Výsledky vyhledávání - "Lotterhand J"

Akademický článek

Single Systemic Administration of a Gene Therapy Leading to Disease Treatment in Metachromatic Leukodystrophy Arsa Knock-Out Mice.

Autor: St Martin T; Homology Medicines, Bedford, Massachusetts 01730., Seabrook TA; Homology Medicines, Bedford, Massachusetts 01730., Gall K; Homology Medicines, Bedford, Massachusetts 01730., Newman J; Homology Medicines, Bedford, Massachusetts 01730., Avila N; Homology Medicines, Bedford, Massachusetts 01730., Hayes A; Homology Medicines, Bedford, Massachusetts 01730., Kivaa M; Homology Medicines, Bedford, Massachusetts 01730., Lotterhand J; Homology Medicines, Bedford, Massachusetts 01730., Mercaldi M; Oxford Biomedica Solutions, Bedford, Massachusetts 01730., Patel K; Homology Medicines, Bedford, Massachusetts 01730., Rivas IJ; Homology Medicines, Bedford, Massachusetts 01730., Woodcock S; Homology Medicines, Bedford, Massachusetts 01730., Wright TL; Homology Medicines, Bedford, Massachusetts 01730., Seymour AB; Homology Medicines, Bedford, Massachusetts 01730., Francone OL; Homology Medicines, Bedford, Massachusetts 01730., Gingras J; Homology Medicines, Bedford, Massachusetts 01730 jgingras@homologymedicines.com.

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2023 May 10; Vol. 43 (19), pp. 3567-3581. Date of Electronic Publication: 2023 Mar 28.

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Akademický článek

A novel dual-plasmid platform provides scalable transfection yielding improved productivity and packaging across multiple AAV serotypes and genomes.

Autor: van Lieshout LP; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA., Rubin M; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Costa-Grant K; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA., Ota S; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA., Golebiowski D; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA., Panico T; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA., Wiberg E; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA., Szymczak K; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA., Gilmore R; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA., Stanvick M; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA., Burnham B; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA., Gagnon J; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA., Iwuchukwu I; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA., Yang G; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA., Ghazi I; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA., Meola A; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA., Dickerson R; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA., Thiers T; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA., Mustich L; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA., Hayes A; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Rivas I; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Lotterhand J; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Avila N; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., McGivney J; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA., Yin J; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA., Kelly T; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.

Publikováno v: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2023 May 08; Vol. 29, pp. 426-436. Date of Electronic Publication: 2023 May 08 (Print Publication: 2023).

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Akademický článek

Natural variations in AAVHSC16 significantly reduce liver tropism and maintain broad distribution to periphery and CNS.

Autor: Smith LJ; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Schulman LA; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Smith S; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Van Lieshout L; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Barnes CM; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Behmoiras L; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Scarpitti M; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Kivaa M; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Duong KL; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Benard LO; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Ellsworth JL; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Avila N; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Faulkner D; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Hayes A; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Lotterhand J; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Rivas JI; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Sengooba AV; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Tzianabos A; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Seymour AB; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA., Francone OL; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA.

Publikováno v: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2022 Jun 30; Vol. 26, pp. 224-238. Date of Electronic Publication: 2022 Jun 30 (Print Publication: 2022).

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Akademický článek

Sustained Correction of a Murine Model of Phenylketonuria following a Single Intravenous Administration of AAVHSC15-PAH.

Autor: Ahmed SS; Research and Development, Homology Medicines, 1 Patriots Park, Bedford, MA 01730, USA., Rubin H; Research and Development, Homology Medicines, 1 Patriots Park, Bedford, MA 01730, USA., Wang M; Research and Development, Homology Medicines, 1 Patriots Park, Bedford, MA 01730, USA., Faulkner D; In Vivo Group, Homology Medicines, 1 Patriots Park, Bedford, MA 01730, USA., Sengooba A; In Vivo Group, Homology Medicines, 1 Patriots Park, Bedford, MA 01730, USA., Dollive SN; Research and Development, Homology Medicines, 1 Patriots Park, Bedford, MA 01730, USA., Avila N; In Vivo Group, Homology Medicines, 1 Patriots Park, Bedford, MA 01730, USA., Ellsworth JL; Research and Development, Homology Medicines, 1 Patriots Park, Bedford, MA 01730, USA., Lamppu D; Program Management Group, Homology Medicines, 1 Patriots Park, Bedford, MA 01730, USA., Lobikin M; Process Development, Homology Medicines, 1 Patriots Park, Bedford, MA 01730, USA., Lotterhand J; In Vivo Group, Homology Medicines, 1 Patriots Park, Bedford, MA 01730, USA., Adamson-Small L; Process Development, Homology Medicines, 1 Patriots Park, Bedford, MA 01730, USA., Wright T; Toxicology Group, Homology Medicines, 1 Patriots Park, Bedford, MA 01730, USA., Seymour A; Research and Development, Homology Medicines, 1 Patriots Park, Bedford, MA 01730, USA., Francone OL; Research and Development, Homology Medicines, 1 Patriots Park, Bedford, MA 01730, USA.

Publikováno v: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2020 Mar 13; Vol. 17, pp. 568-580. Date of Electronic Publication: 2020 Mar 13 (Print Publication: 2020).

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Nonclinical comparability studies of recombinant human arylsulfatase A addressing manufacturing process changes.

Autor: Wright T; Shire, Lexington, Massachusetts, United States of America., Li A; Shire, Lexington, Massachusetts, United States of America., Lotterhand J; Shire, Lexington, Massachusetts, United States of America., Graham AR; Shire, Lexington, Massachusetts, United States of America., Huang Y; Shire, Lexington, Massachusetts, United States of America., Avila N; Shire, Lexington, Massachusetts, United States of America., Pan J; Shire, Lexington, Massachusetts, United States of America.

Publikováno v: PloS one [PLoS One] 2018 Apr 19; Vol. 13 (4), pp. e0195186. Date of Electronic Publication: 2018 Apr 19 (Print Publication: 2018).

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Akademický článek

CNS penetration of intrathecal-lumbar idursulfase in the monkey, dog and mouse: implications for neurological outcomes of lysosomal storage disorder.

Autor: Calias P; Shire Human Genetic Therapies, Inc., Lexington, Massachusetts, United States of America. pcalias@shire.com, Papisov M, Pan J, Savioli N, Belov V, Huang Y, Lotterhand J, Alessandrini M, Liu N, Fischman AJ, Powell JL, Heartlein MW

Publikováno v: PloS one [PLoS One] 2012; Vol. 7 (1), pp. e30341. Date of Electronic Publication: 2012 Jan 18.

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