Metformine et cancer : de nouvelles perspectives pour un ancien médicament

Autor: Loubière, Camille, Dirat, Béatrice, Tanti, Jean-François, Bost, Frédéric

Publikováno v: In Annales d'Endocrinologie May 2013 74(2):130-136

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells

Autor: Loubiere, Camille, Clavel, Stephan, Gilleron, Jerome, Harisseh, Rania, Fauconnier, Jeremy, Ben-Sahra, Issam, Kaminski, Lisa, Laurent, Kathiane, Herkenne, Stephanie, Lacas-Gervais, Sandra, Ambrosetti, Damien, Alcor, Damien, Rocchi, Stephane, Cormont, Mireille, Michiels, Jean-François, Mari, Bernard, Mazure, Nathalie M., Scorrano, Luca, Lacampagne, Alain, Gharib, Abdallah, Tanti, Jean-François, Bost, Frederic

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), ⟨10.1038/s41598-017-05052-2⟩
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports (7), 1-9. (2017)
Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.1-9. ⟨10.1038/s41598-017-05052-2⟩

International audience; Mitochondrial integrity is critical for the regulation of cellular energy and apoptosis. Metformin is an energy disruptor targeting complex I of the respiratory chain. We demonstrate that metformin induces endoplasmic reticulu

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The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells.

Autor: Loubiere C; Inserm U1065, C3M, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France.; Université Nice Côte d'Azur, Inserm, Nice, France., Clavel S; Inserm U1065, C3M, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France.; Université Nice Côte d'Azur, Inserm, Nice, France., Gilleron J; Inserm U1065, C3M, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France.; Université Nice Côte d'Azur, Inserm, Nice, France., Harisseh R; Inserm U1060/ INRA 1235/ Université-Lyon1/ INSA, Lyon, France., Fauconnier J; Inserm U1046, UMR CNRS 9214, Université de Montpellier, Montpellier, France., Ben-Sahra I; Northwestern University, Chicago, IL, USA., Kaminski L; Inserm U1065, C3M, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France.; Université Nice Côte d'Azur, Inserm, Nice, France., Laurent K; Inserm U1065, C3M, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France.; Université Nice Côte d'Azur, Inserm, Nice, France., Herkenne S; Department of Biology, University of Padua, Padua, Italy.; Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Padua, Italy., Lacas-Gervais S; Centre Commun de Microscopie Appliquée, Université de Nice Sophia-Antipolis, Nice, France., Ambrosetti D; Centre Hospitalier Universitaire (CHU) de Nice, Hôpital Pasteur, Laboratoire Central d'Anatomo Pathologie, 06002, Nice, France., Alcor D; Inserm U1065, C3M, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France.; Université Nice Côte d'Azur, Inserm, Nice, France., Rocchi S; Université Nice Côte d'Azur, Inserm, Nice, France.; Inserm U1065, C3M, Team Biology and pathology of melanocyte cells: From skin pigmentation to melanomas, Nice, France., Cormont M; Inserm U1065, C3M, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France.; Université Nice Côte d'Azur, Inserm, Nice, France., Michiels JF; Centre Hospitalier Universitaire (CHU) de Nice, Hôpital Pasteur, Laboratoire Central d'Anatomo Pathologie, 06002, Nice, France., Mari B; CNRS, Institute of Molecular and Cellular Pharmacology, Sophia Antipolis, France., Mazure NM; Institute for Research on Cancer and Aging of Nice, CNRS-UMR 7284-Inserm U1081, University of Nice Sophia-Antipolis, Centre Antoine Lacassagne, Nice, France., Scorrano L; Department of Biology, University of Padua, Padua, Italy.; Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Padua, Italy., Lacampagne A; Inserm U1046, UMR CNRS 9214, Université de Montpellier, Montpellier, France., Gharib A; Inserm U1060/ INRA 1235/ Université-Lyon1/ INSA, Lyon, France., Tanti JF; Inserm U1065, C3M, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France.; Université Nice Côte d'Azur, Inserm, Nice, France., Bost F; Inserm U1065, C3M, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France. bost@unice.fr.; Université Nice Côte d'Azur, Inserm, Nice, France. bost@unice.fr.

Publikováno v: Scientific reports [Sci Rep] 2017 Jul 11; Vol. 7 (1), pp. 5040. Date of Electronic Publication: 2017 Jul 11.