Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Louis De Muynck"'
Autor:
Karen Y. He, Ekaterina A. Khramtsova, Alfredo Cabrera-Socorro, Yanfei Zhang, Shuwei Li, Brice A. J. Sarver, Bart Smets, Qingqin S. Li, Louis De Muynck, Antonio R. Parrado, Simon Lovestone, Mary Helen Black
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/963aba3c0f6644fe9e74f893f8ec0328
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-12 (2023)
Abstract Heparan sulfates (HS) proteoglycans are commonly found on the cell surface and mediate many processes. Binding of HS ligands is determined by the sulfation code on the HS chain that can be N-/2-O/6-O- or 3-O-sulfated, generating heterogenous
Externí odkaz:
https://doaj.org/article/fd58fc4c6f934d1582988d774eef5901
Autor:
Andreia Ferreira, Ines Royaux, Jian Liu, Zhangjie Wang, Guowei Su, Diederik Moechars, Nico Callewaert, Louis De Muynck
Publikováno v:
BMC Molecular and Cell Biology, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Considering the high correlation between the functional decline in Alzheimer’s disease (AD) and the propagation of aggregated tau protein, many research efforts are focused on determining the underlying molecular mechanisms of t
Externí odkaz:
https://doaj.org/article/b9e92926410c468e9d4f36af35a786e8
Autor:
Qingqin S. Li, Louis De Muynck
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 13, Iss , Pp 100227- (2021)
Background: Alzheimer’s disease (AD) is associated with abnormal tau and amyloid-β accumulation in the brain, leading to neurofibrillary tangles, neuropil threads and extracellular amyloid-β plaques. Treatment is limited to symptom management, a
Externí odkaz:
https://doaj.org/article/1012b67b486d48e68559993a513f2f0c
Autor:
Lien Veys, Jessie Van houcke, Jeroen Aerts, Sophie Van Pottelberge, Michel Mahieu, Audrey Coens, Ronald Melki, Dieder Moechars, Louis De Muynck, Lies De Groef
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2021)
Although very different in etiology and symptoms, numerous neurodegenerative diseases can be classified as proteinopathies. More so, evidence indicates that the key misfolded proteins at the basis of different neuropathies might share common mechanis
Externí odkaz:
https://doaj.org/article/bbe320cb208e42e49fedff55771c3610
Autor:
An Verheyen, Annick Diels, Joke Reumers, Kirsten Van Hoorde, Ilse Van den Wyngaert, Constantin van Outryve d’Ydewalle, An De Bondt, Jacobine Kuijlaars, Louis De Muynck, Ronald De Hoogt, Alexis Bretteville, Steffen Jaensch, Arjan Buist, Alfredo Cabrera-Socorro, Selina Wray, Andreas Ebneth, Peter Roevens, Ines Royaux, Pieter J. Peeters
Publikováno v:
Stem Cell Reports, Vol 11, Iss 2, Pp 363-379 (2018)
Summary: Tauopathies such as frontotemporal dementia (FTD) remain incurable to date, partially due to the lack of translational in vitro disease models. The MAPT gene, encoding the microtubule-associated protein tau, has been shown to play an importa
Externí odkaz:
https://doaj.org/article/301136220c5f4b20bc2ad49e591d873f
Autor:
Susanna Raitano, Laura Ordovàs, Louis De Muynck, Wenting Guo, Ira Espuny-Camacho, Martine Geraerts, Satish Khurana, Kim Vanuytsel, Balazs I. Tóth, Thomas Voets, Rik Vandenberghe, Toni Cathomen, Ludo Van Den Bosch, Pierre Vanderhaeghen, Philip Van Damme, Catherine M. Verfaillie
Publikováno v:
Stem Cell Reports, Vol 4, Iss 1, Pp 16-24 (2015)
Summary: To understand how haploinsufficiency of progranulin (PGRN) causes frontotemporal dementia (FTD), we created induced pluripotent stem cells (iPSCs) from patients carrying the GRNIVS1+5G > C mutation (FTD-iPSCs). FTD-iPSCs were fated to cortic
Externí odkaz:
https://doaj.org/article/28a1256a71594187b980295e38763bb6
Autor:
Angela S Laird, Annelies Van Hoecke, Louis De Muynck, Mieke Timmers, Ludo Van den Bosch, Philip Van Damme, Wim Robberecht
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13368 (2010)
Mislocalization, aberrant processing and aggregation of TAR DNA-binding protein 43 (TDP-43) is found in the neurons affected by two related diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal lobe dementia (FTLD). These TDP-43 abnormalit
Externí odkaz:
https://doaj.org/article/086a0d1968dd4a568bf5e6b623a27965
Autor:
Karen Y. He, Ekaterina A. Khramtsova, Alfredo Cabrera-Socorro, Yanfei Zhang, Shuwei Li, Brice A. J. Sarver, Bart Smets, Qingqin S. Li, Louis De Muynck, Antonio R. Parrado, Simon Lovestone, Mary Helen Black
ImportanceA few case studies have reported the APOE Christchurch (APOECh) variant to confer protective effects for Alzheimer’s disease (AD) and a higher risk of premature cardiovascular disease (CVD). However, these studies primarily focused on a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8150e221f6b14586af35050c753501b0
https://doi.org/10.1101/2022.12.05.22283048
https://doi.org/10.1101/2022.12.05.22283048
Autor:
Philip Van Damme, Peter C. van Rijen, Louis De Muynck, Rachel Kleinloog, Jelkje J. de Boer-Bergsma, Jan Willem Berkelbach van der Sprenkel, Gerard A. P. de Kort, Allard J. Hauer, Patrick Deelen, Morris A. Swertz, Fabrizio Giuliani, Peter H. Gosselaar, Gabriel J.E. Rinkel, Albert van der Zwan, Catharina J.M. Klijn, Jan H. Veldink, Ynte M. Ruigrok
Publikováno v:
Stroke, 51(1), 268-274. LIPPINCOTT WILLIAMS & WILKINS
Stroke, 51, 1, pp. 268-274
Stroke, 51, 268-274
Stroke, 51, 1, pp. 268-274
Stroke, 51, 268-274
Background and Purpose— Interventional treatment of unruptured brain arteriovenous malformations (BAVMs) has become increasingly controversial. Because medical therapy is still lacking, we aimed to obtain insight into the disease mechanisms implica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a90c3255eb3e5c1c9a9c2c16ffa97c
https://hdl.handle.net/11370/8723ba09-0b37-4095-86ad-4c333bde4119
https://hdl.handle.net/11370/8723ba09-0b37-4095-86ad-4c333bde4119