Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Louis A. Clark"'
Autor:
Matthew Jarpe, You Li, John Eldredge, Herman W. T. van Vlijmen, P. Ann Boriack-Sjodin, Louis A. Clark, Eric S. Day, Miller Stephan S, Christopher Fitch, Kenneth Simon
Publikováno v:
Protein Engineering Design and Selection. 22:93-101
A design approach was taken to investigate the feasibility of replacing single complementarity determining region (CDR) antibody loops. This approach may complement simpler mutation-based strategies for rational antibody design by expanding conformat
Publikováno v:
Adsorption. 12:417-422
For anisotropic nanoporous materials, guest diffusion is often reflected by a diffusion tensor rather than a scalar diffusion coefficient. Moreover, the resulting diffusion anisotropy may notably differ for different guest molecules. As a particular
Publikováno v:
The Journal of Immunology. 177:333-340
Probable germline gene sequences from thousands of aligned mature Ab sequences are inferred using simple computational matching to known V(D)J genes. Comparison of the germline to mature sequences in a structural region-dependent fashion allows insig
Autor:
Stefano F. Liparoto, John Eldredge, You Li, Christopher Fitch, Mia Rushe, Alexey Lugovskoy, Karl J. M. Hanf, Matthew Jarpe, Herman W. T. van Vlijmen, Woody Sherman, Kenneth Simon, Louis A. Clark, P. Ann Boriack-Sjodin, Miller Stephan S, Bethany Friedman
Publikováno v:
Protein Science. 15:949-960
Improving the affinity of a high-affinity protein-protein interaction is a challenging problem that has practical applications in the development of therapeutic biomolecules. We used a combination of structure-based computational methods to optimize
Publikováno v:
Protein Science. 14:993-1003
We simulate the aggregation thermodynamics and kinetics of proteins L and G, each of which self-assembles to the same alpha/beta [corrected] topology through distinct folding mechanisms. We find that the aggregation kinetics of both proteins at an ex
Publikováno v:
Journal of the American Chemical Society. 126:936-947
The most commonly cited example of a transition state shape selective reaction, m-xylene disproportionation in zeolites, is examined to determine if the local spatial environment of a reaction can significantly alter selectivity. In the studied react
Publikováno v:
Molecular Simulation. 29:29-46
This paper discusses the application of object-oriented programming (OOP) design concepts to the development of molecular simulation code. A number of new languages such as Fortran 90 (F90) have been developed over the last decade that support the OO
Publikováno v:
The Journal of Physical Chemistry B. 106:3882-3889
Ammonia TPD experiments have been carried out on protonated forms of the zeolites FAU, FER, MFI, and MOR to investigate the acid strength dependence on OH group location and Al content. Effective adsorption energy distributions are derived using a re
Autor:
Louis A. Clark
This chapter begins with an overview of the synergy between rational design and screening or selection. The choice of a rational design approach requires consideration of the number of enzyme variants that can be evaluated experimentally. A review of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4af101b962006c1aef95d3e6d487ee46
https://doi.org/10.1128/9781555816827.ch31
https://doi.org/10.1128/9781555816827.ch31
Publikováno v:
The Journal of Physical Chemistry B. 105:4698-4708
19F and 129Xe nuclear magnetic resonance spectroscopy (NMR) investigations were performed to validate predictions from Monte Carlo simulations for molecular siting in mordenite zeolites. For single-component adsorption, CF4 adsorbs preferentially in