Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Louie Slocombe"'
Autor:
Louie Slocombe, Sara Imari Walker
Publikováno v:
ACS Central Science, Vol 10, Iss 5, Pp 949-952 (2024)
Externí odkaz:
https://doaj.org/article/3c559e80b9a04d65a2365431c36aaab4
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Proton transfer across hydrogen bonds in DNA can produce non-canonical nucleobase dimers and is a possible source of single-point mutations when these forms mismatch under replication. Previous computational studies have revealed this proces
Externí odkaz:
https://doaj.org/article/6cadea727e8f4f9188cef0814e5bd4d4
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-9 (2022)
Proton transfer between DNA bases can lead to mutagenic tautomers, but as their lifetimes are thought to be much shorter than DNA separation times their role during the DNA replication cycle is often overlooked. Here, the authors model the separation
Externí odkaz:
https://doaj.org/article/59bf2cf867874d9fb6072b9144f94e72
Publikováno v:
Communications Physics, Vol 5, Iss 1, Pp 1-9 (2022)
The genetic stability of DNA suffers from proton transfer along the hydrogen bonds that can lead to tautomerisation, creating mutations. The authors theoretically examine the tautomerisation of the GuanineCytosine (G-C) nucleotide base-pair using an
Externí odkaz:
https://doaj.org/article/5847c4bf8296465c99f8bc2434678987
Autor:
Youngchan Kim, Federico Bertagna, Edeline M. D’Souza, Derren J. Heyes, Linus O. Johannissen, Eveliny T. Nery, Antonio Pantelias, Alejandro Sanchez-Pedreño Jimenez, Louie Slocombe, Michael G. Spencer, Jim Al-Khalili, Gregory S. Engel, Sam Hay, Suzanne M. Hingley-Wilson, Kamalan Jeevaratnam, Alex R. Jones, Daniel R. Kattnig, Rebecca Lewis, Marco Sacchi, Nigel S. Scrutton, S. Ravi P. Silva, Johnjoe McFadden
Publikováno v:
Quantum Reports, Vol 3, Iss 1, Pp 80-126 (2021)
Understanding the rules of life is one of the most important scientific endeavours and has revolutionised both biology and biotechnology. Remarkable advances in observation techniques allow us to investigate a broad range of complex and dynamic biolo
Externí odkaz:
https://doaj.org/article/c9a53bf8f9df40dfb0a9e770fea02dbf
Publikováno v:
RSC Advances. 13:13384-13396
Hachimoji DNA is a synthetic nucleic acid extension of DNA formed by an additional four bases that can encode information. We examine the possibility of proton transfer between the hachimoji bases, which can result in base mismatch under replication.
Publikováno v:
The Journal of Physical Chemistry Letters. 14:9-15
The misincorporation of a noncomplementary DNA base in the polymerase active site is a critical source of replication errors that can lead to genetic mutations. In this work, we model the mechanism of wobble mispairing and the subsequent rate of misi
The adenine-thymine tautomer (A*-T*) has previously been discounted as a spontaneous mutagenesis mechanism due to the energetic instability of the tautomeric configuration. We study the stability of A*-T* while the nucleobases undergo DNA strand sepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98c1d7c6a488621152fbbfd1877b393
https://doi.org/10.26434/chemrxiv-2022-lzzsp
https://doi.org/10.26434/chemrxiv-2022-lzzsp
Publikováno v:
Physical Chemistry Chemical Physics. 23:4141-4150
Proton transfer along the hydrogen bonds of DNA can lead to the creation of short-lived, but biologically relevant point mutations that can further lead to gene mutation and, potentially, cancer. In this work, the energy landscape of the canonical A-
Autor:
Daniel R. Kattnig, Louie Slocombe, Nigel S. Scrutton, Eveliny T. Nery, Johnjoe McFadden, Edeline M. D’Souza, Youngchan Kim, Rebecca Lewis, Michael G. Spencer, Alejandro Sanchez-Pedreño Jimenez, Sam Hay, Federico Bertagna, Antonio Pantelias, S. Ravi P. Silva, Suzanne M. Hingley-Wilson, Marco Sacchi, Derren J. Heyes, Linus O. Johannissen, Jim Al-Khalili, Gregory S. Engel, Alex R. Jones, Kamalan Jeevaratnam
Publikováno v:
Quantum Reports, Vol 3, Iss 6, Pp 80-126 (2021)
Kim, Y, Bertagna, F, D’Souza, E M, Heyes, D J, Johannissen, L O, Nery, E T, Pantelias, A, SanchezPedreno, A, Slocombe, L, Spencer, M G, Al-Khalili, J, Engel, G S, Hay, S, Hingley-Wilson, S M, Jeevaratnam, K, Jones, A, Kattnig, D, Lewis, R, Sacchi, M, Scrutton, N, Silva, S R P & McFadden, J 2021, ' Quantum Biology: An Update and Perspective ', Quantum Reports, vol. 3, no. 1, pp. 80-126 . https://doi.org/10.3390/quantum3010006
Kim, Y, Bertagna, F, D’Souza, E M, Heyes, D J, Johannissen, L O, Nery, E T, Pantelias, A, SanchezPedreno, A, Slocombe, L, Spencer, M G, Al-Khalili, J, Engel, G S, Hay, S, Hingley-Wilson, S M, Jeevaratnam, K, Jones, A, Kattnig, D, Lewis, R, Sacchi, M, Scrutton, N, Silva, S R P & McFadden, J 2021, ' Quantum Biology: An Update and Perspective ', Quantum Reports, vol. 3, no. 1, pp. 80-126 . https://doi.org/10.3390/quantum3010006
Understanding the rules of life is one of the most important scientific endeavours and has revolutionised both biology and biotechnology. Remarkable advances in observation techniques allow us to investigate a broad range of complex and dynamic biolo