Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Louie Naumovski"'
Autor:
John H Strickler, Antonio Cubillo, Jin-Tung Liang, Marc Matrana, Mark Kozloff, Thomas Lowe, Martha Blaney, Mohammad Sahtout, Louie Naumovski, Zev A Wainberg
Publikováno v:
Future Oncology. 18:3011-3020
Aim: This phase II study investigated safety and efficacy of dilpacimab or bevacizumab plus FOLFIRI in patients with previously treated metastatic colorectal cancer (mCRC). Materials & methods: Overall, 66 patients were treated (n = 34 dilpacimab + F
Autor:
Ramesh K. Ramanathan, Louie Naumovski, Daniel Afar, Edward Reilly, Lan Wang, Huibin Yue, Shekman Wong, Monica Motwani, Peter Ansell, Chia-Chi Lin, Chia Jui Yen, Yoon-Koo Kang, Ravi Salgia, Patricia LoRusso, John H. Strickler
Progression-free survival in MET-amplified patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145067315457d206ba429757f27f4a59
https://doi.org/10.1158/1535-7163.22518675.v1
https://doi.org/10.1158/1535-7163.22518675.v1
Autor:
Ramesh K. Ramanathan, Louie Naumovski, Daniel Afar, Edward Reilly, Lan Wang, Huibin Yue, Shekman Wong, Monica Motwani, Peter Ansell, Chia-Chi Lin, Chia Jui Yen, Yoon-Koo Kang, Ravi Salgia, Patricia LoRusso, John H. Strickler
This first-in-human phase I study evaluated the pharmacokinetics, safety, and preliminary efficacy of telisotuzumab, formerly called ABT-700, an antagonistic antibody directed against c-Met. For dose escalation (3+3 design), 3 to 6 patients with adva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6640b77d2b8eba127728d9cdd567b7c4
https://doi.org/10.1158/1535-7163.c.6542055.v1
https://doi.org/10.1158/1535-7163.c.6542055.v1
Autor:
Ramesh K. Ramanathan, Louie Naumovski, Daniel Afar, Edward Reilly, Lan Wang, Huibin Yue, Shekman Wong, Monica Motwani, Peter Ansell, Chia-Chi Lin, Chia Jui Yen, Yoon-Koo Kang, Ravi Salgia, Patricia LoRusso, John H. Strickler
Additional details for MET-amplified patients with one or more postbaseline tumor assessment (n=9).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724d29e98782b3d44b4991678c167d4f
https://doi.org/10.1158/1535-7163.22518666
https://doi.org/10.1158/1535-7163.22518666
Autor:
Susan E. Morgan-Lappe, Jijie Gu, Louie Naumovski, Sherry L. Ralston, Wenqing Gao, Surekha S. Akella, Catherine Zhang, Sarah R. Mudd, Fang Jiang, Sanjay C. Panchal, Enrico L. DiGiammarino, Lucia J. Eaton, Kelly D. Foster-Duke, Deanna L. Haasch, Dominic J. Ambrosi, Jonathan A. Hickson, Yingchun Li
Table S1: ABT-165 binding affinity; Table S2: ABT-165 in vitro potency; Table S3: Effect of VEGF on anti-DLL4 cellular potency of ABT-165; Table S4: Summary of in vivo efficacy; Table S5: Key safety findings of ABT-487 and ABT-165; Figure S1: Serum c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948fdfba3f05b8a422e19034176fe36d
https://doi.org/10.1158/1535-7163.22505686
https://doi.org/10.1158/1535-7163.22505686
Autor:
Susan E. Morgan-Lappe, Jijie Gu, Louie Naumovski, Sherry L. Ralston, Wenqing Gao, Surekha S. Akella, Catherine Zhang, Sarah R. Mudd, Fang Jiang, Sanjay C. Panchal, Enrico L. DiGiammarino, Lucia J. Eaton, Kelly D. Foster-Duke, Deanna L. Haasch, Dominic J. Ambrosi, Jonathan A. Hickson, Yingchun Li
This file describes the binding assay details of surface plasmon resonance technology, ligand and receptor binding competition assays, western blot detection of DLL4 protein down-regulation, and the methods to measure total circulating soluble DLL4 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267ca9367d459176dea46bdd55158c64
https://doi.org/10.1158/1535-7163.22505689.v1
https://doi.org/10.1158/1535-7163.22505689.v1
Autor:
Susan E. Morgan-Lappe, Jijie Gu, Louie Naumovski, Sherry L. Ralston, Wenqing Gao, Surekha S. Akella, Catherine Zhang, Sarah R. Mudd, Fang Jiang, Sanjay C. Panchal, Enrico L. DiGiammarino, Lucia J. Eaton, Kelly D. Foster-Duke, Deanna L. Haasch, Dominic J. Ambrosi, Jonathan A. Hickson, Yingchun Li
Antiangiogenic therapy is a clinically validated modality in cancer treatment. To date, all approved antiangiogenic drugs primarily inhibit the VEGF pathway. Delta-like ligand 4 (DLL4) has been identified as a potential drug target in VEGF-independen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2454e519448df5024c51607be68974ce
https://doi.org/10.1158/1535-7163.c.6538150.v1
https://doi.org/10.1158/1535-7163.c.6538150.v1
Autor:
Victor M. Villalobos, Anthony Tolcher, James P. Allison, Padmanee Sharma, Randy Robinson, James W. Purcell, Akshanth R. Polepally, Huibin Yue, Dominic W. Lai, Hua Fang, Chris Chen, Louie Naumovski, Vivek Subbiah, Alexander I. Spira, John D. Powderly, Antoine Hollebecque, Jason J. Luke, George D. Demetri
Supplementary Table S2 shows LRRC15 IHC expression in tumor and stroma of patients with sarcoma treated ABBV-085 monotherapy at 3.6 or 4.2 mg/kg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2759a945219be6472c0fcb49ad3fe7
https://doi.org/10.1158/1078-0432.22479056.v1
https://doi.org/10.1158/1078-0432.22479056.v1
Autor:
Leo I. Gordon, Richard A. Miller, Jane N. Winter, Steven T. Rosen, Louie Naumovski, Jun Chen, Daina Variakojis, Elizabeth Hamilton, Sarah Miyata, Borko D. Jovanovic, Stewart Spies, David Patton, Irene B. Helenowski, William G. Spies, Andrew M. Evens
Purpose: Therapeutic strategies to enhance the efficacy of radioimmunotherapy have not been explored. Motexafin gadolinium is a novel anticancer agent that targets redox-dependent pathways and enhances sensitivity of tumor cells to ionizing radiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f54f59e963f38826f3289d0bd4b4225
https://doi.org/10.1158/1078-0432.c.6516849
https://doi.org/10.1158/1078-0432.c.6516849
Autor:
Victor M. Villalobos, Anthony Tolcher, James P. Allison, Padmanee Sharma, Randy Robinson, James W. Purcell, Akshanth R. Polepally, Huibin Yue, Dominic W. Lai, Hua Fang, Chris Chen, Louie Naumovski, Vivek Subbiah, Alexander I. Spira, John D. Powderly, Antoine Hollebecque, Jason J. Luke, George D. Demetri
Supplementary Figure S1 shows the study design.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f740555983e19b1c823b9f0c6228f7
https://doi.org/10.1158/1078-0432.22479068.v1
https://doi.org/10.1158/1078-0432.22479068.v1