Výsledky vyhledávání - "Louis K. Dawson"

Targeting the cyclin dependent kinase and retinoblastoma axis overcomes standard of care resistance in BRAFV600E-mutant melanoma

Autor: Svetomir N. Markovic, Samantha E. Lee, Laura A. Marlow, Michael A. Thompson, Antoneicka L. Harris, Daniel L. Small, Brandy Edenfield, Louis K. Dawson, William F. Durham, Aidan Synnott, Thomas J. Flotte, John A. Copland

Publikováno v: Oncotarget

Patient-derived tumor xenograft (PDTX) mouse models were used to discover new therapies for naive and drug resistant BRAFV600E -mutant melanoma. Tumor histology, oncogenic protein expression, and antitumor activity were comparable between patient and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1071bc9299e52c831cd579ba5869f6c4
https://doi.org/10.18632/oncotarget.23649

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Novel patient-derived xenograft mouse model for pancreatic acinar cell carcinoma demonstrates single agent activity of oxaliplatin

Autor: Robert J. Mullin, Julia Schüler, Adam C. Mathias, Daniel L. Small, Kenneth A. Meshaw, Aidan Synnott, Daniel D. Von Hoff, Steven N. Hart, William F. Durham, Laura A. Marlow, Jason C. Hall, Murli Krishna, Fergus J. Couch, John A. Copland, Louis K. Dawson, Gerardo Colon-Otero

Publikováno v: Journal of Translational Medicine

Background Pancreatic acinar cell carcinoma (PACC) is a rare malignancy, accounting for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae651dfe5fbf7de1a6c82a94956b8a5
http://europepmc.org/articles/PMC4862141

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Abstract LB-130: Tumor regression in novel triple therapy BRAF mutant metastatic melanoma patient-derived preclinical models

Autor: Svetomir N. Markovic, Daniel L. Small, Antoneicka L. Harris, John A. Copland, Michael A. Thompson, Louis K. Dawson, William F. Durham

Publikováno v: Cancer Research. 77:LB-130

Metastatic melanoma (MM) is the most aggressive type of skin cancer contributing to approximately 80% of all skin cancer related deaths. In 2016, it was estimated that more 76,000 cases would be diagnosed in the United States. The high metastatic pot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2683392cb43c9c9a01eb93638ce84c29
https://doi.org/10.1158/1538-7445.am2017-lb-130

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Abstract 1453: Methods for developing patient derived xenografts in athymic nude mice

Autor: John A. Copland, Louis K. Dawson, James L. Miller, William F. Durham, Daniel L. Small, Robert J. Mullin, Adam C. Mathias, Laura A. Marlow, Kevin J. Wu, Aidan Synnott, Brandy Edenfield

Publikováno v: Cancer Research. 75:1453-1453

Patient derived xenografts (PDX) mouse models for many types of cancer have been developed recapitulating therapeutic responses in the patient for which the PDX model was derived. Essentially, live surgically resected or biopsy tumor tissues are dire

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe098ce606fff20f390ec365ecf9b125
https://doi.org/10.1158/1538-7445.am2015-1453

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Abstract 2417: Characterization of novel patient derived melanoma xenografts and cell lines in response to targeted therapies

Autor: Dragana Milosevic, John A. Copland, Adam C. Mathias, Laura A. Marlow, Kenneth A. Meshaw, Louis K. Dawson, Brian C. Netzel, William F. Durham, Robert J. Mullin, Daniel L. Small, Stefan K.G. Grebe, Aidan Synnott, Kevin J. Wu, Svetomir N. Markovic, Antoneicka L. Harris

Publikováno v: Cancer Research. 75:2417-2417

The success of clinical trials for patients with malignant melanoma (MM) designed from the “promising” results using pre-clinical models is minimal. With its increase in incidence, there is a dire need to develop both pre-clinical models comparab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e61717c1697ab8b848edc99de59ceac
https://doi.org/10.1158/1538-7445.am2015-2417

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Abstract 1475: Therapeutic responses in a novel patient-derived xenograft mouse model for rare acinar cell pancreatic carcinoma

Autor: Adam C. Mathias, William F. Durham, Laura A. Marlow, Daniel L. Small, Kenneth A. Meshaw, Aidan Synnott, Ricardo Paz-Fumagalli, Louis K. Dawson, John A. Copland, Robert J. Mullin, Daniel D. Von Hoff, Murli Krishna, Gerardo Colon-Otero

Publikováno v: Cancer Research. 75:1475-1475

Acinar cell carcinoma of the pancreas (ACC) is an uncommon malignancy, accounting for less than 1% of all pancreatic neoplasms. Because of its rarity, only a few retrospective studies are available to help guide management. We previously reported the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::748e56e2427cd4ce0a87b02d58eaaff7
https://doi.org/10.1158/1538-7445.am2015-1475

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Abstract 1458: Characterization of novel thyroid PDX models and their response to combination therapies

Autor: William F. Durham, Dragana Milosevic, Daniel L. Small, Robert J. Mullin, Kevin J. Wu, Kenneth A. Meshaw, Aidan Synnott, John A. Copland, Robert C. Smallridge, Brian C. Netzel, Louis K. Dawson, Stefan K.G. Grebe, Adam C. Mathias, Laura A. Marlow

Publikováno v: Cancer Research. 75:1458-1458

Patient derived xenografts (PDX) mouse models for many types of cancer have demonstrated therapeutic responses similar to those seen in patients. Thus, resected patient tumor tissue directly implanted into immune compromised mice followed by therapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05f668b23377e9eb9b8655f80b309f54
https://doi.org/10.1158/1538-7445.am2015-1458

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Abstract LB-95: Estrogen receptor mRNA-directed therapy for triple-negative breast cancer

Autor: John A. Copland, Louis K. Dawson, Adam C. Mathias, Derek C. Radisky, Laura A. Marlow, James L. Miller, Christina A. von Roemeling, Beth A. Hollister, Steadman Harrison

Publikováno v: Cancer Research. 74:LB-95

Introduction: A significant number of histologically triple negative breast cancer (TNBC) cells express substantial estrogen receptor (ER) mRNA but do not express ER protein as a result of rapid proteolytic degradation. Here we assessed whether prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6309071daea9c8f900f85f7e83d73934
https://doi.org/10.1158/1538-7445.am2014-lb-95

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Abstract LB-210: Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma

Autor: John A. Copland, Thomas R. Caulfield, Beth A. Hollister, Kevin J. Wu, Adam C. Mathias, Chuck Harrison, Laura A. Marlow, Winston Tan, Christina A. von Roemeling, Han Tun, Louis K. Dawson

Publikováno v: Cancer Research. 73:LB-210

Introduction: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of RCC, which is the most prevalent kidney cancer among adults. Of the patients who develop this disease, over 1/3 will already present with advanced or metastatic disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06306a8354b71d0bac5c2b9f9f9de355
https://doi.org/10.1158/1538-7445.am2013-lb-210

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