Zobrazeno 1 - 10
of 415
pro vyhledávání: '"Louis Maes"'
Autor:
Brian W. Slafer, Marco A. Dessoy, Ramon G. de Oliveira, Maria C. Mollo, Eun Lee, An Matheeussen, Louis Maes, Guy Caljon, Leonardo L. G. Ferreira, Renata Krogh, Adriano D. Andricopulo, Luiza R. Cruz, Charles E. Mowbray, Jadel M. Kratz, Luiz C. Dias
Publikováno v:
ACS Omega, Vol 9, Iss 20, Pp 22360-22370 (2024)
Externí odkaz:
https://doaj.org/article/181f8460774544aa8d922443939c65c7
Autor:
Laura Dirkx, Sara I Van Acker, Yasmine Nicolaes, João Luís Reis Cunha, Rokaya Ahmad, Rik Hendrickx, Ben Caljon, Hideo Imamura, Didier G Ebo, Daniel C Jeffares, Yann G-J Sterckx, Louis Maes, Sarah Hendrickx, Guy Caljon
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1012181 (2024)
Addressing the challenges of quiescence and post-treatment relapse is of utmost importance in the microbiology field. This study shows that Leishmania infantum and L. donovani parasites rapidly enter into quiescence after an estimated 2-3 divisions i
Externí odkaz:
https://doaj.org/article/c3328a026fb045d3b54dc41a434fc149
Autor:
Thibault Gendron, Don Antoine Lanfranchi, Nicole I. Wenzel, Hripsimée Kessedjian, Beate Jannack, Louis Maes, Sandrine Cojean, Thomas J. J. Müller, Philippe M. Loiseau, Elisabeth Davioud-Charvet
Publikováno v:
Molecules, Vol 29, Iss 7, p 1620 (2024)
2,6-Diaryl-4H-tetrahydro-thiopyran-4-ones and corresponding sulfoxide and sulfone derivatives were designed to lower the major toxicity of their parent anti-kinetoplatidal diarylideneacetones through a prodrug effect. Novel diastereoselective methodo
Externí odkaz:
https://doaj.org/article/65239637fac74e389deee1c922309e2e
Autor:
Dorien Mabille, Laura Dirkx, Sofie Thys, Marjorie Vermeersch, Daniel Montenye, Matthias Govaerts, Sarah Hendrickx, Peter Takac, Johan Van Weyenbergh, Isabel Pintelon, Peter Delputte, Louis Maes, David Pérez-Morga, Jean-Pierre Timmermans, Guy Caljon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
A number of human African trypanosomiasis, or sleeping sickness, patients suffer from respiratory symptoms commonly attributed to cardiac insufficiency. Here, the authors characterise the role of pulmonary Trypanosoma brucei in respiratory infection.
Externí odkaz:
https://doaj.org/article/e94ea4949fe04471983657287813b459
Autor:
Yang Zheng, Joachim Müller, Stefan Kunz, Marco Siderius, Louis Maes, Guy Caljon, Norbert Müller, Andrew Hemphill, Geert Jan Sterk, Rob Leurs
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 19, Iss , Pp 47-55 (2022)
As there is a continuous need for novel anti-infectives, the present study aimed to fuse two modes of action into a novel 3-nitroimidazo[1,2-b]pyridazine scaffold to improve antiparasitic efficacy. For this purpose, we combined known structural eleme
Externí odkaz:
https://doaj.org/article/71ceaef05ad240feb9f42da5d282b02b
Autor:
Dorien Mabille, Kayhan Ilbeigi, Sarah Hendrickx, Marzuq A. Ungogo, Fabian Hulpia, Cai Lin, Louis Maes, Harry P. de Koning, Serge Van Calenbergh, Guy Caljon
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 19, Iss , Pp 21-30 (2022)
Animal trypanosomiasis (AT) is a parasitic disease with high socio-economic impact. Given the limited therapeutic options and problems of toxicity and drug resistance, this study assessed redirecting our previously identified antitrypanosomal nucleos
Externí odkaz:
https://doaj.org/article/67220a1220024591ad64ccc816d06c7e
Autor:
Laura Dirkx, Sarah Hendrickx, Margot Merlot, Dimitri Bulté, Marick Starick, Jessy Elst, André Bafica, Didier G. Ebo, Louis Maes, Johan Van Weyenbergh, Guy Caljon
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Long-term hematopoietic stem cells may act as protective niches for the Leishmania parasite, potentially contributing to treatment failure in cases of visceral leishmaniasis.
Externí odkaz:
https://doaj.org/article/06e987ab8f3e420fb34f79a37fb2e9dd
Autor:
Cai Lin, Fabian Hulpia, Izet Karalic, Laurens De Schepper, Louis Maes, Guy Caljon, Serge Van Calenbergh
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss , Pp 57-66 (2021)
Kinetoplastid parasites are the causative agents of Chagas disease (CD), leishmaniasis and human African trypanosomiasis (HAT). Despite a sustained decrease in the number of HAT cases, more efforts are needed to discover safe and effective therapies
Externí odkaz:
https://doaj.org/article/a482b44f49a740799353ff42d4fea40a
Autor:
Dr. Daniel G. Silva, Pim‐Bart Feijens, Rik Hendrickx, An Matheeussen, Lucie Grey, Prof. Dr. Guy Caljon, Prof. Dr. Louis Maes, Prof. Dr. Flavio S. Emery, Dr. Anna Junker
Publikováno v:
ChemistryOpen, Vol 10, Iss 9, Pp 922-927 (2021)
Abstract This study identified the isoindolone ring as a scaffold for novel agents against Trypanosoma brucei rhodesiense and explored the structure‐activity relationships of various aromatic ring substitutions. The compounds were evaluated in an i
Externí odkaz:
https://doaj.org/article/6454a6ea286a48ecbeea63e1c4977c06
Publikováno v:
Molecules, Vol 28, Iss 13, p 4939 (2023)
Malaria continues to pose a significant health threat, causing thousands of deaths each year. The limited availability of vaccines and medications, combined with the emergence of drug resistance, further complicates the fight against this disease. In
Externí odkaz:
https://doaj.org/article/affb4457868d42f1a3c374913a0413f2