https://doi.org/10.1016/s0731-7085(97)00142-8
https://doi.org/10.1016/s0731-7085(97)00142-8
Autor:
Joseph L. Roberson, William Decker, Sherman F. Stinson, Melinda G. Hollingshead, John P. Bader, Luke A. Pallansch, Carrie Bonomi, Tim Siford, Robert Shores, Suzanne Borgel, Louis Malspeis, Robert W. Buckheit, Valerie Fliakas-Boltz, Cindy Elder
Publikováno v:
AIDS Research and Human Retroviruses. 13:789-796
A series of compounds related to oxathiin carboxanilide has been identified as nonnucleoside reverse transcriptase inhibitors (NNRTIs) of HIV-1, and structure-activity relationships have been described (Buckheit RW, et al.: Antimicrob Agents Chemothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae15a786ec40097caf66f6b99b36134
https://doi.org/10.1089/aid.1997.13.789
https://doi.org/10.1089/aid.1997.13.789
Publikováno v:
Synthetic Communications. 26:1805-1814
Two efficient syntheses of 3-chloro-7-[(chlorocarbonyl)methoxy]-4-methylcoumarin are described, one utilizing traditional chemistry starting from 3-chloro-7-hydroxy-4-methylcoumarin, while the other uses a novel reagent, sulfuryl chloride/thionyl chl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c82ce101f65aa5b76d3441ce68a85328
https://doi.org/10.1080/00397919608002622
https://doi.org/10.1080/00397919608002622
Autor:
Jeffrey G. Supko, John M. Domagala, Lori V. Coren, David J. Clanton, Catherine A. Schaeffer, William G. Rice, Louis Malspeis, Raymond C. Sowder, Lisa Graham, Susan M. Halliday, Louis E. Henderson, Rocco D. Gogliotti, Ming Bu, Larry O. Arthur, John P. Bader, Robert W. Buckheit, Jim A. Turpin
Publikováno v:
Science. 270:1194-1197
Strategies for the treatment of human immunodeficiency virus-type 1 (HIV-1) infection must contend with the obstacle of drug resistance. HIV-1 nucleocapsid protein zinc fingers are prime antiviral targets because they are mutationally intolerant and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b3366e157568905dbd9a2177df66ad
https://doi.org/10.1126/science.270.5239.1194
https://doi.org/10.1126/science.270.5239.1194
Autor:
Jeffrey G. Supko, Louis Malspeis
Publikováno v:
Antimicrobial Agents and Chemotherapy. 39:9-14
Michellamine B (MB) is a naturally occurring naphthylisoquinoline alkaloid of novel chemical structure with activity against human immunodeficiency virus (HIV) types 1 and 2 in vitro. In conjunction with its preclinical evaluation, the plasma pharmac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b59e80d23b1aea42d55e341d4d1460
https://doi.org/10.1128/aac.39.1.9
https://doi.org/10.1128/aac.39.1.9
Autor:
Jeffrey G. Supko, Louis Malspeis
Publikováno v:
Analytical Biochemistry. 216:52-60
The National Cancer Institute is pursuing preclinical development of michellamine B (MB), a novel dimeric polyhydroxylated naphthalene-tetrahydroisoquinoline alkaloid isolated from Ancistrocladus abbreviatus, as an anti-human immunodeficiency virus (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d871245a0b78bf90f15ac64960bd7db
https://doi.org/10.1006/abio.1994.1007
https://doi.org/10.1006/abio.1994.1007
Autor:
Louis Malspeis, Jeffrey G. Supko
Publikováno v:
Cancer Chemotherapy and Pharmacology. 33:325-330
Rapamycin-28-N,N-dimethylglycinate methanesulfonate salt (RG), synthesized as a potential water-soluble prodrug to facilitate parenteral administration of the antineoplastic macrolide rapamycin (RA), is active against intracranially implanted human g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c7649576eabaae805f208a90045d8e
https://doi.org/10.1007/bf00685908
https://doi.org/10.1007/bf00685908
Publikováno v:
Analytical Biochemistry. 211:16-22
The National Cancer Institute (NCI) is pursuing preclinical development of Brefeldin A (BFA), a macrolide isolated from Penicillium brefeldianum, as an antitumor agent. BFA exhibits a unique spectrum of activity against the human tumor cell line pane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75706dd18fcb239b8125279aeb78c988
https://doi.org/10.1006/abio.1993.1225
https://doi.org/10.1006/abio.1993.1225