Zobrazeno 1 - 10
of 236
pro vyhledávání: '"Louis J, Picker"'
Autor:
Daniel Malouli, Meenakshi Tiwary, Roxanne M. Gilbride, David W. Morrow, Colette M. Hughes, Andrea Selseth, Toni Penney, Priscila Castanha, Megan Wallace, Yulia Yeung, Morgan Midgett, Connor Williams, Jason Reed, Yun Yu, Lina Gao, Gabin Yun, Luke Treaster, Amanda Laughlin, Jeneveve Lundy, Jennifer Tisoncik-Go, Leanne S. Whitmore, Pyone P. Aye, Faith Schiro, Jason P. Dufour, Courtney R. Papen, Husam Taher, Louis J. Picker, Klaus Früh, Michael Gale, Nicholas J. Maness, Scott G. Hansen, Simon Barratt-Boyes, Douglas S. Reed, Jonah B. Sacha
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract An influenza vaccine approach that overcomes the problem of viral sequence diversity and provides long-lived heterosubtypic protection is urgently needed to protect against pandemic influenza viruses. Here, to determine if lung-resident effe
Externí odkaz:
https://doaj.org/article/30aee6ee13914e60b17c02c57c123179
Autor:
Cheng-Jung Sung, Leanne S. Whitmore, Elise Smith, Jean Chang, Jennifer Tisoncik-Go, Aaron Barber-Axthelm, Andrea Selseth, Shana Feltham, Sohita Ojha, Scott G. Hansen, Louis J. Picker, Michael Gale
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) is a deadly infectious disease having a major impact on global health. Using the CMV vector for development of novel vaccines is a promising new strategy that elicits strong and durable, h
Externí odkaz:
https://doaj.org/article/b235f6cd8b354ad396e5a45f5c3a4336
Autor:
Benjamin Varco-Merth, Morgan Chaunzwa, Derick M Duell, Alejandra Marenco, William Goodwin, Rachel Dannay, Michael Nekorchuk, Danica Shao, Kathleen Busman-Sahay, Christine M Fennessey, Lorna Silipino, Michael Hull, William J Bosche, Randy Fast, Kelli Oswald, Rebecca Shoemaker, Rachele Bochart, Rhonda MacAllister, Caralyn S Labriola, Jeremy V Smedley, Michael K Axthelm, Miles P Davenport, Paul T Edlefsen, Jacob D Estes, Brandon F Keele, Jeffrey D Lifson, Sharon R Lewin, Louis J Picker, Afam A Okoye
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012496 (2024)
Persistence of the rebound-competent viral reservoir (RCVR) within the CD4+ T cell compartment of people living with HIV remains a major barrier to HIV cure. Here, we determined the effects of the pan-lymphocyte-depleting monoclonal antibody (mAb) al
Externí odkaz:
https://doaj.org/article/98aa0bf5a0db40c1870449c56d1dca1f
Autor:
Benjamin N. Bimber, Justine Sunshine, G. W. McElfresh, Jason S. Reed, Reese Pathak, Katherine B. Bateman, Colette M. Hughes, Roxanne M. Gilbride, Julia C. Ford, David Morrow, Jeffrey D. Lifson, Jonah B. Sacha, Scott G. Hansen, Louis J. Picker
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Simian immunodeficiency virus (SIV) vaccines based upon 68-1 Rhesus Cytomegalovirus (RhCMV) vectors show remarkable protection against pathogenic SIVmac239 challenge. Across multiple independent rhesus macaque (RM) challenge studies, nearly 60% of va
Externí odkaz:
https://doaj.org/article/e783a3dcc0a04683937ff350828c93ad
Autor:
Brandon F. Keele, Afam A. Okoye, Christine M. Fennessey, Benjamin Varco-Merth, Taina T. Immonen, Emek Kose, Andrew Conchas, Mykola Pinkevych, Leslie Lipkey, Laura Newman, Agatha Macairan, Marjorie Bosche, William J. Bosche, Brian Berkemeier, Randy Fast, Mike Hull, Kelli Oswald, Rebecca Shoemaker, Lorna Silipino, Robert J. Gorelick, Derick Duell, Alejandra Marenco, William Brantley, Jeremy Smedley, Michael Axthelm, Miles P. Davenport, Jeffrey D. Lifson, Louis J. Picker
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4 (2024)
Externí odkaz:
https://doaj.org/article/df5e85a50a9043c2bca569ca53f3f088
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundChronic CMV infection drives the clonal expansion and accumulation of terminally differentiated, dysfunctional CMV-specific T-cells. CMV infection also appears to accelerate the differentiation of non-CMV-specific T-cells; however, the exte
Externí odkaz:
https://doaj.org/article/66851b32ad6b4b89a4913f7317237d2b
Autor:
Hayden Brochu, Ruihan Wang, Tammy Tollison, Chul-Woo Pyo, Alexander Thomas, Elizabeth Tseng, Lynn Law, Louis J. Picker, Michael Gale, Daniel E. Geraghty, Xinxia Peng
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
The alternative splicing and genetic variations across the whole MHC-E locus of Rhesus Macaques (Mamu-E) are analysed, which provides a foundation for more comprehensive research of Mamu-E and informs translational research of CMV-based vaccines.
Externí odkaz:
https://doaj.org/article/ce27b75a4ef747ec83fe39c04b0d8f01
Autor:
Scott G. Hansen, Jennie L. Womack, Wilma Perez, Kimberli A. Schmidt, Emily Marshall, Ravi F. Iyer, Hillary Cleveland Rubeor, Claire E. Otero, Husam Taher, Nathan H. Vande Burgt, Richard Barfield, Kurt T. Randall, David Morrow, Colette M. Hughes, Andrea N. Selseth, Roxanne M. Gilbride, Julia C. Ford, Patrizia Caposio, Alice F. Tarantal, Cliburn Chan, Daniel Malouli, Peter A. Barry, Sallie R. Permar, Louis J. Picker, Klaus Früh
Publikováno v:
JCI Insight, Vol 8, Iss 6 (2023)
Rhesus cytomegalovirus–based (RhCMV-based) vaccine vectors induce immune responses that protect ~60% of rhesus macaques (RMs) from SIVmac239 challenge. This efficacy depends on induction of effector memory–based (EM-biased) CD8+ T cells recognizi
Externí odkaz:
https://doaj.org/article/2cef4c4bc58642d4a61f2fb76b14a405
Autor:
Françoise Haeseleer, Yoshinori Fukazawa, Haesun Park, Benjamin Varco-Merth, Blake J. Rust, Jeremy V. Smedley, Karsten Eichholz, Christopher W. Peterson, Rosemarie Mason, Hans-Peter Kiem, Mario Roederer, Louis J. Picker, Afam A. Okoye, Lawrence Corey
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 304-319 (2021)
Chimeric antigen receptor (CAR) T cell therapies are being investigated as potential HIV cures and designed to target HIV reservoirs. Monoclonal antibodies (mAbs) targeting the simian immunodeficiency virus (SIV) envelope allowed us to investigate th
Externí odkaz:
https://doaj.org/article/2e4204042ab849e8adedcd5d6bbb820e
Autor:
Benjamin D. Varco-Merth, William Brantley, Alejandra Marenco, Derick D. Duell, Devin N. Fachko, Brian Richardson, Kathleen Busman-Sahay, Danica Shao, Walter Flores, Kathleen Engelman, Yoshinori Fukazawa, Scott W. Wong, Rebecca L. Skalsky, Jeremy Smedley, Michael K. Axthelm, Jeffrey D. Lifson, Jacob D. Estes, Paul T. Edlefsen, Louis J. Picker, Cheryl M.A. Cameron, Timothy J. Henrich, Afam A. Okoye
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Proliferation of latently infected CD4+ T cells with replication-competent proviruses is an important mechanism contributing to HIV persistence during antiretroviral therapy (ART). One approach to targeting this latent cell expansion is to inhibit mT
Externí odkaz:
https://doaj.org/article/0626fdc3092c4cc489640700d2cf76b5