Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Louis Hodgson"'
Autor:
Chang Hoon Cho, Ilana Vasilisa Deyneko, Dylann Cordova-Martinez, Juan Vazquez, Anne S. Maguire, Jenny R. Diaz, Abigail U. Carbonell, Jaafar O. Tindi, Min-Hui Cui, Roman Fleysher, Sophie Molholm, Michael L. Lipton, Craig A. Branch, Louis Hodgson, Bryen A. Jordan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Heterozygous deletions in the ANKS1B gene cause ANKS1B neurodevelopmental syndrome (ANDS), a rare genetic disease characterized by autism spectrum disorder (ASD), attention deficit/hyperactivity disorder, and speech and motor deficits. The A
Externí odkaz:
https://doaj.org/article/99a952fc59a7462ba0e7c42ee97f8b9b
Autor:
Maren Hülsemann, Colline Sanchez, Polina V. Verkhusha, Vera Des Marais, Serena P. H. Mao, Sara K. Donnelly, Jeffrey E. Segall, Louis Hodgson
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-23 (2021)
Hülsemann et al. examine the role of TC10, a p21 small GTPase, in breast cancer invasion and metastasis, by regulating membrane type-1 matrix metalloproteinase (MT1- MMP) at invadopodia. The authors also develop a FRET biosensor for TC10, which is u
Externí odkaz:
https://doaj.org/article/608534c3193740aaa779560f505d5296
Autor:
Maria Al Haddad, Rayane El-Rif, Samer Hanna, Leila Jaafar, Rayanne Dennaoui, Sandra Abdellatef, Veronika Miskolci, Dianne Cox, Louis Hodgson, Mirvat El-Sibai
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-20 (2020)
Abstract Background Lung cancer is the second most commonly occurring cancer. The ability to metastasize and spread to distant locations renders the tumor more aggressive. Members of the Rho subfamily of small GTP-binding proteins (GTPases) play a ce
Externí odkaz:
https://doaj.org/article/0b319368d53a441ea31896eff857c9af
Autor:
Taras A. Redchuk, Maksim M. Karasev, Polina V. Verkhusha, Sara K. Donnelly, Maren Hülsemann, Jori Virtanen, Henna M. Moore, Maria K. Vartiainen, Louis Hodgson, Vladislav V. Verkhusha
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Optogenetic approaches to control protein-protein interactions usually require overexpression of the target proteins. Here the authors integrate intrabodies into near-infrared- and blue-light activatable optogenetic tools to control endogenous protei
Externí odkaz:
https://doaj.org/article/6f20a13284cc4e2a9ddb3638c37c57ca
Autor:
Sandra Abdellatef, Isabelle Fakhoury, Maria Al Haddad, Leila Jaafar, Hiba Maalouf, Samer Hanna, Bassem Khalil, Zeinab El Masri, Louis Hodgson, Mirvat El-Sibai
Publikováno v:
European Journal of Cell Biology, Vol 101, Iss 1, Pp 151197- (2022)
Metastasis remains the main challenge to overcome for treating ovarian cancers. In this study, we investigate the potential role of the Cdc42 GAP StarD13 in the modulation of cell motility, invasion in ovarian cancer cells. StarD13 depletion does not
Externí odkaz:
https://doaj.org/article/c030646bb245450f846b4f07b00e9590
Autor:
Katrina M. Wisdom, Kolade Adebowale, Julie Chang, Joanna Y. Lee, Sungmin Nam, Rajiv Desai, Ninna Struck Rossen, Marjan Rafat, Robert B. West, Louis Hodgson, Ovijit Chaudhuri
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
In order to metastasize, cancer cells must migrate through basement membranes and dense stroma, and proteases are thought to be required due to the confining nature of these matrices. Here the authors use synthetic matrices to show that cells can mig
Externí odkaz:
https://doaj.org/article/98c929b92b67496b9f803a21d27ece3c
Autor:
Maren Hülsemann, Colline Sanchez, Polina V. Verkhusha, Vera Des Marais, Serena P. H. Mao, Sara K. Donnelly, Jeffrey E. Segall, Louis Hodgson
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/f061cad9afe14439a0a36f230e31c23a
Autor:
Jessica Aijia Liu, Yanxia Rao, May Pui Lai Cheung, Man-Ning Hui, Ming-Hoi Wu, Lo-Kong Chan, Irene Oi-Lin Ng, Ben Niu, Kathryn S. E. Cheah, Rakesh Sharma, Louis Hodgson, Martin Cheung
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Following epithelial-mesenchymal transition, avian trunk neural crest cell polarity determines directional migration but how this is established is unclear. Here, the authors find that the RhoGAP, Deleted in liver cancer 1, is asymmetrically localize
Externí odkaz:
https://doaj.org/article/d5afe614c7da4570bdef1328892dfbb0
Autor:
Samer J. Hanna, Kessler McCoy-Simandle, Veronika Miskolci, Peng Guo, Michael Cammer, Louis Hodgson, Dianne Cox
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract Macrophage interactions with other cells, either locally or at distances, are imperative in both normal and pathological conditions. While soluble means of communication can transmit signals between different cells, it does not account for a
Externí odkaz:
https://doaj.org/article/c22aca1e9c2c436fabe48b56c8490450
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96469 (2014)
Cdc42 is critical in a myriad of cellular morphogenic processes, requiring precisely regulated activation dynamics to affect specific cellular events. To facilitate direct observations of Cdc42 activation in live cells, we developed and validated a n
Externí odkaz:
https://doaj.org/article/ec49bde8e0f9431890386f7db6d26437