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Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Phosphoenolpyruvate carboxykinase (PEPCK) is a gluconeogenic enzyme with a cytosolic (Pck1/PEPCK-C) and mitochondrial (Pck2/PEPCK-M) isoform. Here we investigate the effect of 3-mercaptopicolinic acid (3-MPA), a PEPCK inhibitor, on C2C12 mus
Externí odkaz:
https://doaj.org/article/700ab5aa868d43ae891ddb46d418f63a
Autor:
Montgomery-Csobán, Tünde, Kavanagh, Kimberley, Murray, Paul, Robertson, Chris, Barry, Sarah J E, Vivian Ukah, U, Payne, Beth A, Nicolaides, Kypros H, Syngelaki, Argyro, Ionescu, Olivia, Akolekar, Ranjit, Hutcheon, Jennifer A, Magee, Laura A, von Dadelszen, Peter, Brown, Mark A., Davis, Gregory K., Parker, Claire, Walters, Barry N., Sass, Nelson, Ansermino, J. Mark, Cao, Vivien, Cundiff, Geoffrey W., von Dadelszen, Emma C.M., Douglas, M. Joanne, Dumont, Guy A., Dunsmuir, Dustin T., Hutcheon, Jennifer A., Joseph, K.S., Lalji, Sayrin, Lee, Tang, Li, Jing, Lim, Kenneth I., Lisonkova, Sarka, Lott, Paula, Menzies, Jennifer M., Millman, Alexandra L., Palmer, Lynne, Payne, Beth A., Qu, Ziguang, Russell, James A., Sawchuck, Diane, Shaw, Dorothy, Still, D. Keith, Ukah, U. Vivian, Wagner, Brenda, Walley, Keith R., Hugo, Dany, Gruslin, The late Andrée, Tawagi, George, Smith, Graeme N., Côté, Anne-Marie, Moutquin, Jean-Marie, Ouellet, Annie B., Lee, Shoo K., Duan, Tao, Zhou, Jian, Haniff, The late Farizah, Mahajan, Swati, Noovao, Amanda, Karjalainend, Hanna, Kortelainen, Alja, Laivuori, Hannele, Ganzevoort, J. Wessel, Groen, Henk, Kyle, Phillipa M., Moore, M. Peter, Pullar, Barbra, Bhutta, Zulfiqar A., Qureshi, Rahat N., Sikandar, Rozina, Bhutta, The late Shereen Z., Cloete, Garth, Hall, David R., van Papendorp, The late Erika, Steyn, D. Wilhelm, Biryabarema, Christine, Mirembe, Florence, Nakimuli, Annettee, Allotey, John, Thangaratinam, Shakila, Nicolaides, Kypros H., Ionescu, Olivia, Syngelaki, Argyro, de Swiet, Michael, Magee, Laura A., von Dadelszen, Peter, Akolekar, Ranjit, Walker, James J., Robson, Stephen C., Broughton-Pipkin, Fiona, Loughna, Pamela, Vatish, Manu, Redman, Christopher W.G., Barry, Sarah J.E., Kavanagh, Kimberley, Montgomery-Csobán, Tunde, Murray, Paul, Robertson, Chris, Tsigas, Eleni Z., Woelkers, Douglas A., Lindheimer, Marshall D., Grobman, William A., Sibai, Baha M., Merialdi, Mario, Widmer, Mariana
Publikováno v:
The Lancet Digital Health; April 2024, Vol. 6 Issue: 4 pe238-e250, 13p
Publikováno v:
Biochemistry and Biophysics Reports, Vol 25, Iss , Pp 100924- (2021)
Myosin heavy chain-IIB (MyHC-IIB; encoded by MYH4 or Myh4) expression is often associated with muscle hypertrophic growth. Unlike other large mammals, domestic pig breeds express MyHC-IIB at both the mRNA and protein level. Aim: To utilise a fluoresc
Externí odkaz:
https://doaj.org/article/e247c00942fe4dd6a3cce99cc8c86ce6
Autor:
Madelaine C. Brearley, Congcong Li, Zoe C.T.R. Daniel, Paul T. Loughna, Tim Parr, John M. Brameld
Publikováno v:
Biochemistry and Biophysics Reports, Vol 20, Iss , Pp - (2019)
Skeletal muscle is a highly metabolic and dynamic tissue that is formed through the complex and well-organised process of myogenesis. Although there is a good understanding about the role of the Muscle Regulatory Factors during myogenesis, little is
Externí odkaz:
https://doaj.org/article/b3684d69a1f245e08e3c739ee194d37c
Autor:
Zoe Redshaw, Paul Thomas Loughna
Publikováno v:
Frontiers in Veterinary Science, Vol 5 (2018)
Intramuscular fat is important in large animal livestock species in regard to meat quality and in humans is of clinical significance in particular in relation to insulin resistance. The canonical Wnt signalling pathway has been implicated at a whole
Externí odkaz:
https://doaj.org/article/0b993f0be58841bca141bb3194316504
Autor:
Tushar K. Ghosh, Javier T. Granados-Riveron, Sarah Buxton, Kerry Setchfield, Siobhan Loughna, J. David Brook
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 1, Iss 1, Pp 134-145 (2014)
Congenital heart disease (CHD) affects the intricate structure and function of the heart and is one of the leading causes of death in newborns. The genetic basis of CHD is beginning to emerge. Our laboratory has been engaged in identifying mutations
Externí odkaz:
https://doaj.org/article/7fe6ee008d754859824c1314ac3928f3
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 4, Pp 4433-4445 (2012)
Ion channels play important roles in chondrocyte mechanotransduction. The transient receptor potential vanilloid (TRPV) subfamily of ion channels consists of six members. TRPV1-4 are temperature sensitive calcium-permeable, relatively non-selective c
Externí odkaz:
https://doaj.org/article/2b4b2a1b81ad41e3940a9bb09b77e39a
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 4, Iss 3, p 8 (2017)
Animals have frequently been used as models for human disorders and mutations. Following advances in genetic testing and treatment options, and the decreasing cost of these technologies in the clinic, mutations in both companion and commercial animal
Externí odkaz:
https://doaj.org/article/e2dff17899454a1a9055042b22aef21c
Publikováno v:
In Placenta 2009 30(8):726-730