Plasmodium falciparum activates CD16+ dendritic cells to produce TNF and IL-10 in subpatent malaria

Autor: Loughland, JR, Woodberry, T, Boyle, MJ, Tipping, PE, Piera, KA, Amante, FH, Kenangalem, E, Price, RN, Engwerda, CR, Anstey, NM, McCarthy, JS, Minigo, G

The malaria causing parasite Plasmodium subverts host immune responses by several strategies including the modulation of dendritic cells (DCs). Here, we show P. falciparum skewed CD16+ DC cytokine responses towards IL-10 production in vitro, distinct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4f2861aa595bf3c003e9c30df1eebfa3
https://doi.org/10.1093/infdis/jiy555

Single cell transcriptomics shows that malaria promotes unique regulatory responses across multiple immune cell subsets.

Autor: Dooley NL; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; School of Environment and Sciences, Griffith University, Brisbane, QLD, Australia., Chabikwa TG; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Pava Z; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Loughland JR; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Hamelink J; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; University of Queensland, Brisbane, QLD, Australia., Berry K; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; Queensland University of Technology, Brisbane, QLD, Australia., Andrew D; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Soon MSF; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., SheelaNair A; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Piera KA; Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia., William T; Infectious Diseases Society Kota Kinabalu Sabah-Menzies School of Health Research Program, Kota Kinabalu, Sabah, Malaysia.; Subang Jaya Medical Centre, Selangor, Malaysia., Barber BE; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.; Infectious Diseases Society Kota Kinabalu Sabah-Menzies School of Health Research Program, Kota Kinabalu, Sabah, Malaysia., Grigg MJ; Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.; Infectious Diseases Society Kota Kinabalu Sabah-Menzies School of Health Research Program, Kota Kinabalu, Sabah, Malaysia., Engwerda CR; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Lopez JA; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; School of Environment and Sciences, Griffith University, Brisbane, QLD, Australia., Anstey NM; Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.; Infectious Diseases Society Kota Kinabalu Sabah-Menzies School of Health Research Program, Kota Kinabalu, Sabah, Malaysia., Boyle MJ; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. michelle.boyle@burnet.edu.au.; School of Environment and Sciences, Griffith University, Brisbane, QLD, Australia. michelle.boyle@burnet.edu.au.; University of Queensland, Brisbane, QLD, Australia. michelle.boyle@burnet.edu.au.; Queensland University of Technology, Brisbane, QLD, Australia. michelle.boyle@burnet.edu.au.; Burnet Institute, Melbourne, VIC, Australia. michelle.boyle@burnet.edu.au.

Publikováno v: Nature communications [Nat Commun] 2023 Nov 15; Vol. 14 (1), pp. 7387. Date of Electronic Publication: 2023 Nov 15.

IL-10-producing Th1 cells possess a distinct molecular signature in malaria.

Autor: Edwards CL, Ng SS, de Labastida Rivera F, Corvino D, Engel JA, Montes de Oca M, Bukali L, Frame TC, Bunn PT, Chauhan SB, Singh SS, Wang Y, Na J, Amante FH, Loughland JR, Soon MS, Waddell N, Mukhopadhay P, Koufariotis LT, Johnston RL, Lee JS, Kuns R, Zhang P, Boyle MJ, Hill GR, McCarthy JS, Kumar R, Engwerda CR

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2023 Feb 15; Vol. 133 (4). Date of Electronic Publication: 2023 Feb 15.

Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children.

Autor: Oyong DA; Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia; Charles Darwin University, Darwin, NT, Australia., Loughland JR; Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Soon MSF; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Chan JA; Burnet Institute, Melbourne, VIC, Australia; Department of Immunology, Central Clinical School, Monash University, VIC, Australia; Department of Medicine, University of Melbourne, VIC, Australia., Andrew D; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Wines BD; Burnet Institute, Melbourne, VIC, Australia; Department of Immunology, Central Clinical School, Monash University, VIC, Australia; Department of Clinical Pathology, University of Melbourne, VIC, Australia., Hogarth PM; Burnet Institute, Melbourne, VIC, Australia; Department of Immunology, Central Clinical School, Monash University, VIC, Australia; Department of Clinical Pathology, University of Melbourne, VIC, Australia., Olver SD; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Collinge AD; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Varelias A; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; Faculty of Medicine, The University of Queensland, QLD, Australia., Beeson JG; Burnet Institute, Melbourne, VIC, Australia; Department of Medicine, University of Melbourne, VIC, Australia; Department of Microbiology, Monash University, VIC, Australia., Kenangalem E; Timika Malaria Research Program, Papuan Health and Community Development Foundation, Timika, Papua, Indonesia; District Health Authority, Timika, Papua, Indonesia., Price RN; Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Anstey NM; Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia., Minigo G; Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia; Charles Darwin University, Darwin, NT, Australia., Boyle MJ; Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; Burnet Institute, Melbourne, VIC, Australia; Faculty of Medicine, The University of Queensland, QLD, Australia. Electronic address: michelle.boyle@qimrberghofer.edu.au.

Publikováno v: EBioMedicine [EBioMedicine] 2022 Jan; Vol. 75, pp. 103784. Date of Electronic Publication: 2021 Dec 27.

Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians.

Autor: Hensen L; Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3000, Australia., Nguyen THO; Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3000, Australia., Rowntree LC; Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3000, Australia., Damelang T; Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3000, Australia., Koutsakos M; Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3000, Australia., Aban M; World Health Organization Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Hurt A; World Health Organization Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Harland KL; Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3000, Australia., Auladell M; Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3000, Australia., van de Sandt CE; Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3000, Australia.; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX Amsterdam, The Netherlands., Everitt A; Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia., Blacker C; Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia., Oyong DA; Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia.; Center for Global Infectious Disease Research (CGIDR), Seattle Children's Research Institute, Seattle, WA 98109., Loughland JR; Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia.; Immunology Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia., Webb JR; Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia., Wines BD; Immune Therapies Laboratory, Burnet Institute, Melbourne, VIC 3084, Australia.; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC 3010, Australia.; Department of Clinical Pathology, The University of Melbourne, Parkville, VIC 3010, Australia., Hogarth PM; Immune Therapies Laboratory, Burnet Institute, Melbourne, VIC 3084, Australia.; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC 3010, Australia.; Department of Clinical Pathology, The University of Melbourne, Parkville, VIC 3010, Australia., Flanagan KL; Tasmanian Vaccine Trial Centre, Clifford Craig Foundation, Launceston General Hospital, Launceston, TAS 7250, Australia.; School of Health Sciences and School of Medicine, University of Tasmania, Launceston, TAS 7248, Australia.; Department of Immunology and Pathology, Monash University, Melbourne, VIC 3800, Australia.; School of Health and Biomedical Science, Royal Melbourne Institute of Technology, Melbourne, VIC 3000, Australia., Plebanski M; School of Health and Biomedical Science, Royal Melbourne Institute of Technology, Melbourne, VIC 3000, Australia., Wheatley A; Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3000, Australia.; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Melbourne, VIC 3010, Australia., Chung AW; Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3000, Australia., Kent SJ; Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3000, Australia.; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Melbourne, VIC 3010, Australia.; Infectious Diseases Department, Melbourne Sexual Health Centre, Alfred Health, Central Clinical School, Monash University, Melbourne, VIC 3053, Australia., Miller A; Indigenous Engagement, Central Queensland University, Townsville, QLD 4810, Australia., Clemens EB; Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3000, Australia., Doherty PC; Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3000, Australia; pcd@unimelb.edu.au kkedz@unimelb.edu.au.; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105., Nelson J; Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia., Davies J; Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia.; Department of Infectious Diseases, Royal Darwin Hospital, Darwin, NT 0810, Australia., Tong SYC; Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia.; Victorian Infectious Diseases Service, The Royal Melbourne Hospital and The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3000, Australia., Kedzierska K; Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3000, Australia; pcd@unimelb.edu.au kkedz@unimelb.edu.au.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Oct 12; Vol. 118 (41).