Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2.

Autor: Scott DC; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Dharuman S; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Griffith E; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Chai SC; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Ronnebaum J; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., King MT; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Tangallapally R; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Lee C; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Gee CT; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Yang L; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Li Y; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Loudon VC; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Lee HW; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Ochoada J; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Miller DJ; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Jayasinghe T; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Elledge SJ; Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA, USA., Harper JW; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Chen T; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Lee RE; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA. Richard.Lee@Stjude.org., Schulman BA; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA. schulman@biochem.mpg.de.; Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany. schulman@biochem.mpg.de.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 12; Vol. 15 (1), pp. 8829. Date of Electronic Publication: 2024 Oct 12.