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Differentiation of lineage-committed cells from multipotent progenitors requires establishment of accessible chromatin at lineage-specific transcriptional enhancers and promoters, which is mediated by pioneer transcription factors that recruit activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574dbf0cb6b2ae256fd15a555db23eaa
Autor:
O'Brien D, Loughran Sj
Publikováno v:
Nursing standard (Royal College of Nursing (Great Britain) : 1987). 15(22)
There is a high incidence of epilepsy among people with learning disabilities. However, there is no comprehensive strategy for epilepsy care and little research is carried out into health issues and learning disabilities.
Akademický článek
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Autor:
Mansell E; Erasmus MC Hematology, Rotterdam, The Netherlands; Division of Molecular Medicine and Gene Therapy, Lund University, Lund, Sweden. Electronic address: s.mansell@erasmusmc.nl., Lin DS; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Loughran SJ; Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, England, UK., Milsom MD; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany; Division of Experimental Hematology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Trowbridge JJ; The Jackson Laboratory, Bar Harbor, Maine.
Publikováno v:
Experimental hematology [Exp Hematol] 2023 Sep-Oct; Vol. 125-126, pp. 1-5. Date of Electronic Publication: 2023 Jul 09.
Autor:
Bennett C; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Jackson VE; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Pettikiriarachchi A; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Hayman T; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Schaeper U; Silence Therapeutics GmbH, Berlin, Germany., Moir-Meyer G; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Fielding K; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.; Diagnostic Haematology, The Royal Melbourne Hospital, Parkville, VIC, Australia., Ataide R; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Infectious Diseases, Peter Doherty Institute, University of Melbourne, Parkville, VIC, Australia., Clucas D; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.; Diagnostic Haematology, The Royal Melbourne Hospital, Parkville, VIC, Australia., Baldi A; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Garnham AL; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.; Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Li-Wai-Suen CSN; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.; Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Loughran SJ; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Baxter EJ; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Green AR; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Alexander WS; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.; Blood Cells and Blood Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Bahlo M; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Burbury K; Clinical Haematology at the Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, VIC, Australia., Ng AP; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.; Blood Cells and Blood Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Clinical Haematology at the Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, VIC, Australia., Pasricha SR; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.; Diagnostic Haematology, The Royal Melbourne Hospital, Parkville, VIC, Australia.; Clinical Haematology at the Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, VIC, Australia.
Publikováno v:
Blood [Blood] 2023 Jun 29; Vol. 141 (26), pp. 3199-3214.
Autor:
Malouf C; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK., Loughran SJ; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Wilkinson AC; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Shimamura A; Bone Marrow Failure and Myelodysplastic Syndrome Program, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA., Río P; Division of Hematopoietic Innovative Therapies, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER-ISCIII), Madrid, Spain; Advanced Therapies Unit, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD/UAM), Madrid, Spain.
Publikováno v:
Experimental hematology [Exp Hematol] 2022 Jan; Vol. 105, pp. 18-21. Date of Electronic Publication: 2021 Nov 18.
Autor:
Loughran SJ; Wellcome-MRC Cambridge Stem Cell Institute and Department of Haematology, University of Cambridge, Cambridge, United Kingdom. Electronic address: sjl83@cam.ac.uk., Haas S; Heidelberg Institute for Stem Cell Technology and Experimental Medicine and Division of Stem Cells and Cancer, DKFZ German Cancer Research Centre, Heidelberg, Germany., Wilkinson AC; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA; Department of Genetics, Stanford University School of Medicine, Stanford, CA., Klein AM; Department of Systems Biology, Harvard Medical School, Boston, MA., Brand M; Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Publikováno v:
Experimental hematology [Exp Hematol] 2020 Aug; Vol. 88, pp. 1-6. Date of Electronic Publication: 2020 Jul 09.
Autor:
Loughran SJ; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, England, UK.; Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, England, UK., Comoglio F; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, England, UK.; Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, England, UK., Hamey FK; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, England, UK.; Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, England, UK., Giustacchini A; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, England, UK., Errami Y; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, England, UK.; Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, England, UK., Earp E; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, England, UK.; Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, England, UK., Göttgens B; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, England, UK.; Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, England, UK., Jacobsen SEW; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, England, UK.; Wallenberg Institute for Regenerative Medicine, Department of Cell and Molecular Biology and Department of Medicine Huddinge, Karolinska Institutet and Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden., Mead AJ; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, England, UK., Hendrich B; Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, England, UK.; Department of Biochemistry, University of Cambridge, Cambridge, England, UK., Green AR; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, England, UK arg1000@cam.ac.uk.; Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, England, UK.
Publikováno v:
The Journal of experimental medicine [J Exp Med] 2017 Oct 02; Vol. 214 (10), pp. 3085-3104. Date of Electronic Publication: 2017 Sep 12.
Autor:
Nangalia J, Massie CE, Baxter EJ, Nice FL, Gundem G, Wedge DC, Avezov E, Li J, Kollmann K, Kent DG, Aziz A, Godfrey AL, Hinton J, Martincorena I, Van Loo P, Jones AV, Guglielmelli P, Tarpey P, Harding HP, Fitzpatrick JD, Goudie CT, Ortmann CA, Loughran SJ, Raine K, Jones DR, Butler AP, Teague JW, O'Meara S, McLaren S, Bianchi M, Silber Y, Dimitropoulou D, Bloxham D, Mudie L, Maddison M, Robinson B, Keohane C, Maclean C, Hill K, Orchard K, Tauro S, Du MQ, Greaves M, Bowen D, Huntly BJP, Harrison CN, Cross NCP, Ron D, Vannucchi AM, Papaemmanuil E, Campbell PJ, Green AR
Publikováno v:
The New England journal of medicine [N Engl J Med] 2013 Dec 19; Vol. 369 (25), pp. 2391-2405. Date of Electronic Publication: 2013 Dec 10.