Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Louie Z. Cai"'
1
Data from BAP1 Loss Is Associated with DNA Methylomic Repatterning in Highly Aggressive Class 2 Uveal Melanomas
Autor: J. William Harbour, Stefan Kurtenbach, Christina L. Decatur, Karam A. Alawa, Louie Z. Cai, Parker L. Bussies, Jeffim N. Kuznetsov, Matthew G. Field
Purpose:The strong association between BAP1 mutations and metastasizing Class 2 uveal melanoma (UM) suggests that epigenetic alterations may play a significant role in tumor progression. Thus, we characterized the impact of BAP1 loss on the DNA methy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133dc3d6549bc8eb17c38f7345ba1ba8
https://doi.org/10.1158/1078-0432.c.6528020
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2
Supplementary Table S4 from BAP1 Loss Is Associated with DNA Methylomic Repatterning in Highly Aggressive Class 2 Uveal Melanomas
Autor: J. William Harbour, Stefan Kurtenbach, Christina L. Decatur, Karam A. Alawa, Louie Z. Cai, Parker L. Bussies, Jeffim N. Kuznetsov, Matthew G. Field
HyperMethvsDecGE_ChrLoc: Chromosomal loci enriched (FDR < 0.05) for hypermethylated/downregulated genes in Class 2 uveal melanomas compared to Class 1 uveal melanomas HypoMethvsIncGE_ChrLoc: Chromosomal loci enriched (FDR < 0.05) for hypomethylated/u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ff9c25d1c0f0f7711ed40f6b2e1878
https://doi.org/10.1158/1078-0432.22471814.v1
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3
Supplementary Table S6 from BAP1 Loss Is Associated with DNA Methylomic Repatterning in Highly Aggressive Class 2 Uveal Melanomas
Autor: J. William Harbour, Stefan Kurtenbach, Christina L. Decatur, Karam A. Alawa, Louie Z. Cai, Parker L. Bussies, Jeffim N. Kuznetsov, Matthew G. Field
BAP1KDvsWT_HyperMethDecGE: All significantly hypermethylated probes from hypermethylated/downregulated genes (p < 0.05) with an absolute value (log2(RNA fold change)) > 1 and absolute value (methylation Delta Beta value) > 0.01 in BAP1KDvsWT 92.1 and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36db8690e6f2ee0668060c0e83f83b8f
https://doi.org/10.1158/1078-0432.22471808.v1
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4
Supplementary Table S3 from BAP1 Loss Is Associated with DNA Methylomic Repatterning in Highly Aggressive Class 2 Uveal Melanomas
Autor: J. William Harbour, Stefan Kurtenbach, Christina L. Decatur, Karam A. Alawa, Louie Z. Cai, Parker L. Bussies, Jeffim N. Kuznetsov, Matthew G. Field
HyperMethvsDecGE_Cutoffs: All significantly hypermethylated probes from hypermethylated/downregulated genes (FDR < 0.05) with an absolute value (log2(RNA fold change)) > 1 and absolute value (methylation Delta Beta value) > 0.05 in Class 2 uveal mela
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08bd5c0a9415b19510fbb6760d1ef14a
https://doi.org/10.1158/1078-0432.22471817
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5
Supplementary Table S2 from BAP1 Loss Is Associated with DNA Methylomic Repatterning in Highly Aggressive Class 2 Uveal Melanomas
Autor: J. William Harbour, Stefan Kurtenbach, Christina L. Decatur, Karam A. Alawa, Louie Z. Cai, Parker L. Bussies, Jeffim N. Kuznetsov, Matthew G. Field
TCGA_Methyl_DMP: All significantly methylated probes (FDR < 0.05) in Class 2 uveal melanomas compared to Class 1 uveal melanomas from the 80 TCGA cases. JWH_Methyl_DMP: All significantly methylated probes (p < 0.05) in Class 2 uveal melanomas compare
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857f7984ad063e406f03e29813db175d
https://doi.org/10.1158/1078-0432.22471820
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6
Supplementary Figure S1 from BAP1 Loss Is Associated with DNA Methylomic Repatterning in Highly Aggressive Class 2 Uveal Melanomas
Autor: J. William Harbour, Stefan Kurtenbach, Christina L. Decatur, Karam A. Alawa, Louie Z. Cai, Parker L. Bussies, Jeffim N. Kuznetsov, Matthew G. Field
BAP1 knockdown alters the epigenomic profile in uveal melanoma (UM) cells. (A) Western blot of tetracycline-inducible 92.1 and Mel202 shBAP1 UM cells without (-) and with (+) induction by doxycycline. (B) Multidimensional scaling (MDS) plot of the 10
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79644012603e94214dcdcb80198a231a
https://doi.org/10.1158/1078-0432.22471826
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8
Supplementary Table S5 from BAP1 Loss Is Associated with DNA Methylomic Repatterning in Highly Aggressive Class 2 Uveal Melanomas
Autor: J. William Harbour, Stefan Kurtenbach, Christina L. Decatur, Karam A. Alawa, Louie Z. Cai, Parker L. Bussies, Jeffim N. Kuznetsov, Matthew G. Field
BAP1KDvsWT_HyperMethyl: All significantly hypermethylated probes (FDR < 0.05) with an absolute value (log2(RNA fold change)) > 1 and absolute value (methylation Delta Beta value) > 0.01 in BAP1KDvsWT 92.1 and Mel202 cells. BAP1KDvsWT_HypoMethyl: All
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052dd9fba347f71dcd3250a0bceb7ade
https://doi.org/10.1158/1078-0432.22471811.v1
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9
BAP1 Loss Is Associated with DNA Methylomic Repatterning in Highly Aggressive Class 2 Uveal Melanomas
Autor: Louie Z. Cai, Stefan Kurtenbach, Jeffim N. Kuznetsov, Christina L. Decatur, Karam A. Alawa, Parker Bussies, Matthew G. Field, J. William Harbour
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 25(18)
PURPOSE: The strong association between BAP1 mutations and metastasizing Class 2 uveal melanoma (UM) suggests that epigenetic alterations may play a significant role in tumor progression. Thus, we characterized the impact of BAP1 loss on the DNA meth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a720d7e0264d70cf5f44eb3b822703
https://pubmed.ncbi.nlm.nih.gov/31285370
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