Zobrazeno 1 - 10 of 28 pro vyhledávání: '"LouAnn Cable"'
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Akademický článek
Methylation of dual-specificity phosphatase 4 controls cell differentiation
Autor: Hairui Su, Ming Jiang, Chamara Senevirathne, Srinivas Aluri, Tuo Zhang, Han Guo, Juliana Xavier-Ferrucio, Shuiling Jin, Ngoc-Tung Tran, Szu-Mam Liu, Chiao-Wang Sun, Yongxia Zhu, Qing Zhao, Yuling Chen, LouAnn Cable, Yudao Shen, Jing Liu, Cheng-Kui Qu, Xiaosi Han, Christopher A. Klug, Ravi Bhatia, Yabing Chen, Stephen D. Nimer, Y. George Zheng, Camelia Iancu-Rubin, Jian Jin, Haiteng Deng, Diane S. Krause, Jenny Xiang, Amit Verma, Minkui Luo, Xinyang Zhao
Publikováno v: Cell Reports, Vol 36, Iss 4, Pp 109421- (2021)
Summary: Mitogen-activated protein kinases (MAPKs) are inactivated by dual-specificity phosphatases (DUSPs), the activities of which are tightly regulated during cell differentiation. Using knockdown screening and single-cell transcriptional analysis
Externí odkaz: https://doaj.org/article/c390eca951f14661aa1b8d2ec69d2ff2
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6
Data from Impact of Common Epidermal Growth Factor Receptor and HER2 Variants on Receptor Activity and Inhibition by Lapatinib
Autor: Edgar R. Wood, Lisa Shewchuk, Anne T. Truesdale, H. Luke Carter, Ermias Woldu, Kathleen T. Gallagher, Glenn Spehar, David Rusnak, Krystal Alligood, Louann Cable, Tona M. Gilmer
The goal of this study was to characterize the effects of non–small cell lung carcinoma (NSCLC)-associated mutations in epidermal growth factor receptor (EGFR/ErbB1) and HER2 (ErbB2) on interactions with the dual tyrosine kinase inhibitor lapatinib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4634a8f47176a77086f78bb49fe819c
https://doi.org/10.1158/0008-5472.c.6497225
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8
Abstract 147: Bezuclastinib is a differentiated KIT inhibitor that exhibits unique selectivity to KIT A-loop mutations, minimal brain penetration, and favorable pharmacokinetic properties in preclinical models
Autor: Anna Guarnieri, Karyn Bouhana, LouAnn Cable, Rob Rieger, Leyla Haygood, John Robinson, Shannon Winski
Publikováno v: Cancer Research. 82:147-147
KIT is a well characterized oncogenic driver, mutated in up to 80% of gastro-intestinal stromal tumors (GIST). Front-line imatinib is effective in many patients but durable responses in the setting of imatinib failure are rarely achieved due to compl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c406443cea177d1f9129e77df0b6827f
https://doi.org/10.1158/1538-7445.am2022-147
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Abstract P257: Preclinical data identifies bezuclastinib as a differentiated KIT inhibitor with unique selectivity to KIT D816V and minimal evidence of brain penetration
Autor: Anna Guarnieri, Mark Chicarelli, LouAnn Cable, Francis Sullivan, Howard Ball, Shannon Winski, John Robinson
Publikováno v: Molecular Cancer Therapeutics. 20:P257-P257
KIT is a well characterized oncogenic driver of gastro-intestinal stromal tumors (GIST) and systemic mastocytosis (SM), and targeted therapeutics have offered valuable treatment options for these patients. Durable responses in imatinib-resistant GIST
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::750c204c56b3e9b376a25331c63c327d
https://doi.org/10.1158/1535-7163.targ-21-p257
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10
Preclinical Data with KIT D816V Inhibitor Bezuclastinib (CGT9486) Demonstrates High Selectivity and Minimal Brain Penetrance
Autor: John A. Robinson, Francis J. Sullivan, Jessica Sachs, Howard Ball, Karyn Bouhana, Shannon L. Winski, LouAnn Cable, Mark Joseph Chicarelli, Anna Guarnieri
Publikováno v: Blood. 138:4595-4595
The molecular pathogenesis of Systemic Mastocytosis (SM) is driven by mutations in the KIT gene, with 95% of patients having a mutation in exon 17, D816V, leading to constant proliferation of mast cells (Garcia-Montero et al, 2006; Jara-Acevedo et al
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe83c1302fd6bd0cc4c1d16e4637dd2e
https://doi.org/10.1182/blood-2021-152770
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