Dietary Protein and Amino Acid Deficiency Inhibit Pancreatic Digestive Enzyme mRNA Translation by Multiple MechanismsSummary

Autor: Maria Dolors Sans, Stephen J. Crozier, Nancy L. Vogel, Louis G. D’Alecy, John A. Williams

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 99-115 (2021)

Background & Aims: Chronic amino acid (AA) deficiency, as in kwashiorkor, reduces the size of the pancreas through an effect on mammalian target of rapamycin complex 1 (mTORC1). Because of the physiological importance of AAs and their role as a subst

Externí odkaz: https://doaj.org/article/8aab067fbdee405d89fb286e531b60d6

Dietary Protein and Amino Acid Deficiency Inhibit Pancreatic Digestive Enzyme mRNA Translation by Multiple Mechanisms

Autor: John A. Williams, Nancy L. Vogel, Maria Dolors Sans, Louis G. D'Alecy, Stephen J. Crozier

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 99-115 (2021)

Background & Aims Chronic amino acid (AA) deficiency, as in kwashiorkor, reduces the size of the pancreas through an effect on mammalian target of rapamycin complex 1 (mTORC1). Because of the physiological importance of AAs and their role as a substr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bdfa7077fd78998f54db32a754523b3
https://pubmed.ncbi.nlm.nih.gov/32735995

Abstract 415: Transgenic Expression of Dimethylarginine Dimethylaminohydrolase Attenuates Exercise-induced Fatigue in Duchenne Muscular Dystrophy Carrier Mice

Autor: Joanne F Garbincius, Lauren E Merz, Ashley J Cuttita, Kaitlynn V Bayne, Sara Schrade, Emily A Armstead, Kimber L Converso-Baran, Steven E Whitesall, Louis G D’Alecy, Daniel E Michele

Publikováno v: Circulation Research. 121

Duchenne muscular dystrophy (DMD) is an X-linked disease caused by mutations in dystrophin and characterized by muscle degeneration, cardiomyopathy, and impaired muscle nitric oxide (NO) production that disrupts muscle blood flow regulation and leads

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd561071b9e5d866c9e10bac05543a3f
https://doi.org/10.1161/res.121.suppl_1.415

Pathogenic Cycle Between the Endogenous Nitric Oxide Synthase Inhibitor Asymmetrical Dimethylarginine and the Leukocyte-Derived Hemoprotein Myeloperoxidase

Autor: Dimitrios Tsikas, Karsten Sydow, Jan T. Kielstein, Michaela Pekarova, Crystal A. Gadegbeku, Lukáš Kubala, Stefan Blankenberg, Renke Maas, Louis G. D'Alecy, Robin Schmidt-Haupt, Stephan Willems, Natalie Lund, Jessica L. Slocum, Denise Lau, Rainer H. Böger, Olaf J C Hellwinkel, Dorothee Atzler, Anna Klinke, Edzard Schwedhelm, Eike Christin Von Leitner, Thomas Meinertz, Stephan Baldus, Heimo Ehmke

Publikováno v: Circulation. 124:2735-2745

Background— The nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) and the leukocyte-derived hemoprotein myeloperoxidase (MPO) are associated with cardiovascular diseases. Activation of monocytes and polymorphonuclear neutrophils

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23711ce8ef1d87d35892abf59933cf1
https://doi.org/10.1161/circulationaha.111.060541

Direct monitoring pressure overload predicts cardiac hypertrophy in mice

Autor: Louis G. D'Alecy, Richard M. Mortensen, Steven E. Whitesall, Christine Y. Ivashchenko, Sheng-Zhong Duan

Publikováno v: Physiological Measurement. 28:1329-1339

Pressure overload (POL) is a classical model for studying cardiac hypertrophy, but there has been no direct measure of hemodynamics in a conscious ambulatory mouse model of POL. We used abdominal aortic constriction to produce POL and radiotelemetry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48275e6ad03af4d55d8700fe037af64
https://doi.org/10.1088/0967-3334/28/11/001