Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Louie N. van de Lagemaat"'
Autor:
Keith Woodley, Laura S. Dillingh, George Giotopoulos, Pedro Madrigal, Kevin M. Rattigan, Céline Philippe, Vilma Dembitz, Aoife M. S. Magee, Ryan Asby, Louie N. van de Lagemaat, Christopher Mapperley, Sophie C. James, Jochen H. M. Prehn, Konstantinos Tzelepis, Kevin Rouault-Pierre, George S. Vassiliou, Kamil R. Kranc, G. Vignir Helgason, Brian J. P. Huntly, Paolo Gallipoli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Resistance to standard and novel therapies remains the main obstacle to cure in acute myeloid leukaemia (AML) and is often driven by metabolic adaptations which are therapeutically actionable. Here we identify inhibition of mannose-6-phospha
Externí odkaz:
https://doaj.org/article/a02c0de22e004847b729037f65f8b163
Autor:
Christine Young, John R. Russell, Louie N. Van De Lagemaat, Hannah Lawson, Christopher Mapperley, Kamil R. Kranc, Maria A. Christophorou
Publikováno v:
Biology Open, Vol 11, Iss 6 (2022)
Peptidylarginine deiminases (PADIs) are strongly associated with the development of autoimmunity, neurodegeneration and cancer but their physiological roles are ill-defined. The nuclear deiminase PADI4 regulates pluripotency in the mammalian pre-impl
Externí odkaz:
https://doaj.org/article/7fbdb19c2f9446879a86422a2d7d277d
Autor:
Azzurra Codino, Tomasz Turowski, Louie N. van de Lagemaat, Ivayla Ivanova, Andrea Tavosanis, Christian Much, Tania Auchynnikava, Lina Vasiliauskaitė, Marcos Morgan, Juri Rappsilber, Robin C. Allshire, Kamil R. Kranc, David Tollervey, Dónal O'Carroll
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102762- (2021)
Summary: Spermatogonial stem cells (SSCs) sustain spermatogenesis and fertility throughout adult male life. The conserved RNA-binding protein NANOS2 is essential for the maintenance of SSCs, but its targets and mechanisms of function are not fully un
Externí odkaz:
https://doaj.org/article/c901871256cd489d8e9d27e417a6e14f
Autor:
Louie N. van de Lagemaat, Maria Flenley, Magnus D. Lynch, David Garrick, Simon R. Tomlinson, Kamil R. Kranc, Douglas Vernimmen
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-18 (2018)
Abstract Background The mechanism by which protein complexes interact to regulate the deposition of post-translational modifications of histones remains poorly understood. This is particularly important at regulatory regions, such as CpG islands (CGI
Externí odkaz:
https://doaj.org/article/35a4722afad1463599673d8a85287c6a
Autor:
Kirsteen J. Campbell, Louie N. van de Lagemaat, Neil P. Rodrigues, Melania Barile, Berthold Göttgens, Arnaud Villacreces, Catarina Sepulveda, Hannah Lawson, Christopher Mapperley, Amelie V. Guitart, Suzanne Cory, Elise Georges, Joana Campos, Andrea Tavosanis, Aarushi Bellani, Lewis Allen, Catarina Martins-Costa, Kamil R. Kranc, Jozef Durko, Dónal O'Carroll
Publikováno v:
Stem Cell Reports
Summary Hematopoietic stem cells (HSCs) reside at the apex of the hematopoietic differentiation hierarchy and sustain multilineage hematopoiesis. Here, we show that the transcriptional regulator CITED2 is essential for life-long HSC maintenance. Whil
Autor:
Keith Woodley, Laura S Dillingh, George Giotopoulos, Pedro Madrigal, Kevin M Rattigan, Celine Philippe, Vilma Dembitz, Aoife M.S Magee, Ryan Asby, Louie N van de Lagemaat, Christopher Mapperley, Sophie C James, Jochen H.M Prehn, Konstantinos Tzelepis, Kevin Rouault-Pierre, George S Vassiliou, Kamil R Kranc, G Vignir Helgason, Brian J.P Huntly, Paolo Gallipoli
Resistance to standard and novel therapies remains the main obstacle to cure in acute myeloid leukemia (AML) and is often driven by metabolic adaptations which are therapeutically actionable. Here we identify inhibition of mannose-6-phosphate isomera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baa14275e9957db3e0c58ca57602dd3f
https://doi.org/10.1101/2022.05.16.492042
https://doi.org/10.1101/2022.05.16.492042
Autor:
Andrea Tavosanis, Robin C. Allshire, Tania Auchynnikava, Louie N. van de Lagemaat, David Tollervey, Juri Rappsilber, Kamil R. Kranc, Azzurra Codino, Marcos Morgan, Lina Vasiliauskaitė, Ivayla Ivanova, Tomasz W. Turowski, Dónal O'Carroll, Christian Much
Publikováno v:
Codino, A, Turowski, T, Van De Lagemaat, L N, Ivanova, I, Tavosanis, A, Much, C, Auchynnikava, T, Vasiliauskaitė, L, Morgan, M, Rappsilber, J, Allshire, R C, Kranc, K R, Tollervey, D & O'carroll, D 2021, ' NANOS2 is a sequence-specific mRNA-binding protein that promotes transcript degradation in spermatogonial stem cells ', iScience, vol. 24, no. 7, pp. 102762 . https://doi.org/10.1016/j.isci.2021.102762
iScience, Vol 24, Iss 7, Pp 102762-(2021)
iScience
iScience, Vol 24, Iss 7, Pp 102762-(2021)
iScience
Summary Spermatogonial stem cells (SSCs) sustain spermatogenesis and fertility throughout adult male life. The conserved RNA-binding protein NANOS2 is essential for the maintenance of SSCs, but its targets and mechanisms of function are not fully und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f0d604f36300b40fac0b9c874461a3
https://www.pure.ed.ac.uk/ws/files/222714014/PIIS2589004221007306.pdf
https://www.pure.ed.ac.uk/ws/files/222714014/PIIS2589004221007306.pdf
Autor:
Jozef Durko, Andrea Tavosanis, Peter Giles, Hannah Lawson, Alena Shmakova, Nicholas M. Morton, Douglas Vernimmen, Dónal O'Carroll, Marie O'Shea, Neil P. Rodrigues, Amelie V. Guitart, Melania Barile, Andreas Lengeling, Kamil R. Kranc, Roderick N. Carter, Berthold Göttgens, Elise Georges, Milica Vukovic, Lewis Allen, Penny Timms, Catarina Sepulveda, Christopher J. Schofield, Joana Campos, Louie N. van de Lagemaat
Publikováno v:
Blood Adv
Lawson, H, Sepulveda, C, van de Lagemaat, L N, Durko, J, Barile, M, Tavosanis, A, Georges, E, Shmakova, A, Timms, P, Carter, R N, Allen, L, Campos, J, Vukovic, M, Guitart, A V, Giles, P, O'Shea, M, Vernimmen, D, Morton, N M, Rodrigues, N P, Göttgens, B, Schofield, C J, Lengeling, A, O'Carroll, D & Kranc, K R 2021, ' JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells ', Blood Advances, vol. 5, no. 3, pp. 889-899 . https://doi.org/10.1182/bloodadvances.2020002702
Lawson, H, Sepulveda, C, van de Lagemaat, L N, Durko, J, Barile, M, Tavosanis, A, Georges, E, Shmakova, A, Timms, P, Carter, R N, Allen, L, Campos, J, Vukovic, M, Guitart, A V, Giles, P, O'Shea, M, Vernimmen, D, Morton, N M, Rodrigues, N P, Göttgens, B, Schofield, C J, Lengeling, A, O'Carroll, D & Kranc, K R 2021, ' JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells ', Blood Advances, vol. 5, no. 3, pp. 889-899 . https://doi.org/10.1182/bloodadvances.2020002702
Lifelong multilineage hematopoiesis critically depends on rare hematopoietic stem cells (HSCs) that reside in the hypoxic bone marrow microenvironment. Although the role of the canonical oxygen sensor hypoxia-inducible factor prolyl hydroxylase has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9ce5b949122a2f262c58d0ad509090
Autor:
Richard I. Gregory, Daniela S. Krause, Christopher Mapperley, Jun-Ho Choe, Christian Much, Alex von Kriegsheim, Dónal O'Carroll, Joana Campos, David Wotherspoon, Andrea Tavosanis, Adam J. Mead, Jozef Durko, Louie N. van de Lagemaat, Kamil R. Kranc, Annika Sarapuu, Jasmin Paris, Marcos Morgan, Ivayla Ivanova, Hannah Lawson
Publikováno v:
Mapperley, C, Van De Lagemaat, L, Lawson, H, Tavosanis, A, Paris, J, Campos, J, Wotherspoon, D, Durko, J, Sarapuu, A, Choe, J, Ivanova, I, Krause, D S, von Kriegsheim, A, Much, C, Morgan, M, Gregory, R I, Mead, A J, O'Carroll, D & Kranc, K 2020, ' The mRNA m6A reader YTHDF2 supresses pro-inflammatory pathways and sustains hematopoietic stem cell function ', Journal of Experimental Medicine, vol. 218, no. 3, e20200829 . https://doi.org/10.1084/jem.20200829, https://doi.org/10.1084/jem.20200829
The Journal of Experimental Medicine
Mapperley, C, Lagemaat, L N V D, Lawson, H, Tavosanis, A, Paris, J, Campos, J, Wotherspoon, D, Durko, J, Sarapuu, A, Choe, J, Ivanova, I, Krause, D S, Kriegsheim, A V, Much, C, Morgan, M, Gregory, R I, Mead, A J, O’Carroll, D & Kranc, K R 2021, ' The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function ', Journal of Experimental Medicine . https://doi.org/10.1084/jem.20200829
The Journal of Experimental Medicine
Mapperley, C, Lagemaat, L N V D, Lawson, H, Tavosanis, A, Paris, J, Campos, J, Wotherspoon, D, Durko, J, Sarapuu, A, Choe, J, Ivanova, I, Krause, D S, Kriegsheim, A V, Much, C, Morgan, M, Gregory, R I, Mead, A J, O’Carroll, D & Kranc, K R 2021, ' The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function ', Journal of Experimental Medicine . https://doi.org/10.1084/jem.20200829
The m6A reader YTHDF2 is a novel regulator of inflammatory pathways in HSCs. YTHDF2 loss upregulates m6A-modified proinflammatory transcripts, resulting in chronic HSC inflammatory activation, myeloid bias, and functional exhaustion.
The mRNA N6
The mRNA N6
Autor:
Kamil R. Kranc, Frédéric Mazurier, Amelie V. Guitart, Lewis Allen, Andrea Tavosanis, Annika Sarapuu, Milica Vukovic, Louie N. van de Lagemaat, Tim C. P. Somervaille, Gary J. Spencer, Richard I. Gregory, Jun-Ho Choe, Jasmin Paris, Douglas Vernimmen, Christopher Mapperley, Hannah Lawson, Dónal O'Carroll, Alena Shmakova, Christian Much, Joana Campos, Arnaud Villacreces, Catarina Sepulveda, Ali Anvari Azar, David Wotherspoon, Ali Nehme, Marcos Morgan, Ivayla Ivanova
Publikováno v:
Cell Stem Cell
Cell Stem Cell, Cambridge, MA : Cell Press, 2019, 25 (1), pp.137-148.e6. ⟨10.1016/j.stem.2019.03.021⟩
Paris, J, Morgan, M, Monteiro De Campos, J, Spencer, G J, Shmakova, A, Ivanova, I, Mapperley, C, Lawson, H, Wotherspoon, D, Pires Sepulveda, C, Vukovic, M, Allen, L, Sarapuu, A, Tavosanis, A, Guitart, A, Villacreces, A, Much, C, Choe, J, Anvari Azar, A, Van De Lagemaat, L, Vernimmen, D, Nehme, A, Mazurier, F, Somervaille, T C P, Gregory, R I, O'Carroll, D & Kranc, K 2019, ' Targeting the RNA m 6 A reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukemia ', Cell Stem Cell, vol. 25, no. 1, pp. 137-148.E6 . https://doi.org/10.1016/j.stem.2019.03.021
Paris, J, Morgan, M, Campos, J, Spencer, G, Shmakova, E, Ivanova, I, Mapperley, C, Lawson, H, Wotherspoon, D, Sepulveda, C, Vukovic, M, Allen, L, Sarapuu, A, Tavosanis, A, Villacreces, A, Much, C, Choe, J, Azar, A, van de Lagemaat, L, Vernimmen, D, Nehme, A, Mazurier, F, Somervaille, T, Gregory, R, O'Carroll, D & Kranc, K 2019, ' Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia ', Cell Stem Cell, vol. 25, no. 1, e6, pp. 137-148 . https://doi.org/10.1016/j.stem.2019.03.021
Cell Stem Cell, Cambridge, MA : Cell Press, 2019, 25 (1), pp.137-148.e6. ⟨10.1016/j.stem.2019.03.021⟩
Paris, J, Morgan, M, Monteiro De Campos, J, Spencer, G J, Shmakova, A, Ivanova, I, Mapperley, C, Lawson, H, Wotherspoon, D, Pires Sepulveda, C, Vukovic, M, Allen, L, Sarapuu, A, Tavosanis, A, Guitart, A, Villacreces, A, Much, C, Choe, J, Anvari Azar, A, Van De Lagemaat, L, Vernimmen, D, Nehme, A, Mazurier, F, Somervaille, T C P, Gregory, R I, O'Carroll, D & Kranc, K 2019, ' Targeting the RNA m 6 A reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukemia ', Cell Stem Cell, vol. 25, no. 1, pp. 137-148.E6 . https://doi.org/10.1016/j.stem.2019.03.021
Paris, J, Morgan, M, Campos, J, Spencer, G, Shmakova, E, Ivanova, I, Mapperley, C, Lawson, H, Wotherspoon, D, Sepulveda, C, Vukovic, M, Allen, L, Sarapuu, A, Tavosanis, A, Villacreces, A, Much, C, Choe, J, Azar, A, van de Lagemaat, L, Vernimmen, D, Nehme, A, Mazurier, F, Somervaille, T, Gregory, R, O'Carroll, D & Kranc, K 2019, ' Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia ', Cell Stem Cell, vol. 25, no. 1, e6, pp. 137-148 . https://doi.org/10.1016/j.stem.2019.03.021
Acute myeloid leukemia (AML) is an aggressive clonal disorder of hematopoietic stem cells (HSCs) and primitive progenitors that blocks their myeloid differentiation generating self-renewing leukemic stem cells (LSCs). Here we show that the mRNA m6A r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b00b59dad83bf24ff9587c68e68d11
https://hal-univ-tours.archives-ouvertes.fr/hal-02389825
https://hal-univ-tours.archives-ouvertes.fr/hal-02389825