Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Louis Dubeau"'
Autor:
Shaun Haran, Kantaraja Chindera, May Sabry, Nafisa Wilkinson, Rupali Arora, Agnieszka Zubiak, Thomas E. Bartlett, Iona Evans, Allison Jones, Daniel Reisel, Chiara Herzog, Twana Alkasalias, Mark Newman, Jaeyeon Kim, Angelique Flöter Rådestad, Kristina Gemzell-Danielsson, Adam N. Rosenthal, Louis Dubeau, Mark W. Lowdell, Martin Widschwendter
Publikováno v:
Cancers, Vol 16, Iss 6, p 1186 (2024)
Background: Tissue-specificity for fimbrial fallopian tube ovarian carcinogenesis remains largely unknown in BRCA1 mutation carriers. We aimed to assess the cell autonomous and cell-nonautonomous implications of a germline BRCA1 mutation in the conte
Externí odkaz:
https://doaj.org/article/73dbf2facb5a4ee18d1d528b08e456f4
Autor:
Thomas E. Bartlett, Iona Evans, Allison Jones, James E. Barrett, Shaun Haran, Daniel Reisel, Kiriaki Papaikonomou, Louise Jones, Chiara Herzog, Nora Pashayan, Bruno M. Simões, Robert B. Clarke, D. Gareth Evans, Talayeh S. Ghezelayagh, Sakthivignesh Ponandai-Srinivasan, Nageswara R. Boggavarapu, Parameswaran G. Lalitkumar, Sacha J. Howell, Rosa Ana Risques, Angelique Flöter Rådestad, Louis Dubeau, Kristina Gemzell-Danielsson, Martin Widschwendter
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-18 (2022)
Abstract Background Breast cancer is a leading cause of death in premenopausal women. Progesterone drives expansion of luminal progenitor cells, leading to the development of poor-prognostic breast cancers. However, it is not known if antagonising pr
Externí odkaz:
https://doaj.org/article/3c4f667ea36343489d62c2a38deb1ee7
Autor:
Dat P. Ha, Woo-Jin Shin, Juan Carlos Hernandez, Nouri Neamati, Louis Dubeau, Keigo Machida, Amy S. Lee
Publikováno v:
Viruses, Vol 15, Iss 5, p 1118 (2023)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the COVID-19 pandemic, has given rise to many new variants with increased transmissibility and the ability to evade vaccine protection. The 78-kDa glucose-regula
Externí odkaz:
https://doaj.org/article/0bd264f74cc74dc6a79e9fc4c1b6feb7
Autor:
Thomas E. Bartlett, Iona Evans, Allison Jones, James E. Barrett, Shaun Haran, Daniel Reisel, Kiriaki Papaikonomou, Louise Jones, Chiara Herzog, Nora Pashayan, Bruno M. Simões, Robert B. Clarke, D. Gareth Evans, Talayeh S. Ghezelayagh, Sakthivignesh Ponandai-Srinivasan, Nageswara R. Boggavarapu, Parameswaran G. Lalitkumar, Sacha J. Howell, Rosa Ana Risques, Angelique Flöter Rådestad, Louis Dubeau, Kristina Gemzell-Danielsson, Martin Widschwendter
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/e33dc40c9a65449694cb3d0e780845d4
Autor:
Soma Samanta, Shuzo Tamura, Louis Dubeau, Paulette Mhawech-Fauceglia, Yohei Miyagi, Hisamori Kato, Rich Lieberman, Ronald J. Buckanovich, Yvonne G. Lin, Nouri Neamati
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Epithelial ovarian cancer (EOC) is a leading cause of cancer-related mortality in the United States due to the late-stage disease at diagnosis. Overexpression of GRP78 and PDI following endoplasmic reticulum (ER) stress and activation of the
Externí odkaz:
https://doaj.org/article/dd57821e5b494d9885f7af2c08ad84ce
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The two homologous estrogen receptors ERα and ERβ exert distinct effects on their cognate tissues. Previous work from our laboratory identified an ERβ-specific phosphotyrosine residue that regulates ERβ transcriptional activity and antitumor func
Externí odkaz:
https://doaj.org/article/c8f8925423504c20b68483477628400d
Publikováno v:
Epigenetics, Vol 13, Iss 10-11, Pp 1027-1038 (2018)
AXL is one of the TAM (TYRO3, AXL and MERTK) receptor tyrosine kinases and may be involved in airway inflammation. Little is known about how epigenetic changes in AXL may affect lung development during adolescence. We investigated the association bet
Externí odkaz:
https://doaj.org/article/32dddf9248364388b4a933e7edd033d8
Autor:
Lu Gao, Xiaochen Liu, Joshua Millstein, Kimberly D. Siegmund, Louis Dubeau, Rachel L. Maguire, Junfeng (Jim) Zhang, Bernard F. Fuemmeler, Scott H. Kollins, Cathrine Hoyo, Susan K. Murphy, Carrie V. Breton
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-11 (2018)
Abstract Background Epigenetic modifications, including DNA methylation, act as one potential mechanism underlying the detrimental effects associated with prenatal tobacco smoke (PTS) exposure. Methylation in a gene called AXL was previously reported
Externí odkaz:
https://doaj.org/article/4a179f99abf14c6ea21c7571f8c92666
Autor:
Lu Gao, Joshua Millstein, Kimberly D. Siegmund, Louis Dubeau, Rachel Maguire, Frank D. Gilliland, Susan K. Murphy, Cathrine Hoyo, Carrie V. Breton
Publikováno v:
Clinical Epigenetics, Vol 9, Iss 1, Pp 1-13 (2017)
Abstract Background AXL is one of the TAM (TYRO3, AXL and MERTK) receptor tyrosine kinases and may affect numerous immune-related health conditions. However, the role for AXL in asthma, including its epigenetic regulation, has not been extensively st
Externí odkaz:
https://doaj.org/article/d73d4f0edc3c4bf19441d2a6671b695e
Autor:
Thomas E. Bartlett, Kantaraja Chindera, Jacqueline McDermott, Charles E. Breeze, William R. Cooke, Allison Jones, Daniel Reisel, Smita T. Karegodar, Rupali Arora, Stephan Beck, Usha Menon, Louis Dubeau, Martin Widschwendter
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Women with germline variants in BRCA genes are predisposed to ovarian cancer. In this study, the authors demonstrate that fimbrial tissue from the ovary, the site of ovarian cancer, in BRCAmutant carriers contains marked DNA methylation changes compa
Externí odkaz:
https://doaj.org/article/c0f2825e826f439a82d6b3c7a397ac25