Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Louis Christodoulou"'
Autor:
Alison Eddleston, Kevin Greenslade, Kerry Louise Tyson, Bryan Smith, Anthony Shock, Daniel John Lightwood, Louis Christodoulou, Frank R. Brennan, Alison Clargo
Publikováno v:
International Immunopharmacology. 66:362-365
Primary immune thrombocytopenia (ITP) is an autoimmune disease characterized by pathogenic immunoglobulin G (IgG) autoantibodies that bind to platelets, causing their phagocytic removal and leading to reductions in platelet number. The neonatal Fc re
Autor:
Paul Atherfold, Hanna Hailu, Louis Christodoulou, Lena E. D’Hooghe, Bryan Smith, Helene Margaret Finney, Frank R. Brennan, Stevan Shaw, Kerry Louise Tyson, Daniel John Lightwood, Andrea Kiessling, Kevin Greenslade, Omar Qureshi, Lara Kevorkian, Rebecca Munro, Kate L. Dixon, Rocio Lledo-Garcia, Shauna West, Christoph Meier, Matthew C. Catley, Kaushik Sarkar, Alison Turner, Roohi Tewari, Sophie P. Shaw
Publikováno v:
mAbs
Rozanolixizumab (UCB7665), a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P), has been developed to reduce pathogenic IgG in autoimmune and alloimmune diseases. We document the antibody isolation and compare
Autor:
Kevin Greenslade, H Björkelund, Alison Eddleston, Bryan Smith, Jay Tibbitts, S Crilly, F Junker, Michael D.J. Parkinson, Andrea Kiessling, Robert J. Griffin, Joanne E. Compson, Katharine Cain, Omar Qureshi, Frank R. Brennan, David P. Humphreys, Shirley Jane Peters, Farnaz Fallah-Arani, M Malmqvist, Louis Christodoulou, Nicola L. Davies, L Staelens, E. Ward, Tania F. Rowley, Thomas L. Pither
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports
Engagement of Fcγ-receptors triggers a range of downstream signalling events resulting in a diverse array of immune functions. As a result, blockade of Fc-mediated function is an important strategy for the control of several autoimmune and inflammat
Publikováno v:
IEEE Transactions on Broadcasting. 63:656-672
The era of ubiquitous access to a rich selection of interactive and high quality multimedia has begun; with it, significant challenges in data demand have been placed on mobile network technologies. Content creators and broadcasters alike have embrac
Autor:
Alastair D. G. Lawson, Ralph Adams, Joanne E. Compson, Tim Kopotsha, Michael Airey, Hanna Hailu, David Paul Humphreys, Oliver Zaccheo, Kaushik Sarkar, Mark Jairaj, Wild Gavin Barry, Andrew M. Ventom, Sarah L. Dugdale, Louis Christodoulou, Emma Dave, Sarah Malcolm, Diane Marshall, Alison Turner, Bruce Carrington, James T. Heads, Miren Zamacona, Sam Philip Heywood
Publikováno v:
mAbs
An antibody format, termed Fab-dsFv, has been designed for clinical indications that require monovalent target binding in the absence of direct Fc receptor (FcR) binding while retaining substantial serum presence. The variable fragment (Fv) domain of
Publikováno v:
BMSB
Broadcast and multicast represent a key opportunity in 5G for the massive consumption of multimedia services in the near future. These technologies permit to offload an important portion of this traffic in peak demand scenarios where users are consum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e60f805d07f1a2e63f446e4f170a6d5
https://zenodo.org/record/2531670
https://zenodo.org/record/2531670
Publikováno v:
BMSB
5G New Radio (NR) is the wireless standard that will become the foundation for the next generation of mobile networks. NR implements different techniques that improve the performance in terms of data rate, coverage, reliability, latency or mobility.
Autor:
Louis Christodoulou, Anna Lauren, Claudia Sievers, Michael Auer, Mary Birchler, Anna Fogdell-Hahn, Anders Sjödin, Malin Ryner, Poul Erik Jensen, Marc Pallardy, Roland S. Liblau, Marlies Jank, Finn Sellebjerg, Raija L.P. Lindberg, Florian Deisenhammer
Publikováno v:
Multiple sclerosis (Houndmills, Basingstoke, England). 25(3)
Background: Anti-drug antibodies (ADA) against natalizumab develop early during treatment. ADA persistency is defined by two consecutive positive results as performed by the current qualitative ELISA assay (positive/negative). Very little is known ab
The FcRn inhibitor rozanolixizumab reduces human serum IgG concentration: A randomized phase 1 study
Autor:
Peter Kiessling, Bryan Smith, Graham Price, Grant Langdon, Emma Jones, Frank R. Brennan, Muhammad Bari, Louis Christodoulou, Ian White, Diep Tran, Rocio Lledo-Garcia, Shikiko Watanabe, Stephen Jolles
Publikováno v:
Science translational medicine. 9(414)
Pathogenic immunoglobulin G (IgG) autoantibodies characterize some human autoimmune diseases; their high concentration and long half-life are dependent on recycling by the neonatal Fc receptor (FcRn). Inhibition of FcRn is an attractive new treatment
Autor:
Amanda S. Cross, Brendon MacKenzie, Louis Christodoulou, James T. Heads, Carl Brendan Doyle, Matthew Page, Hanna Hailu, Karine Jeannine Madeleine Hervé, Mark Ellis, Sarah L. Dugdale, Victoria O’Dowd, Nicola L. Davies, Alison Turner, Daniel John Lightwood, Adrian Moore, David Edward Ormonde Knight, Marco Kriek, Kaushik Sarkar, Mark Jairaj, David P. Humphreys, Matthew Cox, Kerry Louise Tyson, Joanne E. Compson, Amanda K. F. Oxbrow
Publikováno v:
Clinical and Vaccine Immunology. 20:377-390
Clostridium difficile infections are a major cause of antibiotic-associated diarrhea in hospital and care facility patients. In spite of the availability of effective antibiotic treatments, C. difficile infection (CDI) is still a major cause of patie