Detection of increased pyruvate dehydrogenase flux in the human heart during adenosine stress test using hyperpolarized [1-13C]pyruvate cardiovascular magnetic resonance imaging

Autor: Steen Hylgaard Joergensen, Esben Soevsoe S. Hansen, Nikolaj Bøgh, Lotte Bonde Bertelsen, Peter Bisgaard Staehr, Rolf F. Schulte, Craig Malloy, Henrik Wiggers, Christoffer Laustsen

Publikováno v: Journal of Cardiovascular Magnetic Resonance, Vol 24, Iss 1, Pp 1-9 (2022)

Abstract Background Hyperpolarized (HP) [1-13C]pyruvate cardiovascular magnetic resonance (CMR) imaging can visualize the uptake and intracellular conversion of [1-13C]pyruvate to either [1-13C]lactate or 13C-bicarbonate depending on the prevailing m

Externí odkaz: https://doaj.org/article/070aed8797de4b5e8f706b063e2e0ee6

Assessment of focal renal ischemia–reperfusion injury in a porcine model using hyperpolarized [ 1‐ 13 C ]pyruvate MRI

Autor: Uffe Kjærgaard, Nikolaj Bøgh, Esben Søvsø Szocska Hansen, Rasmus Stilling Tougaard, Lotte Bonde Bertelsen, Rolf F. Schulte, Christoffer Laustsen

Publikováno v: Kjaergaard, U, Bøgh, N, Hansen, E S S, Tougaard, R S, Bertelsen, L B, Schulte, R F & Laustsen, C 2023, ' Assessment of focal renal ischemia-reperfusion injury in a porcine model using hyperpolarized [1-13 C]pyruvate MRI ', Magnetic Resonance in Medicine, vol. 90, no. 2, pp. 655-663 . https://doi.org/10.1002/mrm.29649

PURPOSE: Ischemic injury in the kidney is a common pathophysiological event associated with both acute kidney injury and chronic kidney disease; however, regional ischemia-reperfusion as seen in thromboembolic renal disease is often undetectable and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a7571d173f8883b66f50e8a86b70c5
https://doi.org/10.1002/mrm.29649

Hyperpolarized [1,4-13C]fumarate imaging detects microvascular complications and hypoxia mediated cell death in diabetic nephropathy

Autor: Lotte Bonde Bertelsen, Haiyun Qi, Per Mose Nielsen, Johan Palmfeldt, Mette Hadberg Løbner, Christoffer Laustsen

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Laustsen, C, Nielsen, P M, Qi, H, Løbner, M H, Palmfeldt, J & Bertelsen, L B 2020, ' Hyperpolarized [1,4-13 C]fumarate imaging detects microvascular complications and hypoxia mediated cell death in diabetic nephropathy ', Scientific Reports, vol. 10, 9650 . https://doi.org/10.1038/s41598-020-66265-6

Today, there is a general lack of prognostic biomarkers for development of renal disease and in particular diabetic nephropathy. Increased glycolytic activity, lactate accumulation and altered mitochondrial oxygen utilization are hallmarks of diabeti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94fb16b87aa573939e61527131910c6f
http://link.springer.com/article/10.1038/s41598-020-66265-6

Concentration-dependent effects of dichloroacetate in type 2 diabetic hearts assessed by hyperpolarized [1

Autor: Esben Søvsø Szocska, Hansen, Lotte Bonde, Bertelsen, Nikolaj, Bøgh, Jack, Miller, Paulus, Wohlfart, Steffen, Ringgaard, Christoffer, Laustsen

Publikováno v: NMR in biomedicineREFERENCES. 35(6)

Personalized medicine or individualized therapy promises a paradigm shift in healthcare. This is particularly true in complex and multifactorial diseases such as diabetes and the multitude of related pathophysiological complications. Diabetic cardiom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a6587decc6d60be6103217c2ed801860
https://pubmed.ncbi.nlm.nih.gov/34961990

Metabolic MRI with hyperpolarized [1-13C]pyruvate separates benign oligemia from infarcting penumbra in porcine stroke

Autor: Daniel B. Vigneron, Rie B. Olin, Jakob Udby Blicher, Jan Henrik Ardenkjær-Larsen, Nikolaj Bøgh, Christoffer Laustsen, Leif Østergaard, Lotte Bonde Bertelsen, Robert Bok, Jeremy W. Gordon, Juan D. Sanchez-Heredia, Esben Søvsø Szocska Hansen, Sabrina Kahina Bech

Publikováno v: Bøgh, N, Olin, R B, Søvsø Szocska Hansen, E, Gordon, J W, Bech, S K, Bertelsen, L B, Sánchez-Heredia, J D, Blicher, J, Østergaard, L, Ardenkjær-Larsen, J H, Bok, R, Vigneron, D & Laustsen, C 2021, ' Metabolic MRI with hyperpolarized [1-13 C]pyruvate separates benign oligemia from infarcting penumbra in porcine stroke ', Journal of Cerebral Blood Flow and Metabolism, vol. 41, no. 11, pp. 2916-2927 . https://doi.org/10.1177/0271678X211018317
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, vol 41, iss 11
Bøgh, N, Olin, R B, Hansen, E S S, Gordon, J W, Bech, S K, Bertelsen, L B, Sánchez-Heredia, J D, Blicher, J U, Østergaard, L, Ardenkjær-Larsen, J H, Bok, R A, Vigneron, D B & Laustsen, C 2021, ' Metabolic MRI with hyperpolarized [1-13C]pyruvate separates benign oligemia from infarcting penumbra in porcine stroke ', Journal of Cerebral Blood Flow and Metabolism, vol. 41, no. 11 . https://doi.org/10.1177/0271678X211018317

Acute ischemic stroke patients benefit from reperfusion in a short time-window after debut. Later treatment may be indicated if viable brain tissue is demonstrated and this outweighs the inherent risks of late reperfusion. Magnetic resonance imaging

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b1003f31dbbf6ab964772b9d4bd1fa
https://pure.au.dk/portal/da/publications/metabolic-mri-with-hyperpolarized-113cpyruvate-separates-benign-oligemia-from-infarcting-penumbra-in-porcine-stroke(0a046797-a133-45b0-959a-93d5d1d7bf1a).html