Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Lothar Schermelleh"'
Autor:
Martin Houlard, Erin E Cutts, Muhammad S Shamim, Jonathan Godwin, David Weisz, Aviva Presser Aiden, Erez Lieberman Aiden, Lothar Schermelleh, Alessandro Vannini, Kim Nasmyth
Publikováno v:
eLife, Vol 10 (2021)
Dramatic change in chromosomal DNA morphology between interphase and mitosis is a defining features of the eukaryotic cell cycle. Two types of enzymes, namely cohesin and condensin confer the topology of chromosomal DNA by extruding DNA loops. While
Externí odkaz:
https://doaj.org/article/14f97410609d4ed4b8767bc15d72df28
Autor:
David A. Brown, Vincenzo Di Cerbo, Angelika Feldmann, Jaewoo Ahn, Shinsuke Ito, Neil P. Blackledge, Manabu Nakayama, Michael McClellan, Emilia Dimitrova, Anne H. Turberfield, Hannah K. Long, Hamish W. King, Skirmantas Kriaucionis, Lothar Schermelleh, Tatiana G. Kutateladze, Haruhiko Koseki, Robert J. Klose
Publikováno v:
Cell Reports, Vol 20, Iss 10, Pp 2313-2327 (2017)
Chromatin modifications and the promoter-associated epigenome are important for the regulation of gene expression. However, the mechanisms by which chromatin-modifying complexes are targeted to the appropriate gene promoters in vertebrates and how th
Externí odkaz:
https://doaj.org/article/9b58edca6b994f178ed582935538118f
Autor:
Benoit Moindrot, Andrea Cerase, Heather Coker, Osamu Masui, Anne Grijzenhout, Greta Pintacuda, Lothar Schermelleh, Tatyana B. Nesterova, Neil Brockdorff
Publikováno v:
Cell Reports, Vol 12, Iss 4, Pp 562-572 (2015)
X-chromosome inactivation is the process that evolved in mammals to equalize levels of X-linked gene expression in XX females relative to XY males. Silencing of a single X chromosome in female cells is mediated by the non-coding RNA Xist. Although pr
Externí odkaz:
https://doaj.org/article/1128f7ecf32f4264b63b383ff7c04811
Autor:
Sarah Cooper, Martin Dienstbier, Raihann Hassan, Lothar Schermelleh, Jafar Sharif, Neil P. Blackledge, Valeria De Marco, Sarah Elderkin, Haruhiko Koseki, Robert Klose, Andreas Heger, Neil Brockdorff
Publikováno v:
Cell Reports, Vol 7, Iss 5, Pp 1456-1470 (2014)
The mechanisms by which the major Polycomb group (PcG) complexes PRC1 and PRC2 are recruited to target sites in vertebrate cells are not well understood. Building on recent studies that determined a reciprocal relationship between DNA methylation and
Externí odkaz:
https://doaj.org/article/f96cf4b32c5e46e8b5eb04672ddb18dd
Publikováno v:
Biology Open, Vol 1, Iss 10, Pp 965-976 (2012)
Summary Centrioles are essential for the formation of cilia and flagella. They also form the core of the centrosome, which organizes microtubule arrays important for cell shape, polarity, motility and division. Here, we have used super-resolution 3D-
Externí odkaz:
https://doaj.org/article/0126f4e821404f799660c83d9217d91c
Autor:
Paul T Conduit, Jennifer H Richens, Alan Wainman, James Holder, Catarina C Vicente, Metta B Pratt, Carly I Dix, Zsofia A Novak, Ian M Dobbie, Lothar Schermelleh, Jordan W Raff
Publikováno v:
eLife, Vol 3 (2014)
Centrosomes comprise a pair of centrioles surrounded by pericentriolar material (PCM). The PCM expands dramatically as cells enter mitosis, but it is unclear how this occurs. In this study, we show that the centriole protein Asl initiates the recruit
Externí odkaz:
https://doaj.org/article/85cb77be72b349b788f5c3e70ba3faae
Publikováno v:
Nature Protocols. 17:1306-1331
DNA fluorescence in situ hybridization (FISH) has been a central technique in advancing our understanding of how chromatin is organized within the nucleus. With the increasing resolution offered by super-resolution microscopy, the optimal maintenance
Autor:
Danail Stoychev, Richard Parton, Ana Rita Faria, Matthew Wincott, Ian M. Dobbie, Lothar Schermelleh, Ilan Davis, Martin J. J. Booth, Jingyu Wang
Publikováno v:
Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXX.
Autor:
Nicla Porciello, Deborah Cipria, Giulia Masi, Anna-Lisa Lanz, Edoardo Milanetti, Alessandro Grottesi, Duncan Howie, Steve P. Cobbold, Lothar Schermelleh, Hai-Tao He, Marco D’Abramo, Nicolas Destainville, Oreste Acuto, Konstantina Nika
Publikováno v:
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Theoretical work suggests that collective spatiotemporal behaviour of integral membrane proteins (IMPs) can be modulated by annular lipids sheathing their hydrophobic moiety. Here, we present evidence for this prediction in a natural membrane by inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e7ce1fc6756e208d29fd9eed06828c
https://hal.archives-ouvertes.fr/hal-03780160
https://hal.archives-ouvertes.fr/hal-03780160
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2476
Continuing progress in super-resolution microscopy enables the study of sub-chromosomal chromatin organization in single cells with unprecedented detail. Here we describe refined methods for pulse-chase replication labeling of individual chromosome t