Výsledky vyhledávání - "Lothar W. Habel"

Chemical Synthesis of (S)-4,5-Dihydroxy-2,3-pentanedione, a Bacterial Signal Molecule Precursor, and Validation of Its Activity in Salmonella typhimurium

Autor: Sigrid C. J. De Keersmaecker, Ruth Daniels, Lothar W. Habel, Nadja van Boxel, Kristine Metzger, Jos Vanderleyden, Dirk De Vos, Kathleen Marchal, Csaba Varszegi

Publikováno v: Journal of Biological Chemistry. 280:19563-19568

We describe an original, short, and convenient chemical synthesis of enantiopure (S)-4,5-dihydroxy-2,3-pentanedione (DPD), starting from commercial methyl (S)-(-)-2,2-dimethyl-1,3-dioxolane-4-carboxylate. DPD is the precursor of autoinducer (AI)-2, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8c1a8e6075eeddaa7bcd9fc09a7acf
https://doi.org/10.1074/jbc.m412660200

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Di-ddU-α-Hydroxyphosphonate and α-Hydroxy- α- METHYLPHOSPHONATES as Potential Prodrugs of Antiviral Nucleoside Analogues

Autor: Chris Meier, Lothar W. Habel

Publikováno v: Nucleosides and Nucleotides. 16:1311-1314

The synthesis of a potential new prodrug system for the antiviral nucleoside ddU 1 based on α-hydroxybenzylphosphonates 2 and 3 is described. In principle, 2, 3 are able to hydrolyze via different mechanisms yielding ddU H-phosphonate 4 or ddU monop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::671fa1d32203cbd7a8284f5b82dfe9db
https://doi.org/10.1080/07328319708006178

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Synthesis of vinyl 1,2-diketones

Autor: Pierre Jacobs, Sigrid C. J. De Keersmaecker, Joos Wahlen, Dirk De Vos, Lothar W. Habel

Publikováno v: Tetrahedron Letters. 45:4057-4059

A new route is outlined for preparation of vinyl 1,2-diketones via a three-step sequence. First, allylic alcohols are photooxidized by 1O2 to hydroperoxides, which are reduced to vinyl 1,2-diols. These vinyl 1,2-diols are oxidized to vinyl 1,2-diketo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e41ea971a3400f263afb044ebe079b36
https://doi.org/10.1016/j.tetlet.2004.03.157

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Lipophilic α-hydroxybenzylphosphonates as prodrugs of 3′-azido-2′,3′-dideoxythymidine (AZT)

Autor: Eric De Clercq, Chris Meier, Jan Balzarini, Lothar W. Habel

Publikováno v: Liebigs Annalen. 1995:2195-2202

The α-hydroxybenzylphosphonates 1a–1j of the antiviral drug 3′-azido-2′,3′-dideoxythymidine 5 (AZT) as potential lipophilic prodrugs were readily accessible in 49% to 87% yield via a four-step synthetic pathway introducing the modifications

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bff0dab725221b6a9b5fecdd5fbd60d1
https://doi.org/10.1002/jlac.1995199512305

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5′,5′-di-O-nucleosyl-O′-benzylphosphotriesters as potential prodrugs of 3′-azido-2′,3′-dideoxythymidine-5′-monophosphate

Autor: Jan Balzarini, Eric De Clercq, Lothar W. Habel, Chris Meier

Publikováno v: Liebigs Annalen. 1995:2203-2208

The synthesis of 5′,5′-O-di-(3′-azido-2′,3′-dideoxythymidinyl)-O′-benzylphosphotriesters 1 as potential prodrugs of nucleoside monophosphates is described. The concept is applied to the antiretroviral nucleoside analog 3′-azido-2′,3�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::127736477cefa260949fe4f76addfed2
https://doi.org/10.1002/jlac.1995199512306

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Homo Dinucleoside-α-hydroxyphosphonate Diesters as Prodrugs of the Antiviral Nucleoside Analogues 2',3'-Dideoxythymidine and 3'-Azido-2',3'-dideoxythymidine

Autor: Chris Meier, Wolfgang H.G. Laux, Jan Balzarini, Erik De Clercq, Lothar W. Habel

Publikováno v: Nucleosides, Nucleotides and Nucleic Acids. 14:759-762

The synthesis of a new prodrug system for antiviral nucleosides AZT (1) and ddT (2) based on α-hydroxybenzylphosphonates 3 is described. 3 hydrolyze via different mechanisms yielding the H-phosphonate monoesters 4 or nucleoside monophosphates 5, res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0a70f4ac63df4fa1c8ee88dd5e33362
https://doi.org/10.1080/15257779508012466

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ChemInform Abstract: 5′,5′-Di-O-nucleosyl-O′-benzylphosphotriesters as Potential Prodrugs of 3′-Azido-2′,3′-dideoxythymidine-5′-monophosphate

Autor: Lothar W. Habel, J. Balzarini, E. De Clercq, Chris Meier

Publikováno v: ChemInform. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be38d6a696b49b21c05f2d072fb1cf7a
https://doi.org/10.1002/chin.199614254

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ChemInform Abstract: Lipophilic α-Hydroxybenzylphosphonates as Prodrugs of 3′-Azido-2′ ,3′-dideoxythymidine (AZT)

Autor: Lothar W. Habel, E. De Clercq, J. Balzarini, Chris Meier

Publikováno v: ChemInform. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::255b2737bec5a22730afb7e5981b3fb7
https://doi.org/10.1002/chin.199614253

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Synthesis of N-acyl homoserine lactone analogues reveals strong activators of SdiA, the Salmonella enterica serovar Typhimurium LuxR homologue

Autor: Lothar W. Habel, Joost Janssens, Dirk De Vos, Ruth Daniels, Tine Verhoeven, Kristine Metzger, Sigrid C. J. De Keersmaecker, Jos Vanderleyden, Dave Ptacek

Publikováno v: Applied and environmental microbiology. 73(2)

N -Acyl homoserine lactones (AHLs) are molecules that are synthesized and detected by many gram-negative bacteria to monitor the population density, a phenomenon known as quorum sensing. Salmonella enterica serovar Typhimurium is an exceptional speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4912e7f2307eeb51b578dd9903cb46c2
https://pubmed.ncbi.nlm.nih.gov/17085703

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