Zobrazeno 1 - 10
of 338
pro vyhledávání: '"Louis A. Cohen"'
Autor:
Louis J. Cohen, Sun M. Han, Pearson Lau, Daniela Guisado, Yupu Liang, Toshiki G. Nakashige, Thamina Ali, David Chiang, Adeeb Rahman, Sean F. Brady
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Lectins are non-enzymatic carbohydrate binding proteins important to human cellular functions. Here, the authors characterize a lectin produced by a human associated bacterium, and show that interacts with myeloid cells in the blood and intestine, su
Externí odkaz:
https://doaj.org/article/1df5145a09fe429d8021a79dc2379add
Autor:
Laurie Keefer, Tina Siganporia, Louis J. Cohen, Laura Manning, Ryan C. Ungaro, Benjamin L Cohen, Anthony Biello, Marla Dubinsky, Stacy Tse, Ksenia Gorbenko
Publikováno v:
Clinical Gastroenterology and Hepatology. 20:1831-1838
Background and Aims Integrated IBD care is effective but not routinely implemented. Validated methods that simultaneously address mind and body targets such as resilience may improve access and outcomes. We describe the development and implementation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a8aa7ae5ca1266a0f2378a2dbbda65
https://doi.org/10.1016/j.cgh.2021.11.013
https://doi.org/10.1016/j.cgh.2021.11.013
Autor:
Andreia B. Estrela, Toshiki G. Nakashige, Christophe Lemetre, Ian D. Woodworth, Jazz L. Weisman, Louis J. Cohen, Sean F. Brady
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT The effect of the microbiota on its human host is driven, at least in part, by small-molecule and protein effectors it produces. Here, we report on the use of functional multigenomic screening to identify microbiota-encoded effectors. In thi
Externí odkaz:
https://doaj.org/article/c30310d16176471586d2970fd4e6b38e
Autor:
Kanami Sugimoto-Kawabata, Hiroshi Shimada, Kaoru Sakai, Kazuo Suzuki, Thomas Kelder, Elsbet J. Pieterman, Louis H. Cohen, Louis M. Havekes, Hans M. Princen, Anita M. van den Hoek
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 5, Pp 1255-1264 (2013)
Bile acid sequestrants (BASs) are cholesterol-lowering drugs that also affect hyperglycemia. The mechanism by which BASs exert these and other metabolic effects beyond cholesterol lowering remains poorly understood. The present study aimed to investi
Externí odkaz:
https://doaj.org/article/aef6254d56e24440b004893f7a2d5f51
Autor:
Louis J. Cohen, Sun M. Han, Pearson Lau, Daniela Guisado, Yupu Liang, Toshiki G. Nakashige, Thamina Ali, David Chiang, Adeeb Rahman, Sean F. Brady
Publikováno v:
Nature communications. 13(1)
The mechanisms by which commensal organisms affect human physiology remain poorly understood. Lectins are non-enzymatic carbohydrate binding proteins that all organisms employ as part of establishing a niche, evading host-defenses and protecting agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b2c4a5bc637d6446d6d4ad9c6b9aa5
https://pubmed.ncbi.nlm.nih.gov/35661736
https://pubmed.ncbi.nlm.nih.gov/35661736
Autor:
Jeremy Kaplitt, Paula Y. Calle, Louis J. Cohen, Rhiannon R. Aguilar, Amanda J. Pickard, Aneta Rogoz, Seong-Hwan Kim, Justin R. Cross, Xavier Vila-Farrés, Christophe Lemetre, J. Kipchirchir Bitok, Daria Esterházy, Craig P. Hunter, Emma A. Gordon, Sun M. Han, Sean F. Brady, Ana Emiliano, John Chu
Publikováno v:
Nature. 549:48-53
Commensal bacteria are believed to have important roles in human health. The mechanisms by which they affect mammalian physiology remain poorly understood, but bacterial metabolites are likely to be key components of host interactions. Here we use bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3a623e5a2561035885e91e83da8774d
https://doi.org/10.1038/nature23874
https://doi.org/10.1038/nature23874
Autor:
Louis J. Cohen, Sean F. Brady, Joel S. Freundlich, David S. Perlin, Henry Zebroski, Boojala Vijay B. Reddy, Wooyoung Cho, John Chu, Melinda A. Ternei, Xavier Vila-Farrés, Daigo Inoyama, Christophe Lemetre
Publikováno v:
Journal of the American Chemical Society. 139:1404-1407
Bacterial culture broth extracts have been the starting point for the development of numerous therapeutics. However, only a small fraction of bacterial biosynthetic diversity is accessible using this strategy. Here, we apply a discovery approach that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fbcc76a9ee302a2b1a4baf1a8513399
https://doi.org/10.1021/jacs.6b11861
https://doi.org/10.1021/jacs.6b11861
Autor:
Toshiki G. Nakashige, Louis J. Cohen, Sean F. Brady, Jazz L. Weisman, Ian D. Woodworth, Christophe Lemetre, Andreia B. Estrela
Publikováno v:
mBio, Vol 10, Iss 6, p e02587-19 (2019)
mBio, Vol 10, Iss 6 (2019)
mBio
mBio, Vol 10, Iss 6 (2019)
mBio
Human-associated bacteria are thought to encode bioactive small molecules and proteins that play an intimate role in human health and disease. Here, we report on the creation and functional screening of a multigenomic library constructed using genomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b19f703e2c85dba5513dada0f77ac4
https://doaj.org/article/fdb4f33b4d574bbf82a543f583741732
https://doaj.org/article/fdb4f33b4d574bbf82a543f583741732
Autor:
Alexander Greenstein, Marla Dubinsky, Zane Gallinger, Robert Hirten, Ryan C. Ungaro, Sudarshan Paramsothy, Maia Kayal, Jean-Frederic Colombel, Priti Poojary, Louis J. Cohen, Aparna Saha, Saurabh Mehandru, Judy H. Cho, Benjamin L. Cohen, Girish N. Nadkarni
Publikováno v:
International journal of colorectal disease. 34(10)
PURPOSE: Despite advances in biologic therapy, approximately 10–15% of ulcerative colitis (UC) patients require surgery. We aimed to (1) examine the rates of emergent colectomy and elective ileal pouch anal anastomosis (IPAA) over time among UC pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24c1bef36e4308011c4e7a4d418466a
https://pubmed.ncbi.nlm.nih.gov/31512019
https://pubmed.ncbi.nlm.nih.gov/31512019
Autor:
Amanda J. Pickard, Han Sm, Cross, Sean F. Brady, Louis J. Cohen, Arka Rao, Dominic A. Colosimo, Kohn Ja, Luo Pm
Despite evidence linking the human microbiome to health and disease, the mechanistic details of how the microbiota affects human physiology remain largely unknown. Metabolites encoded by bacteria are expected to play an integral role in the microbiot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd3f808d79b9562f21f1c12c814fa09
https://doi.org/10.1101/614537
https://doi.org/10.1101/614537
