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Akademický článek

NLRX1 Prevents M2 Macrophage Polarization and Excessive Renal Fibrosis in Chronic Obstructive Nephropathy

Autor: Ye Liu, Lotte Kors, Loes M. Butter, Geurt Stokman, Nike Claessen, Coert J. Zuurbier, Stephen E. Girardin, Jaklien C. Leemans, Sandrine Florquin, Alessandra Tammaro

Publikováno v: Cells, Vol 13, Iss 1, p 23 (2023)

Background: Chronic kidney disease often leads to kidney dysfunction due to renal fibrosis, regardless of the initial cause of kidney damage. Macrophages are crucial players in the progression of renal fibrosis as they stimulate inflammation, activat

Externí odkaz: https://doaj.org/article/a19ace71ab7e4aec9b0f3be9ba50d498

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Akademický článek

Parental physical activity is associated with objectively measured physical activity in young children in a sex-specific manner: the GECKO Drenthe cohort

Autor: Silvia I. Brouwer, Leanne K. Küpers, Lotte Kors, Anna Sijtsma, Pieter J. J. Sauer, Carry M. Renders, Eva Corpeleijn

Publikováno v: BMC Public Health, Vol 18, Iss 1, Pp 1-10 (2018)

Abstract Background Physical activity (PA) is important in combating childhood obesity. Parents, and thus parental PA, could influence PA in young children. We examined whether the time spent at different intensities of PA and the type of parental PA

Externí odkaz: https://doaj.org/article/1313bf8a06d6497f83c1b7074f860e86

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Akademický článek

Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling

Autor: Alessia Calcagnì, Lotte kors, Eric Verschuren, Rossella De Cegli, Nicolina Zampelli, Edoardo Nusco, Stefano Confalonieri, Giovanni Bertalot, Salvatore Pece, Carmine Settembre, Gabriel G Malouf, Jaklien C Leemans, Emile de Heer, Marco Salvatore, Dorien JM Peters, Pier Paolo Di Fiore, Andrea Ballabio

Publikováno v: eLife, Vol 5 (2016)

TFE-fusion renal cell carcinomas (TFE-fusion RCCs) are caused by chromosomal translocations that lead to overexpression of the TFEB and TFE3 genes (Kauffman et al., 2014). The mechanisms leading to kidney tumor development remain uncharacterized and

Externí odkaz: https://doaj.org/article/32edca15298541028482d193be8401b5

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The dysregulation of metabolic pathways and induction of the pentose phosphate pathway in renal ischaemia–reperfusion injury

Autor: Alessandra Tammaro, Lotte Kors, Jaklien C. Leemans, Gwendoline J. D. Teske, Sandrine Florquin, Loes M. Butter, James D. Mills, Gerd Schmitz, Elena Rampanelli, Gerhard Liebisch, Joris J. T. H. Roelofs, Angelique M. L. Scantlebery

Publikováno v: The Journal of Pathology
Journal of pathology, 253(4), 404-414. John Wiley and Sons Ltd

Lipid accumulation is associated with various forms of acute renal injury; however, the causative factors and pathways underpinning this lipid accumulation have not been thoroughly investigated. In this study, we performed lipidomic profiling of rena

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3cbc3e57117d8d362b0314db45ff57
https://doi.org/10.1002/path.5605

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Excessive dietary lipid intake provokes an acquired form of lysosomal lipid storage disease in the kidney

Publikováno v: Journal of Pathology

Obesity and dyslipidaemia are features of the metabolic syndrome and risk factors for chronic kidney disease. The cellular mechanisms connecting metabolic syndrome with chronic kidney disease onset and progression remain largely unclear. We show that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1a03b117b030fc71da98f8414acd525
https://doi.org/10.1002/path.5150

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β-Cyclodextrin counteracts obesity in Western diet-fed mice but elicits a nephrotoxic effect

Autor: Loes M. Butter, Marius A. van den Bergh Weerman, Angelique M. L. Scantlebery, Peter Ochodnicky, Nike Claessen, Sandrine Florquin, Joris J. T. H. Roelofs, Jaklien C. Leemans, Chaima El Boumashouli, Gwen J. Teske, Elena Rampanelli, Lotte Kors

Publikováno v: Scientific reports, 9(1):17633. Nature Publishing Group
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports

Obesity has become a worldwide health crisis and is associated with a plethora of comorbidities. The multi-organ effects of obesity have been linked to ectopic lipid accumulation. Thus, there is an urgent need to tackle the obesity crisis by developi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c6e40e745f96d29af645c64693b2b3f
https://pure.amc.nl/en/publications/cyclodextrin-counteracts-obesity-in-western-dietfed-mice-but-elicits-a-nephrotoxic-effect(4beae7f2-a90e-48af-9709-f31ad0379618).html

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Deletion of NLRX1 increases fatty acid metabolism and prevents diet-induced hepatic steatosis and metabolic syndrome

Autor: Loes M. Butter, Lotte Kors, Ntsiki M. Held, Geurt Stokman, Gerd Schmitz, Stephen E. Girardin, Joanne Verheij, Nike Claessen, Jaklien C. Leemans, Riekelt H. Houtkooper, Sandrine Florquin, Gerhard Liebisch, Per W. B. Larsen, Elena Rampanelli, Coert J. Zuurbier

Publikováno v: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1864(5), 1883-1895. Elsevier

NOD-like receptor (NLR)X1 (NLRX1) is an ubiquitously expressed inflammasome-independent NLR that is uniquely localized in mitochondria with as yet unknown effects on metabolic diseases. Here, we report that NLRX1 is essential in regulating cellular m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dff0f9e490f3063bf6420f9b4108fce
https://pure.amc.nl/en/publications/deletion-of-nlrx1-increases-fatty-acid-metabolism-and-prevents-dietinduced-hepatic-steatosis-and-metabolic-syndrome(9bf53a0c-3dfa-4384-b113-ec05311a2f3d).html

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Parental physical activity is associated with objectively measured physical activity in young children in a sex-specific manner: the GECKO Drenthe cohort

Autor: Leanne K. Küpers, Eva Corpeleijn, Anna Sijtsma, Silvia I Brouwer, Carry M. Renders, Pieter J. J. Sauer, Lotte Kors

Publikováno v: BMC Public Health
Brouwer, S I, Küpers, L K, Kors, L, Sijtsma, A, Sauer, P J J, Renders, C M & Corpeleijn, E 2018, ' Parental physical activity is associated with objectively measured physical activity in young children in a sex-specific manner: The GECKO Drenthe cohort ', BMC Public Health, vol. 18, 1033, pp. 1-10 . https://doi.org/10.1186/s12889-018-5883-x
Brouwer, S I, Küpers, L K, Kors, L, Sijtsma, A, Sauer, P J J, Renders, C M & Corpeleijn, E 2018, ' Parental physical activity is associated with objectively measured physical activity in young children in a sex-specific manner : The GECKO Drenthe cohort ', BMC Public Health, vol. 18, 1033 . https://doi.org/10.1186/s12889-018-5883-x
BMC Public Health, 18(1):1033. BMC
BMC Public Health, 18:1033, 1-10. BioMed Central
BMC Public Health, Vol 18, Iss 1, Pp 1-10 (2018)

BACKGROUND: Physical activity (PA) is important in combating childhood obesity. Parents, and thus parental PA, could influence PA in young children. We examined whether the time spent at different intensities of PA and the type of parental PA are ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca33fdaedcc104f824c2ed1e75b25da8
https://pubmed.ncbi.nlm.nih.gov/30126399

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