Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Louis Brogley"'
Autor:
David F. Nakamura, Hing L. Sham, John-Michael Sauer, Dean R. Artis, Lany Ruslim, Ted Yednock, Michael A. Pleiss, Gary Probst, Marc Adler, Minghua Sun, Louis Brogley, Michael S. Dappen, Roy K. Hom, Michel Maillard, Nanhua Yao, Simeon Bowers, Andrei W. Konradi, Jay S. Tung, Raymond A. Ng, Andrea Gailunas, Wes Zmolek, Kevin P. Quinn, Fang Lawrence Y, Varghese John, R. Jeffrey Neitz, Michael P. Bova
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:4674-4679
The structure activity relationship of the prime region of conformationally restricted hydroxyethylamine (HEA) BACE inhibitors is described. Variation of the P1′ region provided selectivity over Cat-D with a series of 2,2-dioxo-isothiochromanes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7bd8b1a206227969363800a4024a00c
https://doi.org/10.1016/j.bmcl.2013.06.006
https://doi.org/10.1016/j.bmcl.2013.06.006
Autor:
Gergley Tóth, Hu Pan, Gary Probst, John-Michael Sauer, Dean R. Artis, Anh P. Truong, Michael P. Bova, Wes Zmolek, Ted Yednock, Jose Aquino, Michael S. Dappen, Kevin P. Quinn, Sukanto Sinha, Varghese John, Hing L. Sham, Michael A. Pleiss, Roy K. Hom, Lany Ruslim, Louis Brogley, Jennifer Sealy, Nanhua Yao, Larry Fang, Jay S. Tung, John A. Tucker, Eric Brecht, Andrei W. Konradi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4789-4794
Herein we describe further evolution of hydroxyethylamine inhibitors of BACE-1 with enhanced permeability characteristics necessary for CNS penetration. Variation at the P2' position of the inhibitor with more polar substituents led to compounds 19 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5850a2826857f906d4175d1b9a311a
https://doi.org/10.1016/j.bmcl.2010.06.112
https://doi.org/10.1016/j.bmcl.2010.06.112
Autor:
Nanhua Yao, Hing L. Sham, Hu Pan, Zhao Ren, Ted Yednock, Simeon Bowers, Gergely Toth, Louis Brogley, Anh P. Truong, Jing Wu, Martin L. Neitzel, Kevin P. Quinn, Frederique Bard, John-Michael Sauer, Dean R. Artis, Jennifer Sealy, Larry Fang, Kyle Powell, Gary Probst, Irene Griswold-Prenner, R. Jeffrey Neitz, Andrei W. Konradi, Roy K. Hom
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(24)
From high throughput screening, we discovered compound 1, the prototype for a series of disubstituted thiophene inhibitors of JNK which is selective towards closely related MAP kinases p38 and Erk2. Herein we describe the evolution of these compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cba7852fb285f9d0c7004539c641ccd
https://pubmed.ncbi.nlm.nih.gov/21071223
https://pubmed.ncbi.nlm.nih.gov/21071223
Autor:
Joseph B. Moon, Donna J. Paddock, Louis Brogley, and Sukanto Sinha, Nancy Jewett, Timothy E. Benson, Michael S. Dappen, John A. Tucker, Thomas L. Emmons, Roy K. Hom, Michel Maillard, Alfredo G. Tomasselli, Thorsett Eugene D, Shumeye Mamo, D. Bryan Prince, Varghese John, D. Danielle Woods, Michael J. Bienkowski
Publikováno v:
Journal of medicinal chemistry. 50(4)
The design and synthesis of a novel series of potent and cell permeable peptidomimetic inhibitors of the human beta-secretase (BACE) are described. These inhibitors feature a hydroxyethyl secondary amine isostere and a novel aromatic ring replacement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52cd1c1f1ac700a20d12b3fb48c9bf8c
https://pubmed.ncbi.nlm.nih.gov/17300163
https://pubmed.ncbi.nlm.nih.gov/17300163
Autor:
Michel C. Maillard, Roy K. Hom, Timothy E. Benson, Joseph B. Moon, Shumeye Mamo, Michael Bienkowski, Alfredo G. Tomasselli, Danielle D. Woods, D. Bryan Prince, Donna J. Paddock, Thomas L. Emmons, John A. Tucker, Michael S. Dappen, Louis Brogley, Eugene D. Thorsett, Nancy Jewett, Sukanto Sinha, Varghese John
Publikováno v:
Journal of Medicinal Chemistry; Feb2007, Vol. 50 Issue 4, p776-781, 6p
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 935:109-114
Previous studies of N,N′-dicyclohexylcarbodiimide (DCCD)-modified bacteriorhodopsin (Kenthal, R. et al. (1985) Biochemistry 24, 4275–4279) used reaction conditions (detergent micelles) that are not optimal for subsequent physical studies. The pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696717c03daa353c4d09ecad40789a05
https://doi.org/10.1016/0005-2728(88)90207-1
https://doi.org/10.1016/0005-2728(88)90207-1