Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Louis DiDone"'
Autor:
Arielle Butts, Jennifer A Martin, Louis DiDone, Erin K Bradley, Mitchell Mutz, Damian J Krysan
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125927 (2015)
Cryptococcosis is one of the most important invasive fungal infections and is a significant contributor to the mortality associated with HIV/AIDS. As part of our program to repurpose molecules related to the selective estrogen receptor modulator (SER
Externí odkaz:
https://doaj.org/article/d788779a16c84687bcf4f7424a3d50c4
Autor:
Lauren Forbes, Katherine Ebsworth-Mojica, Louis DiDone, Shao-Gang Li, Joel S Freundlich, Nancy Connell, Paul M Dunman, Damian J Krysan
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129234 (2015)
Mycobacterium tuberculosis (Mtb) is well-established to be one of the most important bacterial pathogens for which new antimicrobial therapies are needed. Herein, we describe the development of a high throughput screening assay for the identification
Externí odkaz:
https://doaj.org/article/060bff0cd9594b89817399735d136871
Autor:
Arielle Butts, Kristy Koselny, Yeissa Chabrier-Roselló, Camile P. Semighini, Jessica C. S. Brown, Xuying Wang, Sivakumar Annadurai, Louis DiDone, Julie Tabroff, Wayne E. Childers, Magid Abou-Gharbia, Melanie Wellington, Maria E. Cardenas, Hiten D. Madhani, Joseph Heitman, Damian J. Krysan
Publikováno v:
mBio, Vol 5, Iss 1 (2014)
ABSTRACT Cryptococcosis is an infectious disease of global significance for which new therapies are needed. Repurposing previously developed drugs for new indications can expedite the translation of new therapies from bench to beside. Here, we charac
Externí odkaz:
https://doaj.org/article/a47f62ddda0341948a47a260086195b2
Autor:
Melanie T. Cushion, Justin P. Halterman, Kristy Koselny, Thomas F. Patterson, Nathan P. Wiederhold, Annette W. Fothergill, Damian J. Krysan, Chad Rappelye, Louis DiDone, Melanie Wellington, Julianne Green
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:7115-7127
Only one new class of antifungal drugs has been introduced into clinical practice in the last 30 years, and thus the identification of small molecules with novel mechanisms of action is an important goal of current anti-infective research. Here, we d
Autor:
Stuart L. Schreiber, Philip N. Moquist, Michelle Palmer, Louis DiDone, Jun Pu, Sivaraman Dandapani, Damian J. Krysan, Kate Hartland, Benito Munoz
Publikováno v:
ACS Infectious Diseases
Cryptococcus neoformans is one of the most important human fungal pathogens; however, no new therapies have been developed in over 50 years. Fungicidal activity is crucially important for an effective anticryptococal agent and, therefore, we screened
Publikováno v:
ACS Infect Dis
New classes of antifungal drugs are an urgent un-met clinical need. One approach to the challenge of developing new antifungal drugs is to optimize the antifungal properties of currently used drugs with favorable pharmacologic properties, so-called d
Autor:
Madeline K. Sofia, Paul M. Dunman, Jennielle Jobson, Anna C. Jacobs, Damian J. Krysan, Louis DiDone
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:26-36
Adenylate kinase (AK) is a ubiquitous intracellular enzyme that is released into the extracellular space upon cell lysis. We have shown that AK release serves as a useful reporter of bactericidal agent activity and can be exploited for antimicrobial
Autor:
Jennifer M. Colquhoun, Kaitlyn L. Norman, Anuj Kumar, Jeremy W. Schroeder, Sarah Saputo, Brooke N. Horton, Thomas Murante, Lyle A. Simmons, Damian J. Krysan, Louis DiDone, Jacinto De La Cruz Diaz
Although the analysis of genetic interactions and networks is a powerful approach to understanding biology, it has not been applied widely to the pathogenic yeast Candida albicans. Here, we describe the use of both screening and directed genetic inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e09bf39e65aa1df0623903c85570c4
https://europepmc.org/articles/PMC4937472/
https://europepmc.org/articles/PMC4937472/
Autor:
Damian J. Krysan, Louis DiDone, Virginia E. Glazier, Kristy Koselny, Julianne Green, Shea Ransford, Lacey Favazzo
Publikováno v:
ACS Infectious Diseases
AR-12/OSU-03012 is an antitumor celecoxib-derivative that has progressed to Phase I clinical trial as an anticancer agent and has activity against a number of infectious agents including fungi, bacteria and viruses. However, the mechanism of these ac
Publikováno v:
Eukaryotic Cell. 9:1669-1679
Eukaryotic cells employ a variety of mechanisms to maintain protein quality control and homeostasis. Here we provide evidence that one such mechanism in Saccharomyces cerevisiae involves the regulated release of excess or misfolded proteins to the ex