Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Louis Allott"'
Autor:
Stephen J. Archibald, Louis Allott
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 6, Iss 1, Pp 1-28 (2021)
Abstract The aluminium-[18F]fluoride ([18F]AlF) radiolabelling method combines the favourable decay characteristics of fluorine-18 with the convenience and familiarity of metal-based radiochemistry and has been used to parallel gallium-68 radiopharma
Externí odkaz:
https://doaj.org/article/4e5f06acee8545c78faf7d07f37f6c28
Autor:
Stephen J. Archibald, Louis Allott
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 6, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/b0d64b6783d345799242dc8a8b2820c7
Autor:
Louis Allott, Diana Brickute, Cen Chen, Marta Braga, Chris Barnes, Ning Wang, Eric O. Aboagye
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 5, Iss 1, Pp 1-17 (2020)
Abstract Background Glycogen is a multibranched polysaccharide of glucose produced by cells to store energy and plays a key role in cancer. A previously reported fluorescent probe (CDg4) was shown to selectively bind glycogen in mouse embryonic stem
Externí odkaz:
https://doaj.org/article/639eef8041cd4290b1ce5944d1549f8c
Autor:
Louis Allott, Cecilia Miranda, Angela Hayes, Florence Raynaud, Christopher Cawthorne, Graham Smith
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 4, Iss 1, Pp 1-20 (2019)
Abstract Background The histological evaluation of estrogen receptor (ER) and progesterone receptor (PR) expression in breast cancer lesions from biopsy tissue can stratify patients to receive endocrine therapy. Furthermore, PR expression can predict
Externí odkaz:
https://doaj.org/article/3f47645b00fc45078c3720bc99d62dec
Autor:
Yunqing Li, Marianna Inglese, Suraiya Dubash, Chris Barnes, Diana Brickute, Marta Costa Braga, Ning Wang, Alice Beckley, Kathrin Heinzmann, Louis Allott, Haonan Lu, Cen Chen, Ruisi Fu, Laurence Carroll, Eric O. Aboagye
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1246 (2021)
Hypoxia is a complex microenvironmental condition known to regulate choline kinase α (CHKA) activity and choline transport through transcription factor hypoxia-inducible factor-1α (HIF-1α) and, therefore, may confound the uptake of choline radiotr
Externí odkaz:
https://doaj.org/article/d45310b8a4984fdbbf4cf37c689fdb94
Autor:
Vessela Vassileva, Marta Braga, Chris Barnes, Justyna Przystal, Ali Ashek, Louis Allott, Diana Brickute, Joel Abrahams, Keittisak Suwan, Angel M. Carcaboso, Amin Hajitou, Eric O. Aboagye
Publikováno v:
Biomedicines, Vol 9, Iss 7, p 811 (2021)
Background: Reprogrammed cellular metabolism is a cancer hallmark. In addition to increased glycolysis, the oxidation of acetate in the citric acid cycle is another common metabolic phenotype. We have recently developed a novel fluorine-18-labelled t
Externí odkaz:
https://doaj.org/article/827fd890bd0147e8ae477a6ac547696d
Autor:
Ning Wang, Diana Brickute, Marta Braga, Chris Barnes, Haonan Lu, Louis Allott, Eric O. Aboagye
Publikováno v:
Pharmaceutics, Vol 13, Iss 7, p 1078 (2021)
Choline kinase alpha (CHKA) is a promising target for the development of cancer therapeutics. We have previously reported ICL-CCIC-0019, a potent CHKA inhibitor with high cellular activity but with some unfavorable pharmacological properties. In this
Externí odkaz:
https://doaj.org/article/71e7397d4fe841c29cfd8b0878c1ad76
Publikováno v:
Molecular Imaging, Vol 14 (2015)
Steroid hormone receptor (SHR) expression and changes in SHR expression compared to basal levels, whether upregulated, down-regulated, or mutated, form a distinguishing feature of some breast, ovarian, and prostate cancers. These receptors act to ind
Externí odkaz:
https://doaj.org/article/a1abe55c2f0743a78cab6d065ba8083e
Autor:
Gabriela Kramer-Marek, Graham Smith, Wim J.G. Oyen, Kevin J. Harrington, Louis Allott, Daniela M. Ciobota, Rhodri Smith, Thomas A. Burley, Chiara Da Pieve, Carlos D. Martins
Representative 3D-rendering of segmented MCF-7, MDA-MB-468 and MDA-MB-231 xenografts following PET/CT image acquisition 3 h after 89Zr-DFO-ZHER3:8698 injection.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d18fd39f5aab8a016445ea75c5b6e5a
https://doi.org/10.1158/1078-0432.22464824
https://doi.org/10.1158/1078-0432.22464824
Autor:
Gabriela Kramer-Marek, Graham Smith, Wim J.G. Oyen, Kevin J. Harrington, Louis Allott, Daniela M. Ciobota, Rhodri Smith, Thomas A. Burley, Chiara Da Pieve, Carlos D. Martins
Purpose: Recent studies have highlighted a role of HER3 in HER2-driven cancers (e.g., breast cancer), implicating the upregulation of the receptor in resistance to HER-targeted therapies and Hsp90 inhibitors (e.g., AUY922). Therefore, we have develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319e1decfc82bee5d18d838c987f213f
https://doi.org/10.1158/1078-0432.c.6525815.v1
https://doi.org/10.1158/1078-0432.c.6525815.v1