Enhanced dimethylarginine degradation improves coronary flow reserve and exercise tolerance in Duchenne muscular dystrophy carrier mice

Autor: Louis G. D'Alecy, Kaitlynn V. Bayne, Daniel E. Michele, Lauren E. Merz, Sara Schrade, Ashley J. Cuttitta, Kimber Converso-Baran, Steven E. Whitesall, Joanne F. Garbincius, Emily A. Armstead

Publikováno v: Am J Physiol Heart Circ Physiol

Duchenne muscular dystrophy (DMD) is an X-linked disease caused by null mutations in dystrophin and characterized by muscle degeneration. Cardiomyopathy is common and often prevalent at similar frequency in female DMD carriers irrespective of whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1515aef69d522dba8d6e4ed60e132fd4
https://doi.org/10.1152/ajpheart.00333.2019

Dietary Protein and Amino Acid Deficiency Inhibit Pancreatic Digestive Enzyme mRNA Translation by Multiple Mechanisms

Autor: John A. Williams, Nancy L. Vogel, Maria Dolors Sans, Louis G. D'Alecy, Stephen J. Crozier

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 99-115 (2021)

Background & Aims Chronic amino acid (AA) deficiency, as in kwashiorkor, reduces the size of the pancreas through an effect on mammalian target of rapamycin complex 1 (mTORC1). Because of the physiological importance of AAs and their role as a substr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bdfa7077fd78998f54db32a754523b3
https://pubmed.ncbi.nlm.nih.gov/32735995

Abstract 415: Transgenic Expression of Dimethylarginine Dimethylaminohydrolase Attenuates Exercise-induced Fatigue in Duchenne Muscular Dystrophy Carrier Mice

Autor: Joanne F Garbincius, Lauren E Merz, Ashley J Cuttita, Kaitlynn V Bayne, Sara Schrade, Emily A Armstead, Kimber L Converso-Baran, Steven E Whitesall, Louis G D’Alecy, Daniel E Michele

Publikováno v: Circulation Research. 121

Duchenne muscular dystrophy (DMD) is an X-linked disease caused by mutations in dystrophin and characterized by muscle degeneration, cardiomyopathy, and impaired muscle nitric oxide (NO) production that disrupts muscle blood flow regulation and leads

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd561071b9e5d866c9e10bac05543a3f
https://doi.org/10.1161/res.121.suppl_1.415

Pathogenic Cycle Between the Endogenous Nitric Oxide Synthase Inhibitor Asymmetrical Dimethylarginine and the Leukocyte-Derived Hemoprotein Myeloperoxidase

Autor: Dimitrios Tsikas, Karsten Sydow, Jan T. Kielstein, Michaela Pekarova, Crystal A. Gadegbeku, Lukáš Kubala, Stefan Blankenberg, Renke Maas, Louis G. D'Alecy, Robin Schmidt-Haupt, Stephan Willems, Natalie Lund, Jessica L. Slocum, Denise Lau, Rainer H. Böger, Olaf J C Hellwinkel, Dorothee Atzler, Anna Klinke, Edzard Schwedhelm, Eike Christin Von Leitner, Thomas Meinertz, Stephan Baldus, Heimo Ehmke

Publikováno v: Circulation. 124:2735-2745

Background— The nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) and the leukocyte-derived hemoprotein myeloperoxidase (MPO) are associated with cardiovascular diseases. Activation of monocytes and polymorphonuclear neutrophils

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23711ce8ef1d87d35892abf59933cf1
https://doi.org/10.1161/circulationaha.111.060541

Direct monitoring pressure overload predicts cardiac hypertrophy in mice

Autor: Louis G. D'Alecy, Richard M. Mortensen, Steven E. Whitesall, Christine Y. Ivashchenko, Sheng-Zhong Duan

Publikováno v: Physiological Measurement. 28:1329-1339

Pressure overload (POL) is a classical model for studying cardiac hypertrophy, but there has been no direct measure of hemodynamics in a conscious ambulatory mouse model of POL. We used abdominal aortic constriction to produce POL and radiotelemetry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48275e6ad03af4d55d8700fe037af64
https://doi.org/10.1088/0967-3334/28/11/001