Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Louis J. De Felice"'
Autor:
Louis J. De Felice
Publikováno v:
F1000Research, Vol 5 (2016)
Serotonin transporters (SERTs) are largely recognized for one aspect of their function—to transport serotonin back into the presynaptic terminal after its release. Another aspect of their function, however, may be to generate currents large enough
Externí odkaz:
https://doaj.org/article/0c7ae2fbd1ce49a9a8e5ef4c8ca3e42d
Autor:
Michael H. Baumann, John S. Partilla, S. Stevens Negus, Farhana Sakloth, Ernesto Solis, Kathryn L. Schwienteck, Iwona Ruchala, Louis J. De Felice, Richard A. Glennon, Jose M. Eltit
Publikováno v:
Neuropsychopharmacology. 42:1950-1961
Clandestine chemists synthesize novel stimulant drugs by exploiting structural templates known to target monoamine transporters for dopamine, norepinephrine, and serotonin (DAT, NET, and SERT, respectively). 4-Methylamphetamine (4-MA) is an emerging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a328bddfdf60d37d43eec0f2a198dc0
https://doi.org/10.1038/npp.2017.98
https://doi.org/10.1038/npp.2017.98
Autor:
Louis J. De Felice
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 468:503-511
This review focuses on the Cl(-) requirement for dopamine, serotonin, and norepinephrine (DA, 5-HT, and NE) transport and induced current via the transporters for these transmitters, DAT, SERT, and NET. Indirect evidence exists for the passage of Cl(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c1e26891f0d08dbb8db81c47ba0fa3
https://doi.org/10.1007/s00424-015-1783-4
https://doi.org/10.1007/s00424-015-1783-4
Autor:
Marvin K. Schulte, Xiaolei Pan, Douglas H. Sweet, Jose M. Eltit, Ernesto Solis, Louis J. De Felice, Kavita A. Iyer, Katie Alix, Malgorzata Dukat, Shailesh Khatri, Malaika D. Argade
Publikováno v:
Psychopharmacology. 236(7)
2-Amino-6-chloro-3,4-dihydroquinazoline (e.g., A6CDQ) represents a novel putative antidepressant originally thought to act through a 5-HT3 serotonin receptor antagonist mechanism. Here, we investigated this further by examining a positional isomer of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fadfe7909b48e38ec77bf37dc33fddc
https://pubmed.ncbi.nlm.nih.gov/30805668
https://pubmed.ncbi.nlm.nih.gov/30805668
Autor:
Louis J. De Felice
Publikováno v:
Trends in neurosciences. 40(4)
It is well established that glutamate and GABA signal through both ionotropic and metabotropic receptors. Conversely, it is thought that, with one exception, monoamines (dopamine, serotonin, and norepinephrine) signal via metabotropic receptors. Give
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdf1a76624593920e8daf5d7d2b3960
https://pubmed.ncbi.nlm.nih.gov/28318542
https://pubmed.ncbi.nlm.nih.gov/28318542
Publikováno v:
British Journal of Pharmacology. 172:4772-4774
Linked Articles This article is a Commentary on Sandtner W, Schmid D, Schicker K, Gerstbrein K, Koenig X, Mayer FP, Boehm S, Freissmuth M and Sitte HH (2014). A quantitative model of amphetamine action on the 5-HT transporter. Br J Pharmacol 171: 100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::147c7d8e90133b610b1a111ab0606879
https://doi.org/10.1111/bph.12767
https://doi.org/10.1111/bph.12767
Publikováno v:
British Journal of Pharmacology. 168:1750-1757
Background and Purpose Bath salts is the street name for drug combinations that contain synthetic cathinone analogues, among them possibly mephedrone (MEPH) and certainly methylenedioxypyrovalerone (MDPV). In animal studies, cathinone and certain cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06a92525a9d21029b74d57a4b04cec21
https://doi.org/10.1111/bph.12061
https://doi.org/10.1111/bph.12061
Publikováno v:
British Journal of Pharmacology. 165:2749-2757
BACKGROUND AND PURPOSE Wherever they are located, dopamine transporters (DATs) clear dopamine (DA) from the extracellular milieu to help regulate dopaminergic signalling. Exposure to amphetamine (AMPH) increases extracellular DA in the synaptic cleft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0c68b7b69a86b28097929f443860d9e
https://doi.org/10.1111/j.1476-5381.2011.01728.x
https://doi.org/10.1111/j.1476-5381.2011.01728.x
Autor:
Igor Zdravkovic, Sergei Y. Noskov, Louis J. De Felice, Ernesto Solis, Sandra J. Rosenthal, Ian D. Tomlinson
Publikováno v:
Journal of Biological Chemistry. 287:8852-8863
Monoamine transporters terminate synaptic neurotransmission and are molecular targets for antidepressants and psychostimulants. Fluorescent reporters can monitor real-time transport and are amenable for high-throughput screening. However, until now,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43265e7a36ae70647c465025995b8532
https://doi.org/10.1074/jbc.m111.267757
https://doi.org/10.1074/jbc.m111.267757
Autor:
Gaynor A. Larson, J. Shawn Goodwin, Louis J. De Felice, Jonathan A. Javitch, Habibeh Khoshbouei, Nancy R. Zahniser, Namita Sen, Jarod Swant
Publikováno v:
Journal of Biological Chemistry. 284:2978-2989
The psychostimulants d-amphetamine (AMPH) and methamphetamine (METH) release excess dopamine (DA) into the synaptic clefts of dopaminergic neurons. Abnormal DA release is thought to occur by reverse transport through the DA transporter (DAT), and it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8195008d8d89e5bc59ead3fe2e25e7
https://doi.org/10.1074/jbc.m805298200
https://doi.org/10.1074/jbc.m805298200