Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid.

Autor: Pan M, Zhang Y, Wright WC, Liu X, Passaia B, Currier D, Low J, Chapple RH, Steele JA, Connelly JP, Lu M, Lee HM, Loughran AJ, Yang L, Abraham BJ, Pruett-Miller SM, Freeman B, Campbell GE, Dyer MA, Chen T, Stewart E, Koo S, Sheppard H, Easton J, Geeleher P

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 14. Date of Electronic Publication: 2024 May 14.

Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines.

Autor: Nishiguchi G; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Mascibroda LG; Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Young SM; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Caine EA; Promega Corporation, 5430 East Cheryl Drive, Madison, WI, 53711, USA., Abdelhamed S; Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Kooijman JJ; Oncolines B.V., Kloosterstraat 9, 5349 AB, Oss, The Netherlands., Miller DJ; Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Das S; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., McGowan K; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Mayasundari A; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Shi Z; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Barajas JM; Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Hiltenbrand R; Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Aggarwal A; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Chang Y; Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Mishra V; Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Narina S; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Thomas M; Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Loughran AJ; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Kalathur R; Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Yu K; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Zhou S; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Wang X; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., High AA; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Peng J; Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Pruett-Miller SM; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Memphis, TN, 38105, USA., Daniels DL; Promega Corporation, 5430 East Cheryl Drive, Madison, WI, 53711, USA., Urh M; Promega Corporation, 5430 East Cheryl Drive, Madison, WI, 53711, USA., Shelat AA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Mullighan CG; Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Riching KM; Promega Corporation, 5430 East Cheryl Drive, Madison, WI, 53711, USA., Zaman GJR; Oncolines B.V., Kloosterstraat 9, 5349 AB, Oss, The Netherlands., Fischer M; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA. marcus.fischer@stjude.org., Klco JM; Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA. jeffery.klco@stjude.org., Rankovic Z; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA. zoran.rankovic@stjude.org.

Publikováno v: Nature communications [Nat Commun] 2024 Jan 16; Vol. 15 (1), pp. 482. Date of Electronic Publication: 2024 Jan 16.

Bacterial TLR2/6 Ligands Block Ciliogenesis, Derepress Hedgehog Signaling, and Expand the Neocortex.

Autor: Mann B; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Crawford JC; Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Reddy K; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Lott J; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Youn YH; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Gao G; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Guy C; Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Chou CH; Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Darnell D; Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Trivedi S; Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Bomme P; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Loughran AJ; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Thomas PG; Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Han YG; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Tuomanen EI; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

Publikováno v: MBio [mBio] 2023 Jun 27; Vol. 14 (3), pp. e0051023. Date of Electronic Publication: 2023 Apr 13.

Poly (acetyl, arginyl) glucosamine disrupts Pseudomonas aeruginosa biofilms and enhances bacterial clearance in a rat lung infection model.

Autor: Garcia BA; Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Medical University of South Carolina, Charleston, SC, USA.; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA., McDaniel MS; Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA., Loughran AJ; Synedgen, Inc., Claremont, CA, USA.; St Jude Children's Research Hospital, Memphis, TN, USA., Johns JD; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA., Narayanaswamy V; Synedgen, Inc., Claremont, CA, USA., Fernandez Petty C; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA., Birket SE; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Department of Cell Developmental and Integrative Physiology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Baker SM; Synedgen, Inc., Claremont, CA, USA.; Synspira Therapeutics, Inc., Framingham, MA, USA., Barnaby R; Dartmouth Cystic Fibrosis Research Center, New Hanover, NH, USA., Stanton BA; Dartmouth Cystic Fibrosis Research Center, New Hanover, NH, USA., Foote JB; Comparative Pathology Laboratory, at University of Alabama at Birmingham, Birmingham, Alabama, USA., Rowe SM; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Department of Cell Developmental and Integrative Physiology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Swords WE; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Publikováno v: Microbiology (Reading, England) [Microbiology (Reading)] 2022 Jan; Vol. 168 (1).

Label-Free Proteomic Approach to Characterize Protease-Dependent and -Independent Effects of sarA Inactivation on the Staphylococcus aureus Exoproteome.

Autor: Byrum SD; Department of Biochemistry and Molecular Biology , University of Arkansas for Medical Sciences , 4301 West Markham Street , Little Rock , Arkansas 72205 , United States.; Arkansas Children's Research Institute , 13 Children's Way , Little Rock , Arkansas 72202 , United States., Loughran AJ; Department of Microbiology and Immunology , University of Arkansas for Medical Sciences , 4301 West Markham Street , Little Rock , Arkansas 72205 , United States., Beenken KE; Department of Microbiology and Immunology , University of Arkansas for Medical Sciences , 4301 West Markham Street , Little Rock , Arkansas 72205 , United States., Orr LM; Department of Biochemistry and Molecular Biology , University of Arkansas for Medical Sciences , 4301 West Markham Street , Little Rock , Arkansas 72205 , United States., Storey AJ; Department of Biochemistry and Molecular Biology , University of Arkansas for Medical Sciences , 4301 West Markham Street , Little Rock , Arkansas 72205 , United States., Mackintosh SG; Department of Biochemistry and Molecular Biology , University of Arkansas for Medical Sciences , 4301 West Markham Street , Little Rock , Arkansas 72205 , United States., Edmondson RD; Department of Biochemistry and Molecular Biology , University of Arkansas for Medical Sciences , 4301 West Markham Street , Little Rock , Arkansas 72205 , United States., Tackett AJ; Department of Biochemistry and Molecular Biology , University of Arkansas for Medical Sciences , 4301 West Markham Street , Little Rock , Arkansas 72205 , United States.; Arkansas Children's Research Institute , 13 Children's Way , Little Rock , Arkansas 72202 , United States., Smeltzer MS; Department of Microbiology and Immunology , University of Arkansas for Medical Sciences , 4301 West Markham Street , Little Rock , Arkansas 72205 , United States.

Publikováno v: Journal of proteome research [J Proteome Res] 2018 Oct 05; Vol. 17 (10), pp. 3384-3395. Date of Electronic Publication: 2018 Sep 27.