Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lotta Pohjolainen"'
Autor:
Lotta Pohjolainen, Sini M. Kinnunen, Samuli Auno, Alexandros Kiriazis, Saana Pohjavaara, Julia Kari-Koskinen, Matej Zore, Mikael Jumppanen, Jari Yli-Kauhaluoma, Virpi Talman, Heikki Ruskoaho, Mika J. Välimäki
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background The prevalence of heart failure is constantly increasing, and the prognosis of patients remains poor. New treatment strategies to preserve cardiac function and limit cardiac hypertrophy are therefore urgently needed. Human induced
Externí odkaz:
https://doaj.org/article/e9849cfeb7e34860b937a7a7a18376a5
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundAfter birth, mammalian cardiomyocytes substantially lose proliferative capacity with a concomitant switch from glycolytic to oxidative mitochondrial energy metabolism. Micro-RNAs (miRNAs) regulate gene expression and thus control various ce
Externí odkaz:
https://doaj.org/article/520f1e19c9654d1d87cde56cc0f41872
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 2, Iss , Pp 100020- (2022)
Left ventricular hypertrophy, characterized by hypertrophy of individual cardiomyocytes, is an adaptive response to an increased cardiac workload that eventually leads to heart failure. Previous studies using neonatal rat ventricular myocytes (NRVMs)
Externí odkaz:
https://doaj.org/article/fc2a6429601c4ef69f9f2a67e6504b33
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Background: Hypertrophy of cardiomyocytes (CMs) is initially a compensatory mechanism to cardiac overload, but when prolonged, it leads to maladaptive myocardial remodeling, impairing cardiac function and causing heart failure. A key signaling molecu
Externí odkaz:
https://doaj.org/article/3d32b0334d36473a86f18126267d3d4d
Autor:
Anni Suominen, Guillem Saldo Rubio, Saku Ruohonen, Zoltán Szabó, Lotta Pohjolainen, Bishwa Ghimire, Suvi T. Ruohonen, Karla Saukkonen, Jani Ijas, Sini Skarp, Leena Kaikkonen, Minying Cai, Sharon L. Wardlaw, Heikki Ruskoaho, Virpi Talman, Eriika Savontaus, Risto Kerkelä, Petteri Rinne
Backgroundα-Melanocyte-stimulating hormone (α-MSH) regulates diverse physiological functions by activating melanocortin receptors (MC-R). α-MSH is predominantly expressed in the pituitary gland, but it is also found in several peripheral tissues s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30016c0bf2a37facb0826939534ff5cf
https://doi.org/10.1101/2023.04.06.535956
https://doi.org/10.1101/2023.04.06.535956
Autor:
Jouni Hirvonen, Hélder A. Santos, João F. Pinto, Cláudia Carvalho, Virpi Talman, S. Tuuli Karhu, Vimalkumar Balasubramanian, Mohammad-Ali Shahbazi, Heikki Ruskoaho, Lotta Pohjolainen, Mónica P. A. Ferreira, Giulia Torrieri
Publikováno v:
Advanced Functional Materials, 32(5):2109032. WILEY-V C H VERLAG GMBH
Myocardial infarction results in a massive loss of cardiomyocytes (CMs). Unfortunately, current therapies are unsuccessful in replacing lost CMs, and thus, there is an urgent need for innovative approaches. Here, a nanosystem based on spermine-acetal
Left ventricular hypertrophy, characterized by hypertrophy of individual cardiomyocytes, is an adaptive response to an increased cardiac workload that eventually leads to heart failure. Previous studies using neonatal rat ventricular myocytes (NRVMs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7380a5e8a8f93e12638b723f2c98ac7
https://doi.org/10.1101/2021.12.13.472451
https://doi.org/10.1101/2021.12.13.472451
Autor:
Nikolaj Gadegaard, Francis L. Burton, Godfrey L. Smith, Hao Gao, Radostin D. Simitev, Virpi Talman, Peter Mortensen, Lotta Pohjolainen, Heikki Ruskoaho, Eline Huethorst
Publikováno v:
The Journal of physiology. 600(3)
Key points Spatiotemporal contractility analysis of human induced pluripotent stem cell derived cardiomyocyte (hiPSC-CM) monolayers seeded on conventional, rigid surfaces (glass or plastic) revealed the presence of multiphasic contraction patterns ac
Autor:
Qasim A, Majid, Barbara, Orsolits, Lotta, Pohjolainen, Zsófia, Kovács, Gábor, Földes, Virpi, Talman
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2454
Cardiovascular diseases are one of the leading causes of mortality in the western world. Myocardial infarction is among the most prevalent and results in significant cell loss within the myocardium. Similarly, numerous drugs have been identified as h
Autor:
Virpi Talman, Zsófia Kovács, Lotta Pohjolainen, Barbara Orsolits, Gabor Foldes, Qasim A. Majid
Publikováno v:
Methods in Molecular Biology ISBN: 9781071621189
Cardiovascular diseases are one of the leading causes of mortality in the western world. Myocardial infarction is among the most prevalent and results in significant cell loss within the myocardium. Similarly, numerous drugs have been identified as h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e421e634c9caf8cc5ecb3b1fbc9e8b
https://doi.org/10.1007/7651_2021_369
https://doi.org/10.1007/7651_2021_369