Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Louis A, Carpino"'
Autor:
René Röder, Hardy Weißhoff, Clemens Mügge, Ulrich S. Schubert, Louis A. Carpino, Peter Henklein, Petra Henklein, Michael Pätzel
Publikováno v:
Journal of Peptide Science. 16:65-70
To prevent aspartimide formation and related side products in Asp-Xaa, particularly Asp-Gly-containing peptides, usually the 2-hydroxy-4-methoxybenzyl (Hmb) backbone amide protection is applied for peptide synthesis according to the Fmoc-protocols. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2169d0d18cb6bf2ed4f7cda85cd86eb
https://doi.org/10.1002/psc.1196
https://doi.org/10.1002/psc.1196
Autor:
Eberhard Krause, Adel Ali Abdel-Maksoud, Holger Wenschuh, Ayman El-Faham, Michael Beyermann, Michael Bienert, Peter Henklein, Louis A. Carpino, Dumitru Ionescu, Khaled Nasr
Publikováno v:
Organic letters, 11(16): 3718–3721
The N-dicyclopropylmethyl (Dcpm) residue, introduced into amino acids via reaction of dicyclopropylmethanimine hydrochloride with an amino acid ester followed by sodium cyanoborohydride or triacetoxyborohydride reduction, can be used as an amide bond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a3c9fbd57db3d023d031eba735c8e1
https://doi.org/10.1021/ol901310q
https://doi.org/10.1021/ol901310q
Autor:
E.-S. M. E. Mansour, Louis A. Carpino, Mohamed A. Zewail, Adel Ali Abdel-Maksoud, Dumitru Ionescu
Publikováno v:
The Journal of Organic Chemistry. 72:1729-1736
Of the three theoretically possible, Bsmoc-related, naphthothiophene sulfone-based amino-protecting groups, the two most readily available derivatives, the alpha- and beta-Nsmoc analogues, have been examined as substitutes for the Bsmoc residue in ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1571c57c46ff4bc4110ccee936898d87
https://doi.org/10.1021/jo062397g
https://doi.org/10.1021/jo062397g
Autor:
Louis A. Carpino, Calin Dan Sferdean, Irene Coin, Michael Beyermann, Michael Bienert, Eberhard Krause, Rudolf Dolling
Publikováno v:
The Journal of Organic Chemistry. 71:6171-6177
The depsipeptide technique is a recently developed method for peptide synthesis which is applicable to difficult sequences when the synthetic difficulty arises because of aggregation phenomena. In the present work, application of the depsipeptide met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e06905fcdca9565d81582b98441d7e
https://doi.org/10.1021/jo060914p
https://doi.org/10.1021/jo060914p
Publikováno v:
Tetrahedron Letters. 46:1361-1364
N→O acyl migrations at serine or threonine residues in peptides or proteins have previously been observed upon treatment with strong acids. Here we show that the extent of such N→O shifts depends on the peptide sequence and even in the presence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2835dac4246fafc91921e5d65312d767
https://doi.org/10.1016/j.tetlet.2004.12.089
https://doi.org/10.1016/j.tetlet.2004.12.089
Autor:
Louis A. Carpino, Michael Schümann, Eberhard Krause, Calin Dan Sferdean, Heinz Fabian, Michael Beyermann, Michael Bienert
Publikováno v:
Tetrahedron Letters. 45:7519-7523
Recently a 26-mer peptide 1 incorporating Ser and Thr was described as a ‘difficult’ sequence that could not be synthesized by standard methods. If the first Ser residue was used to incorporate a depsipeptide unit, the resulting hybrid was readil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e08f8392fbb67ed452141923e2757724
https://doi.org/10.1016/j.tetlet.2004.07.162
https://doi.org/10.1016/j.tetlet.2004.07.162
Publikováno v:
The Journal of Organic Chemistry. 69:62-71
Organophosphorus esters 9, 10, 14, and 15 prepared via reaction of diethyl- and diphenylphosphoryl chloride, di(o-tolyl)phosphinyl chloride, and 2,8-dimethylphenoxaphosphinyl chloride with HOAt are excellent coupling reagents for peptide synthesis wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a2fe16d6046886251eb6c66dc2445ab
https://doi.org/10.1021/jo0300183
https://doi.org/10.1021/jo0300183
Autor:
Mohamed Ismail, George A. Truran, Louis A. Carpino, Gary A. Siwruk, Morgan Barry A, Shahnaz Ghassemi, Dumitru Ionescu, Elsayed Mansour, Dean Sadat-Aalaee, and John S. Eynon
Publikováno v:
Organic Process Research & Development. 7:28-37
The Fmoc/TAEA and Bsmoc/TAEA methods for the rapid, continuous solution synthesis of peptide segments are shown to be applicable to the gram-scale synthesis of short peptides as well as, for the first time, to the synthesis of a relatively long (22-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f3729650052419580b5f06a6ac1d01a
https://doi.org/10.1021/op0202179
https://doi.org/10.1021/op0202179
Autor:
Louis A. Carpino, Michael Philbin
Publikováno v:
The Journal of Organic Chemistry. 64:4315-4323
A new type of amino-protecting group is described in which a Michael acceptor is incorporated into the protectant so that treatment with a nucleophile will trigger deblocking. Comparison of various Michael acceptors showed that for several key electr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3044b173f7d2a4e93ada6f1dee98ee59
https://doi.org/10.1021/jo982141d
https://doi.org/10.1021/jo982141d
Autor:
Ralf Warrass, George A. Truran, Dumitru Ionescu, Shin Iguchi, Louis A. Carpino, Mohamed Ismail, Ayman El-Faham, Christoph Riemer, Elsayed Mansour
Publikováno v:
The Journal of Organic Chemistry. 64:4324-4338
Full details are presented for use of the Bsmoc amino-protecting group for both solid phase and rapid continuous solution syntheses. Application to the latter methodology represents a significant improvement over the corresponding Fmoc-based method f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd3c02188da69e85e14a741d75d624e7
https://doi.org/10.1021/jo982140l
https://doi.org/10.1021/jo982140l