Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Louis Locco"'
Autor:
Michelle F. Homsher, Louis Locco, Shannon L. Stahler, Michael Weber, Jennifer E. Nothstein, Eleftheria N. Finger, Evelyn Boots, Mee Ra Heo, Amita Patel, Gregory O'Donnell, Alex Wolicki, Michael F.A. Finley, J. Christopher Culberson, Paul Zuck, Juncai Meng, Kenneth Roberts, David J. Bell, Peter S. Kutchukian, Gregory C. Adam, Carissa Quinn, Patrick Cocchiarella, Meir Glick, S. Alex May, Victor N. Uebele, Edward Hudak, Brian Squadroni, Daniel Riley, Andrew Rusinko, Kelli Solly, Michelle Hartnett, Dante A. Pertusi, Adam Amoss, Anthony Kreamer, Tara White, Anne Mai Wassermann
Publikováno v:
SLAS Discovery. 22:995-1006
High-throughput screening (HTS) is a widespread method in early drug discovery for identifying promising chemical matter that modulates a target or phenotype of interest. Because HTS campaigns involve screening millions of compounds, it is often desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561e5ff95861fbde45cdff3f2132d673
https://doi.org/10.1177/2472555217706058
https://doi.org/10.1177/2472555217706058
Autor:
Carlo Toniatti, Aimee L. Jackson, Michele A. Cleary, Erica Stec, Stacey Szymanski, Peter S. Linsley, Francesca Santini, Steven R. Bartz, Marc Ferrer, Berta Strulovici, Michael Carleton, Rachel H. V. Needham, Anthony Palmieri, Louis Locco
Publikováno v:
SLAS Discovery. 17:1316-1328
Gene silencing by RNA interference has become a powerful tool to help identify genes that regulate biological processes. However, the complexity of the biology probed and the incomplete validation of the reagents used make it difficult to interpret t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb291a7cc23c382aa0baeb9b1fdb64ad
https://doi.org/10.1177/1087057112453071
https://doi.org/10.1177/1087057112453071
Autor:
Louis Locco, Pei Fen Kuan, Steven R. Bartz, Anthony Kreamer, Xiaohua Douglas Zhang, Namjin Chung, Marc Ferrer, Berta Strulovici, Peter S. Linsley
Publikováno v:
SLAS Discovery. 13:149-158
High-throughput screening (HTS) of large-scale RNA interference (RNAi) libraries has become an increasingly popular method of functional genomics in recent years. Cell-based assays used for RNAi screening often produce small dynamic ranges and signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a6e54fe2594d0ed8e22c6ee1dda83f
https://doi.org/10.1177/1087057107312035
https://doi.org/10.1177/1087057107312035
Autor:
Steven R. Bartz, Peter S. Linsley, Berta Strulovici, Namjin Chung, Louis Locco, Kevin W. Huff, Marc Ferrer
Publikováno v:
SLAS Discovery. 13:142-148
RNA interference (RNAi), combined with the availability of genome sequences, provides an unprecedented opportunity for the massive and parallel investigations of gene function. Small interfering RNA (siRNA) represents a popular and quick approach of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f35e8fd6c724b891fd94f6ce38948f
https://doi.org/10.1177/1087057107312032
https://doi.org/10.1177/1087057107312032
Autor:
Milton L. Hammond, Elizabeth T. Birzin, Wanying Sun, Lovji D. Cama, Louis Locco, Ralph T. Mosley, Susan P. Rohrer, Sudha Warrier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:1468-1472
A series of 6H-benzo[c]chromen-6-one and 6H-benzo[c]chromene derivatives were prepared, and the affinity and selectivity for ERalpha and ERbeta was measured. Many of the analogs were found to be potent and selective ERbeta agonists. Bis hydroxyl at p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136f9539c753300f93daeb4160689dee
https://doi.org/10.1016/j.bmcl.2005.12.057
https://doi.org/10.1016/j.bmcl.2005.12.057
Autor:
Zhixiong Ye, Elizabeth T. Birzin, Meng-Hsin Chen, Louis Locco, Sheng-Shung Pong, Ravi P. Nargund, Rupa M. Parmar, Roy G. Smith, Ying-Duo Gao, Scott D. Feighner, Wanda W.-S. Chan, James M. Schaeffer, Arthur A. Patchett, Raman K. Bakshi, Allan D. Blake, Andrew D. Howard, Susan P. Rohrer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:5-8
Quinazolinone derivatives were synthesized and evaluated as non-peptidic growth hormone secretagogues. Modeling guided design of quinazolinone compound 21 led to a potency enhancement of greater than 200-fold compared to human growth hormone secretag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb965f4e0f30dfe4382a988470dcd5a
https://doi.org/10.1016/s0960-894x(99)00584-3
https://doi.org/10.1016/s0960-894x(99)00584-3
Publikováno v:
Biochemical Journal. 329:527-538
To investigate the mechanisms regulating polarized vesicle delivery to the cell surface in hepatocytes, we have characterized the endogenous plasma membrane (PM)-associated syntaxins. These integral membrane proteins are components of the membrane do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75739cc86bf05702810772fe41c92385
https://doi.org/10.1042/bj3290527
https://doi.org/10.1042/bj3290527
Autor:
Robert A. Liehr, Michele A. Cleary, S. Todd Smith, Alison Rush, Emily Smith, Namjin Chung, Brian S. Roberts, Anthony Kreamer, Randall T. Moon, Louis Locco, Berta Strulovici, Michael B. Major, Shane Marine, Edward Hudak, William Arthur, Marc Ferrer
Publikováno v:
Assay and drug development technologies. 8(3)
High-throughput siRNA screens are now widely used for identifying novel drug targets and mapping disease pathways. Despite their popularity, there remain challenges related to data variability, primarily due to measurement errors, biological variance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f528446eb836f1f6ae2b8882f18e716
https://pubmed.ncbi.nlm.nih.gov/20578927
https://pubmed.ncbi.nlm.nih.gov/20578927
Autor:
Julja Burchard, Anthony Palmieri, Michael Carleton, Melissa Oatley, Louis Locco, Paul Warrener, Berta Strulovici, Maki Imakura, Stephen H. Friend, Rachel H. V. Needham, Todd Smith, Peter S. Linsley, Marcia Gordon, Steven R. Bartz, Francesca Santini, Jie Guo, Zhan Zhang, Aimee L. Jackson, Melissa M. Martin, Marc Ferrer, Namjin Chung, Priya Kunapuli
Gene silencing by RNA interference is a powerful genetic tool to identify genes involved in specific biological processes in model organisms and human cells (3, 14, 18, 38, 42, 56). It is now possible to perform unbiased genetic screens using culture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08994d1c03d37004c02cb6f5c9958340
https://europepmc.org/articles/PMC1698535/
https://europepmc.org/articles/PMC1698535/
Autor:
James M. Schaeffer, E.C. Tynebor, Edward C. Hayes, R. Katz, Milton L. Hammond, Stefan Nilsson, Ralph T. Mosley, Fried Amy, Katalin Frisch, Louis Locco, Sudha W. Mitra, Kenneth J. Wildonger, Ronald W. Ratcliffe, A. Thorsell, Sheng-Jian Cai, Paula M.D. Fitzgerald, Susan P. Rohrer, Elizabeth T. Birzin, Hilary A. Wilkinson, Nandini Sharma, Robert R. Wilkening, Brian M. McKeever, M. Carlquist
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(13)
Synthesis and derivatization of a series of substituted tetrahydrofluorenone analogs giving potent, ERbeta subtype selective ligands are described. Several analogs possessing ERbeta binding affinities comparable to 17beta-estradiol but with greater t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f936311a0de6fffab7805eaa77850f92
https://pubmed.ncbi.nlm.nih.gov/16632357
https://pubmed.ncbi.nlm.nih.gov/16632357