Myosin efflux promotes cell elongation to coordinate chromosome segregation with cell cleavage

Autor: Emilie Montembault, Marie-Charlotte Claverie, Lou Bouit, Cedric Landmann, James Jenkins, Anna Tsankova, Clemens Cabernard, Anne Royou

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

Chromatid segregation must be coordinated with cytokinesis to preserve genomic stability. Here the authors show that cells clear trailing chromatids from the cleavage site in a two-step cell elongation and demonstrate the role of myosin efflux in the

Externí odkaz: https://doaj.org/article/fdf331d591bd4b8ebc35bc1260ab985e

The atypical Rho GTPase Rnd2 is critical for dentate granule neuron development and anxiety-like behavior during adult but not neonatal neurogenesis

Autor: Lou Bouit, Delphine Gonzales, Pierre Mortessagne, David Perrais, Geoffrey Terral, Adeline Goron, Marlène Maitre, Emilie Pacary, François Guillemot, Thierry Leste-Lasserre, Thomas Kerloch, Julian Ik-Tsen Heng, Muriel Koehl, Fanny Farrugia, Hélène Doat, Mylène Blanchard, Djoher Nora Abrous

Publikováno v: Molecular Psychiatry
Molecular Psychiatry, Nature Publishing Group, In press, ⟨10.1038/s41380-021-01301-z⟩
Molecular Psychiatry, Nature Publishing Group, 2021, ⟨10.1038/s41380-021-01301-z⟩
Molecular Psychiatry, 2021, ⟨10.1038/s41380-021-01301-z⟩

Despite the central role of Rho GTPases in neuronal development, their functions in adult hippocampal neurogenesis remain poorly explored. Here, by using a retrovirus-based loss-of-function approach in vivo, we show that the atypical Rho GTPase Rnd2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81ed2f155cdad82eaa476320555ecfb