Zobrazeno 1 - 10
of 475
pro vyhledávání: '"Louis M, Weiss"'
Autor:
Pranav Kumar, Tadakimi Tomita, Thomas A. Gerken, Collin J. Ballard, Yong Sok Lee, Louis M. Weiss, Nadine L. Samara
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Infection with the apicomplexan protozoan Toxoplasma gondii can be life-threatening in immunocompromised hosts. Transmission frequently occurs through the oral ingestion of T. gondii bradyzoite cysts, which transition to tachyzoites, dissemi
Externí odkaz:
https://doaj.org/article/38f632452ed54bc1842575fe1d9de860
Autor:
Qing Lv, Liuyi Hong, Lei Qi, Yuqing Chen, Zhengkai Xie, Hongjie Liao, Chunfeng Li, Tian Li, Xianzhi Meng, Jie Chen, Jialing Bao, Junhong Wei, Bing Han, Qingtao Shen, Louis M. Weiss, Zeyang Zhou, Mengxian Long, Guoqing Pan
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Microsporidia are obligate intracellular parasites that infect a wide variety of hosts including humans. Microsporidian spores possess a unique, highly specialized invasion apparatus involving the polar filament, polaroplast, and posterior v
Externí odkaz:
https://doaj.org/article/0f27877925b442b6a6c98762b04779f9
Autor:
Joseph Lykins, Matthew J. Moschitto, Ying Zhou, Ekaterina V. Filippova, Hoang V. Le, Tadakimi Tomita, Barbara A. Fox, David J. Bzik, Chunlei Su, Seesandra V. Rajagopala, Kristin Flores, Furio Spano, Stuart Woods, Craig W. Roberts, Cong Hua, Kamal El Bissati, Kelsey M. Wheeler, Sarah Dovgin, Stephen P. Muench, Martin McPhillie, Colin W.G. Fishwick, Wayne F. Anderson, Patricia J. Lee, Mark Hickman, Louis M. Weiss, Jitender P. Dubey, Hernan A. Lorenzi, Richard B. Silverman, Rima L. McLeod
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108477- (2024)
Summary: Toxoplasma gondii causes morbidity, mortality, and disseminates widely via cat sexual stages. Here, we find T. gondii ornithine aminotransferase (OAT) is conserved across phyla. We solve TgO/GABA-AT structures with bound inactivators at 1.55
Externí odkaz:
https://doaj.org/article/4214ce2e3d344bdb89d711a4b2786ce4
Autor:
Nicholas Rinkenberger, Alex Rosenberg, Joshua B. Radke, Jaya Bhushan, Tadakimi Tomita, Louis M. Weiss, L. David Sibley
Publikováno v:
mBio, Vol 15, Iss 1 (2024)
ABSTRACTAutophagy contributes to innate immunity by targeting intracellular pathogens for elimination. Previous studies identified a non-canonical autophagy pathway that controls Toxoplasma gondii infection in a strain-dependent manner in interferon
Externí odkaz:
https://doaj.org/article/403ad9e259624f7c9a296a7404b85e69
Autor:
Joshua Mayoral, Rebekah B. Guevara, Yolanda Rivera-Cuevas, Vincent Tu, Tadakimi Tomita, Julia D. Romano, Leslie Gunther-Cummins, Simone Sidoli, Isabelle Coppens, Vernon B. Carruthers, Louis M. Weiss
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT The intracellular parasite Toxoplasma gondii adapts to diverse host cell environments within a replicative compartment that is heavily decorated by secreted proteins. In an attempt to identify novel parasite secreted proteins that influence
Externí odkaz:
https://doaj.org/article/a0a4d9258960439ea8a171b1b9cb0df0
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Microsporidia are obligate intracellular, spore-forming parasitic fungi which are grouped with the Cryptomycota. They are both opportunistic pathogens in humans and emerging veterinary pathogens. In humans, they cause chronic diarrhea in immune-compr
Externí odkaz:
https://doaj.org/article/7541b40b6117408a83468fb10c60968c
Autor:
Tatsuki Sugi, Tadakimi Tomita, Taishi Kidaka, Naoko Kawai, Kyoko Hayashida, Louis M. Weiss, Junya Yamagishi
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Toxoplasma gondii bradyzoites establish chronic infections within their host cells. Recent studies have demonstrated that several parasite effector proteins are translocated to host cells during the bradyzoite stage of chronic infection. To understan
Externí odkaz:
https://doaj.org/article/481eeb53794f420ea3f92b49186612c2
Autor:
Claire E. Couch, Michael L. Kent, Louis M. Weiss, Peter M. Takvorian, Stephanie Nervino, Leslie Cummins, Justin L. Sanders
Publikováno v:
mSphere, Vol 7, Iss 1 (2022)
ABSTRACT A novel Enterocytozoon infection was identified in the intestines of sexually mature Chinook salmon. While microsporidian parasites are common across a diverse range of animal hosts, this novel species is remarkable because it demonstrates b
Externí odkaz:
https://doaj.org/article/f0e46a57f8d84bf699252b9a025eb24a
Autor:
Philip S. Yune, Iffath Islam, Peter V. Dicpinigaitis, Johanna P. Daily, Louis M. Weiss, Sun O. Park
Publikováno v:
Case Reports in Infectious Diseases, Vol 2022 (2022)
Babesiosis, a tick-borne protozoan disease, has been increasing in frequency in recent years. Familiarity with presentations of babesiosis is important for clinicians. Acute respiratory distress syndrome (ARDS) is a rarely seen complication of severe
Externí odkaz:
https://doaj.org/article/343272a9e8f745d6bfdd390fa3871d82
Autor:
Yolanda Rivera-Cuevas, Joshua Mayoral, Manlio Di Cristina, Anna-Lisa E Lawrence, Einar B Olafsson, Romir K Patel, Dishari Thornhill, Benjamin S Waldman, Akira Ono, Jonathan Z Sexton, Sebastian Lourido, Louis M Weiss, Vern B Carruthers
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010138 (2021)
Toxoplasma gondii is a master manipulator capable of effectively siphoning the resources from the host cell for its intracellular subsistence. However, the molecular underpinnings of how the parasite gains resources from its host remain largely unkno
Externí odkaz:
https://doaj.org/article/cd8bd035ddc44eb6a2451e248389231b