Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lotte Brückner"'
Autor:
Maja C. Stöber, Rocío Chamorro González, Lotte Brückner, Thomas Conrad, Nadine Wittstruck, Annabell Szymansky, Angelika Eggert, Johannes H. Schulte, Richard P. Koche, Anton G. Henssen, Roland F. Schwarz, Kerstin Haase
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114711- (2024)
Summary: Neuroblastoma exhibits significant inter- and intra-tumor genetic heterogeneity and varying clinical outcomes. Extrachromosomal DNAs (ecDNAs) may drive this heterogeneity by independently segregating during cell division, leading to rapid on
Externí odkaz:
https://doaj.org/article/ab3a75bbde6043eaa8410044fc79d0e5
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Eslicarbazepine acetate (ESL) is a dibenzazepine anticonvulsant approved as adjunctive treatment for partial-onset epileptic seizures. Following first pass hydrolysis of ESL, S-licarbazepine (S-Lic) represents around 95% of circulating active metabol
Externí odkaz:
https://doaj.org/article/11c47f37010046e6ab38e9f0ef2c9ae4
Autor:
Rocío Chamorro González, Thomas Conrad, Maja C. Stöber, Robin Xu, Mădălina Giurgiu, Elias Rodriguez-Fos, Katharina Kasack, Lotte Brückner, Eric van Leen, Konstantin Helmsauer, Heathcliff Dorado Garcia, Maria E. Stefanova, King L. Hung, Yi Bei, Karin Schmelz, Marco Lodrini, Stefan Mundlos, Howard Y. Chang, Hedwig E. Deubzer, Sascha Sauer, Angelika Eggert, Johannes H. Schulte, Roland F. Schwarz, Kerstin Haase, Richard P. Koche, Anton G. Henssen
Extrachromosomal DNAs (ecDNAs) are common in cancer, but many questions about their origin, structural dynamics and impact on intratumor heterogeneity are still unresolved. Here we describe single-cell extrachromosomal circular DNA and transcriptome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc99ed2c6257eafccfbc8313ccf81a41
http://edoc.mdc-berlin.de/23342/2/23342suppl.zip
http://edoc.mdc-berlin.de/23342/2/23342suppl.zip
Autor:
Maja C Stöber, Rocío Chamorro González, Lotte Brückner, Thomas Conrad, Nadine Wittstruck, Annabell Szymansky, Angelika Eggert, Johannes H Schulte, Richard P Koche, Anton G Henssen, Roland F Schwarz, Kerstin Haase
Neuroblastoma is characterised by extensive inter- and intra-tumour genetic heterogeneity and varying clinical outcomes. One possible driver for this heterogeneity are extrachromosomal DNAs (ecDNA), which segregate independently to the daughter cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ae7ba7091ce1e02b5e326aabd499e03
https://doi.org/10.1101/2023.01.21.525014
https://doi.org/10.1101/2023.01.21.525014
Autor:
Yi Bei, Luca Bramé, Marieluise Kirchner, Raphaela Fritsche-Guenther, Sevrine Kunz, Animesh Bhattacharya, Julia Köppke, Jutta Proba, Nadine Wittstruck, Olga A. Sidorova, Rocío Chamorro González, Heathcliff Dorado Garcia, Lotte Brückner, Robin Xu, Mădălina Giurgiu, Elias Rodriguez-Fos, Richard Koche, Clemens Schmitt, Johannes H. Schulte, Angelika Eggert, Kerstin Haase, Jennifer Kirwan, Anja I.H. Hagemann, Philipp Mertins, Jan R. Dörr, Anton G. Henssen
SummaryAlthough DNA amplifications in cancers frequently harbor passenger genes alongside oncogenes, the functional consequence of such co-amplifications and their impact for therapy remains ill-defined. We discovered that passenger co-amplifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23cec1b64f1a5767ede4a61553464d2b
https://doi.org/10.1101/2022.09.08.506647
https://doi.org/10.1101/2022.09.08.506647
Publikováno v:
Nature genetics. 54(2)
Extrachromosomal DNA (ecDNA) amplification has been observed in at least 30 different cancer types and is associated with worse patient outcomes. This has been linked to increased oncogene dosage because both oncogenes and associated enhancers can oc
Autor:
Rocio Chamorro Gonzalez, Thomas Conrad, Robin Xu, Madalina Giurgiu, Maja Cwikla, Katharina Kasack, Lotte Brückner, Eric van Leen, Elias Rodriguez-Fos, Konstantin Helmsauer, Heathcliff Dorado Garcia, Yi Bei, Karin Schmelz, Sascha Sauer, Angelika Eggert, Johannes H. Schulte, Roland F. Schwarz, Kerstin Haase, Richard P. Koche, Anton G. Henssen
Publikováno v:
Cancer Research. 82:1693-1693
Extrachromosomal DNA circularization is a common event in cancer cells and frequently serves as a vehicle for cancer oncogene amplification. Random segregation of oncogene-containing extrachromosomal circular DNA promotes rapid intercellular heteroge