Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Louie N van de Lagemaat"'
Autor:
Alex Bayés, Mark O Collins, Mike D R Croning, Louie N van de Lagemaat, Jyoti S Choudhary, Seth G N Grant
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46683 (2012)
Direct comparison of protein components from human and mouse excitatory synapses is important for determining the suitability of mice as models of human brain disease and to understand the evolution of the mammalian brain. The postsynaptic density is
Externí odkaz:
https://doaj.org/article/342cf640ca6b4fbd9b5c1b3bc2ed6d66
Autor:
René A W Frank, Allan F McRae, Andrew J Pocklington, Louie N van de Lagemaat, Pau Navarro, Mike D R Croning, Noboru H Komiyama, Sophie J Bradley, R A John Challiss, J Douglas Armstrong, Robert D Finn, Mary P Malloy, Alan W MacLean, Sarah E Harris, John M Starr, Sanjeev S Bhaskar, Eleanor K Howard, Sarah E Hunt, Alison J Coffey, Venkatesh Ranganath, Panos Deloukas, Jane Rogers, Walter J Muir, Ian J Deary, Douglas H Blackwood, Peter M Visscher, Seth G N Grant
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19011 (2011)
Current models of schizophrenia and bipolar disorder implicate multiple genes, however their biological relationships remain elusive. To test the genetic role of glutamate receptors and their interacting scaffold proteins, the exons of ten glutamater
Externí odkaz:
https://doaj.org/article/fc8f88c9f5314babada323faa5b3d351
Publikováno v:
PLoS Genetics, Vol 4, Iss 2, p e1000007 (2008)
Endogenous retroviral elements (ERVs) in mice are significant genomic mutagens, causing approximately 10% of all reported spontaneous germ line mutations in laboratory strains. The majority of these mutations are due to insertions of two high copy ER
Externí odkaz:
https://doaj.org/article/e97b7dd587e6456893c8eef3bf8006cf
Publikováno v:
PLoS Genetics, Vol 3, Iss 1, p e10 (2007)
Neuronal apoptosis inhibitory protein (NAIP, also known as BIRC1) is a member of the conserved inhibitor of apoptosis protein (IAP) family. Lineage-specific rearrangements and expansions of this locus have yielded different copy numbers among primate
Externí odkaz:
https://doaj.org/article/16f68ef188b84b25bb22b65a538866ec
Autor:
Irina A Maksakova, Mark T Romanish, Liane Gagnier, Catherine A Dunn, Louie N van de Lagemaat, Dixie L Mager
Publikováno v:
PLoS Genetics, Vol 2, Iss 1, p e2 (2006)
The inbred mouse is an invaluable model for human biology and disease. Nevertheless, when considering genetic mechanisms of variation and disease, it is important to appreciate the significant differences in the spectra of spontaneous mutations that
Externí odkaz:
https://doaj.org/article/cdeef4de68c54c20ae0a333ad491349d
Autor:
Keith Woodley, Laura S. Dillingh, George Giotopoulos, Pedro Madrigal, Kevin M. Rattigan, Céline Philippe, Vilma Dembitz, Aoife M. S. Magee, Ryan Asby, Louie N. van de Lagemaat, Christopher Mapperley, Sophie C. James, Jochen H. M. Prehn, Konstantinos Tzelepis, Kevin Rouault-Pierre, George S. Vassiliou, Kamil R. Kranc, G. Vignir Helgason, Brian J. P. Huntly, Paolo Gallipoli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Resistance to standard and novel therapies remains the main obstacle to cure in acute myeloid leukaemia (AML) and is often driven by metabolic adaptations which are therapeutically actionable. Here we identify inhibition of mannose-6-phospha
Externí odkaz:
https://doaj.org/article/a02c0de22e004847b729037f65f8b163
Autor:
Christine Young, John R. Russell, Louie N. Van De Lagemaat, Hannah Lawson, Christopher Mapperley, Kamil R. Kranc, Maria A. Christophorou
Publikováno v:
Biology Open, Vol 11, Iss 6 (2022)
Peptidylarginine deiminases (PADIs) are strongly associated with the development of autoimmunity, neurodegeneration and cancer but their physiological roles are ill-defined. The nuclear deiminase PADI4 regulates pluripotency in the mammalian pre-impl
Externí odkaz:
https://doaj.org/article/7fbdb19c2f9446879a86422a2d7d277d
Autor:
Azzurra Codino, Tomasz Turowski, Louie N. van de Lagemaat, Ivayla Ivanova, Andrea Tavosanis, Christian Much, Tania Auchynnikava, Lina Vasiliauskaitė, Marcos Morgan, Juri Rappsilber, Robin C. Allshire, Kamil R. Kranc, David Tollervey, Dónal O'Carroll
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102762- (2021)
Summary: Spermatogonial stem cells (SSCs) sustain spermatogenesis and fertility throughout adult male life. The conserved RNA-binding protein NANOS2 is essential for the maintenance of SSCs, but its targets and mechanisms of function are not fully un
Externí odkaz:
https://doaj.org/article/c901871256cd489d8e9d27e417a6e14f
Autor:
Louie N. van de Lagemaat, Maria Flenley, Magnus D. Lynch, David Garrick, Simon R. Tomlinson, Kamil R. Kranc, Douglas Vernimmen
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-18 (2018)
Abstract Background The mechanism by which protein complexes interact to regulate the deposition of post-translational modifications of histones remains poorly understood. This is particularly important at regulatory regions, such as CpG islands (CGI
Externí odkaz:
https://doaj.org/article/35a4722afad1463599673d8a85287c6a
Autor:
Kirsteen J. Campbell, Louie N. van de Lagemaat, Neil P. Rodrigues, Melania Barile, Berthold Göttgens, Arnaud Villacreces, Catarina Sepulveda, Hannah Lawson, Christopher Mapperley, Amelie V. Guitart, Suzanne Cory, Elise Georges, Joana Campos, Andrea Tavosanis, Aarushi Bellani, Lewis Allen, Catarina Martins-Costa, Kamil R. Kranc, Jozef Durko, Dónal O'Carroll
Publikováno v:
Stem Cell Reports
Summary Hematopoietic stem cells (HSCs) reside at the apex of the hematopoietic differentiation hierarchy and sustain multilineage hematopoiesis. Here, we show that the transcriptional regulator CITED2 is essential for life-long HSC maintenance. Whil