Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Lothar Kußmaul"'
Autor:
Bastian Hengerer, Erin Wosnitzka, Yves-Alain Barde, Xinsheng Nan, Michael Schuler, Lothar Kussmaul, Pedro Chacón-Fernández, Jeff Nan
Publikováno v:
eNeuro
Visual Abstract
While BDNF is receiving considerable attention for its role in synaptic plasticity and in nervous system dysfunction, identifying brain circuits involving BDNF-expressing neurons has been challenging. BDNF levels are very low in
While BDNF is receiving considerable attention for its role in synaptic plasticity and in nervous system dysfunction, identifying brain circuits involving BDNF-expressing neurons has been challenging. BDNF levels are very low in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0007d7dfd6ca1655a356b9fadb754e71
https://pubmed.ncbi.nlm.nih.gov/31882533
https://pubmed.ncbi.nlm.nih.gov/31882533
Autor:
Robert Becker, Cornelia Dorner-Ciossek, David Schnell, Wolfgang Weber-Fahr, Alexander Sartorius, Lothar Kußmaul, Stefan Scheuerer, Natalia Gass, Bernhard Schmid
Publikováno v:
Psychopharmacology. 236(12)
The N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine is known to have not only a rapid antidepressant effect but also dissociative side effects. Traxoprodil and lanicemine, also NMDA antagonists, are candidate antidepressant drugs with fewer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcfa34c9d27083287c70e120d24142e1
https://pubmed.ncbi.nlm.nih.gov/31267156
https://pubmed.ncbi.nlm.nih.gov/31267156
Autor:
Mauro Baglioni, Roberta Cecchetti, Carmelinda Ruggiero, Miia Kivipelto, Patrizia Mecocci, Danilo Piobbico, Roberto Monastero, Stefano Brancorsini, Lothar Kussmaul, Francesca Mangialasche
Publikováno v:
Journal of Alzheimer's Disease. 44:649-660
Background: Specific mechanisms behind the role of oxidative/nitrosative stress and mitochondrial dysfunction in Alzheimer's disease (AD) pathogenesis remain elusive. Mitochondrial aconitase (ACO2) is a Krebs cycle enzyme sensitive to free radicalmed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1df068ec02a6ebd14d60eb6214d465
https://doi.org/10.3233/jad-142052
https://doi.org/10.3233/jad-142052
Autor:
Holger Rosenbrock, Bastian Hengerer, Jens Moreth, Cathrin Schnack, Christine A. F. von Arnim, Katja S. Kroker, Daniel Schwanzar, Lothar Kussmaul
Publikováno v:
Biochemistry. 52:1466-1476
In Alzheimer's disease, substantial evidence indicates the causative role of soluble amyloid β (Aβ) aggregates. Although a variety of Aβ assemblies have been described, the debate about their individual relevance is still ongoing. One critical iss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2fb80f943e82035499e09e7bc99827
https://doi.org/10.1021/bi3016444
https://doi.org/10.1021/bi3016444
Publikováno v:
Journal of the Neurological Sciences. 295:46-52
Point mutations in the mitochondrial genome are associated with a variety of metabolic disorders. The myopathy, encephalopathy, lactic acidosis, stroke-like episodes syndrome (MELAS), is most frequently associated with an A to G transition at positio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed9ba3784b6b68cf4478296ac52d1d6
https://doi.org/10.1016/j.jns.2010.05.013
https://doi.org/10.1016/j.jns.2010.05.013
Autor:
Judy Hirst, Lothar Kussmaul
Publikováno v:
Proceedings of the National Academy of Sciences. 103:7607-7612
NADH:ubiquinone oxidoreductase (complex I) is a major source of reactive oxygen species in mitochondria and a significant contributor to cellular oxidative stress. Here, we describe the kinetic and molecular mechanism of superoxide production by comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595211848a7f972137ee46405f550929
https://doi.org/10.1073/pnas.0510977103
https://doi.org/10.1073/pnas.0510977103
Publikováno v:
Glia. 23:139-145
The ability of astroglial cells to detoxify exogenously applied tertiary butyl hydroperoxide (tBHP) was tested using astroglia-rich primary cultures derived from the brains of newborn rats. If 200 microM tBHP was applied, this compound disappeared fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405112a9600c5974834285eadc9d207a
https://doi.org/10.1002/(sici)1098-1136(199806)23:2<139::aid-glia5>3.0.co
https://doi.org/10.1002/(sici)1098-1136(199806)23:2<139::aid-glia5>3.0.co
Publikováno v:
Brain Research Protocols. 2:223-228
Peroxides are often applied to cultured brain cells to investigate functions of these cells under oxidative stress. However, little is known about the ability of brain cells to detoxify peroxides. In order to investigate peroxide clearance of adheren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150563754ed4926c20edb90a50b2d8ab
https://doi.org/10.1016/s1385-299x(97)00047-0
https://doi.org/10.1016/s1385-299x(97)00047-0
Publikováno v:
Brain research bulletin. 96
As nicotinic acetylcholine receptor (nAChR) agonists directly address cholinergic neurotransmission with potential impact on glutamatergic function, they are considered as potential new symptomatic treatment options for Alzheimer's disease compared t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e6eef13c9d6ea9fb257a698ec93bf6
https://pubmed.ncbi.nlm.nih.gov/23639920
https://pubmed.ncbi.nlm.nih.gov/23639920
Autor:
Paolacci, Lucia, Francesca, Mangialasche, Mauro, Baglioni, Roberta, Cecchetti, Miia, Kivipelto, Ruggiero, Carmelinda, Danilo, Piobbico, Lothar, Kussmaul, Roberto, Monastero, Brancorsini, Stefano, Mecocci, Patrizia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3982::4450de3c4183fc2e77b72c753237c692
http://hdl.handle.net/11391/1224328
http://hdl.handle.net/11391/1224328
