Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Loudon Julia Mary"'
1
Design of [R-(Z)]-(+)-α-(Methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitrile (SB 202026), a Functionally Selective Azabicyclic Muscarinic M1 Agonist Incorporating the N-Methoxy Imidoyl Nitrile Group as a Novel Ester Bioisostere
Autor: Frederick Cassidy, Julie Hawkins, Barry Sidney Orlek, Steven Mark Bromidge, Christopher B. Naylor, Frank Brown, Michael S. G. Clark, Loudon Julia Mary, Michael S. Hadley, Graham J. Riley, Steven Dabbs
Publikováno v: Journal of Medicinal Chemistry. 40:4265-4280
Loss of cholinergic function is believed to be implicated in the cognitive decline associated with senile dementia of the Alzheimer type (SDAT). The disease is characterized by progressive loss of muscarinic receptors located on nerve terminals while
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff9388fbee61638fba8b02c20f5bc46
https://doi.org/10.1021/jm9702903
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2
1,2,5,6-tetrahydropyridine oxime ethers incorporating electron withdrawing groups are potent and selective muscarinic agonists
Autor: Barry Sidney Orlek, Graham J. Riley, Richard E. Faulkner, Steven Mark Bromidge, Frank Brown, Michael S. G. Clark, Frederick Cassidy, Loudon Julia Mary, Steven Dabbs, Emma J. Collings
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:557-562
The combination of N-methoxy imidoyl halide and nitrile moieties with the 1,2,5,6-tetrahydropyridine ring system afforded a novel series of potent muscarinic agonists. Members of this class, exemplified by the imidoyl nitriles 2c and 3c , show favour
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d45b16026111b228491b57c2df1f13e
https://doi.org/10.1016/s0960-894x(01)80154-2
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3
ChemInform Abstract: Synthesis and Evaluation of a Series of Aryl(e)fused Pyrazolo(4,3-c) pyridines with Potential Anxiolytic Activity
Autor: Ian Thomson Forbes, Loudon Julia Mary, Jane M. Nicholass, Christopher N. Johnson, Mervyn Thompson, Neil Upton, G. E. Jones
Publikováno v: ChemInform. 22
A series of pyrazolo[4,3-c]pyridines has been synthesized and evaluated as potential anxiolytic agents. Selected compounds from this series show a pharmacological profile of action different from that of diazepam. A number of the compounds possess hi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0cfd429f1f1d15010e557dd6f90fdbac
https://doi.org/10.1002/chin.199108211
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4
ChemInform Abstract: 1,2,5,6-Tetrahydropyridine Oxime Ethers Incorporating Electron Withdrawing Groups are Potent and Selective Muscarinic Agonists
Autor: Frank Brown, Steven Mark Bromidge, Graham J. Riley, Emma J. Collings, Loudon Julia Mary, Barry Sidney Orlek, Richard E. Faulkner, Frederick Cassidy, Michael S. G. Clark, Steven Dabbs
Publikováno v: ChemInform. 25
The combination of N-methoxy imidoyl halide and nitrile moieties with the 1,2,5,6-tetrahydropyridine ring system afforded a novel series of potent muscarinic agonists. Members of this class, exemplified by the imidoyl nitriles 2c and 3c , show favour
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7939ce7c88bc532d4d5b011567f0492
https://doi.org/10.1002/chin.199434167
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5
Synthesis and evaluation of a series of aryl[e]fused pyrazolo[4,3-c]pyridines with potential anxiolytic activity
Autor: Christopher N. Johnson, Ian Thomson Forbes, Jane M. Nicholass, G. E. Jones, Loudon Julia Mary, Neil Upton, Mervyn Thompson
Publikováno v: Journal of medicinal chemistry. 33(9)
A series of pyrazolo[4,3-c]pyridines has been synthesized and evaluated as potential anxiolytic agents. Selected compounds from this series show a pharmacological profile of action different from that of diazepam. A number of the compounds possess hi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06f9fbd82e9a170d69b00e97c597f8e
https://pubmed.ncbi.nlm.nih.gov/1975276
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8
Enhancement of [3H]flunitrazepam binding by mianserin, in vivo
Autor: Fatima Jeevanjee, Jane M. Nicholass, Loudon Julia Mary, Anthony M. Johnson
Publikováno v: Neuroscience letters. 46(3)
Mianserin (5–20 mg/kg), like chlordiazepoxide (2.5–10 mg/kg), inhibits the shock-induced suppression of drinking (SSD) in rats. However, in contrast to chlordiazepoxide, the effect of mianserin is not blocked by the benzodiazepine antagonist, Ro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f706b86f203a3992160804bf7e3f35b
https://pubmed.ncbi.nlm.nih.gov/6330626
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